Peyote – Mescaline Scientific Papers, AEDMP – 2014-

Peyote – Mescaline Scientific Papers

AEDMP – Asociación para el Estudio y la Divulgación de la Medicina Psicodélica

Research conducted by : Juan Spuch & Genís Oña

Divulgación de la Medicina Psicodélica. Castellarnau, 11 2º 1ª 43004 Tarragona Spain
Tel. 675 55 33 44

1. What is peyote?

2. Scientific papers about peyote – mescaline arranged chronologically (1954-2012)
– H. Denber & S. Merlis (1954). A Note on Some Therapeutic Implications of the Mescaline induced State
– C. Landis & J. Clausen (1954). Certain Effects of Mescaline and Lysergic Acid on Psychological Functions
– J. Cattell (1954). The Influence of Mescaline on Psychodynamic Material
– W. Frederking (1955). Intoxicant Drugs (Mescaline and Lysergic Acid Diethylamide) in Psychotherapy
– L. Berlin et al., (1955). Studies in Human Cerebral Function: The Effects of Mescaline and Lysergic Acid on Cerebral Processes Pertinent to Creative Activity
– F. Rinaldi & H. E. Himwich (1955). The Cerebral Electrographic Changes Induced by LSD and Mescaline are Corrected by Frenquel
– M. Rinkel (1957). Pharmacodynamics of LSD and Mescaline
– P. Hoch (1957). Remarks on LSD and Mescaline
– H. Denber (1958). Studies on Mescaline VIII: Psychodynamic Observations
– G. Koelle (1958). The Pharmacology of Mescaline and D-lysergic Acid Diethylamide (LSD)
– A. Tallaferro et al., (1959). Acción de la Mescalina y la LSD-25 según el Test de Funkenstein
– A. Balestrieri & D. Fontanari (1959). Acquired and Crossed Tolerance to Mescaline, LSD-25, and BOL-148
– P. Naranjo (1959). Estudio Comparativo de la Harmina, la Dietilamida del Ácido Lisérgico (LSD- 25) y la Mescalina
– C. Smith (1959). Some Reflections on the Possible Therapeutic Effects of the Hallucinogens
– A. Wolbach et al., (1962). Cross Tolerance Between Mescaline and LSD-25 With a Comparison of the Mescaline and LSD Reactions
– L. Hollister & A. Hartman (1962). Mescaline, Lysergic Acid Diethylamide and Psilocybin: Comparison of Clinical Syndromes, Effects on Color Perception and Biochemical Measures
– A. Hartman & L. Hollister (1963). Effect of Mescaline, Lysergic Acid Diethylamide and Psilocybin on Color Perception
– S. Unger (1964). Mescaline, LSD, Psilocybin and Personality Change
– F. Hebbard & R. Fischer (1966). Effect of Psilocybin, LSD, and Mescaline on Small Involuntary Eye Movements
– S. Malitz (1966). The Role of Mescaline and D-lysergic Acid in Psychiatric Treatment
– J. MacLean et al., (1967). LSD 25 and Mescaline as Therapeutic Adjuvants
– H. Denber (1969). Mescaline and Lysergic Acid Diethylamide: Therapeutic Implications of the Drug induced State
– G. Aghajanian et al., (1970). LSD and Mescaline : Comparison of Effects on Single Units in the
Midbrain Raphé
– G. Webb & D. Farquharson (1971). Effects of LSD-25 and Mescaline on the Electroplax of the Electric EEL
– C. Bradshaw et al., (1971). Effect of Mescaline on Single Cortical Neurones
– I. Hirschhorn & J. Winter (1971). Mescaline and Lysergic Acid Diethylamide (LSD) as
Discriminative Stimuli
– H. Haigler & G. Aghajanian (1973). Mescaline and LSD: Direct and Indirect Effects on Serotonincontaining Neurons in Brain
– H. Hardman et al., (1973). Relationship of the Structure of Mescaline and Seven Analogs to Toxicity and Behavior in Five Species of Laboratory Animals
– S. Kang et al., (1973). Theoretical Studies on the Conformations of Psilocin and Mescaline
– B. Colasanti & N. Khazan (1975). Electroencephalographic Studies on the Development of Tolerance and Cross Tolerance to Mescaline in the Rat
– A. Shulgin (1979). Mescaline
– L. Hermle et al., (1992). Mescaline-induced Psychopathological, Neuropsychological, and Neurometabolic Effects in Normal Subjects: Experimental Psychosis as a Tool for Psychiatric Research
– K. Nolte & R. Zumwalt (1999). Fatal Peyote Ingestion Associated With Mallory-weiss Lacerations
– D. Perrine (2001). Visions of the Night. Western Medicine Meets Peyote
– M. Terry (2003). Peyote Population Genetics Study
– B. Lu et al., (2004). A Case of Prolonged Peyote-induced Psychosis Resolved by Sleep
– Anonymous (2004). A Mother and Son Peyote Ritual
– J. Halpern (2004). American Indian Religious Freedom
– H. El-Seedi et al., (2005). Prehistoric Peyote Use: Alkaloid Analysis and Radiocarbon Dating of Archeological Specimens of Lophophora From Texas
– J. Halpern et al., (2005). Psychological and Cognitive Effects of Long-term Peyote Use Among Native Americans
– A. Fickenscher et al., (2006). Illicit Peyote Use Among American Indian Adolescents in Substance Abuse Treatment: A Preliminary Investigation
– P. Kovacic & R. Somanathan (2009). Novel, Unifying Mechanism for Mescaline in the Central Nervous System
– S. Carstairs & L. Cantrell (2010). Peyote and Mescaline Exposures: A 12-year Review of a Statewide Poison Center Database
– E. Kyzar et al., (2012). Effects of Hallucinogenic Agents Mescaline and Phencyclidine on Zebrafish Behavior and Physiology


What is Peyote ?

Peyote (Lophophora Williamsii ) is a cactus found primarily in dry regions of Mexico and State of Texas. This cactus contains psychoactive alkaloids, but mescaline is the most important. For its psychedelic effects, the dried tops of the cactus, also known as “buttons”, have been used for centuries by Native Americans in religious ceremonies and for the treatment of various physical ailments. Mescaline is one of the oldest hallucinogens known by man. His clinical effects are similar to psychedelics like LSD or MDMA, and it has historically been used as a reference standard in hallucinogen research. A full dose of mescaline (200 to 400 mg) has a long duration of action, with peak effects 2 to 4 hours after consumption, declining over the next 8 hours. Many of the studies done with mescaline also included other psychedelics, like LSD or psilocybin; we decided to include these polydrug studies for his relevance anyway.