Étiquette : safety

A Phase 1, Randomised, Placebo-Controlled, Dose Escalation Study to Investigate the Safety, Tolerability and Pharmacokinetics of Cannabidiol in Fed Healthy Volunteers, Daniel Perkins et al., 2020

A Phase 1, Randomised, Placebo-Controlled, Dose Escalation Study to Investigate the Safety, Tolerability and Pharmacokinetics of Cannabidiol in Fed Healthy Volunteers Daniel Perkins · Juliet Butler · Katherine Ong · Tri‑Hung Nguyen · Susan Cox · Barbara Francis · Michelle Mcintosh · Brian Lilley European Journal of Drug Metabolism and Pharmacokinetics, 2020, Doi : 10.1007/s13318-020-00624-6 Abstract Background : There is increasing interest in the use of purified cannabidiol (CBD) as a treatment for a wide range of conditions due to its reported anti-inflammatory, anxiolytic, antiemetic and anticonvulsant properties. Objective : The objective of this study was to assess the [...]

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What does the ecological and epidemiological evidence indicate about the potential for cannabinoids to reduce opioid use and harms ? A comprehensive review, Gabrielle Campbell, 2018

What does the ecological and epidemiological evidence indicate about the potential for cannabinoids to reduce opioid use and harms ? A comprehensive review Gabrielle Campbell, Wayne Hall and Suzanne Nielsen International Review of Psychiatry, 2018, 1-16. Doi : 10.1080/09540261.2018.1509842   ABSTRACT Pre-clinical research supports that cannabinoids reduce opioid dose requirements, but few studies have tested this in humans. This review evaluates ecological and epidemiological studies that have been cited as evidence that medical cannabis use may reduce opioid use and opioidrelated harms. Medline and Embase were searched for relevant articles. Data were extracted on study setting, analyses approach, covariates, and outcomes. Eleven ecological and 14 epidemiological [...]

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Il y a urgence à prescrire du cannabis dans les Ehpad, Jean-Yves Nau et William Lowenstein, Slate.fr, 16 avril 2020

Il y a urgence à prescrire du cannabis dans les Ehpad Jean-Yves Nau et William Lowenstein — 16 avril 2020 à 10h58 http://www.slate.fr/story/189561/confinement-urgence-prescrire-cannabis-personnes-agees-ehpad Surconfiner les personnes âgées conduit à une consommation désastreuse de benzodiazépines et d'antalgiques opiacés. C'est oublier les vertus alternatives du cannabis médical. La maniabilité de l'administration du cannabis thérapeutique, notamment sous forme de tisanes, est fort intéressante. | Kimzy Nanney via Unsplash Combien, avant l'épidémie, se souciaient des Ehpad, de leurs résident·es, de leurs soignant·es? Combien étions-nous à connaître la signification de cet étrange acronyme, Établissement d'hébergement pour personnes âgées dépendantes? La progression fulgurante du SARS-CoV-2, quelques reportages, de douloureux témoignages, [...]

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Confinement et cannabis, cachez cette addiction que le gouvernement ne saurait voir, Jean-Yves Nau, Slate.fr, 2 avril 2020

Confinement et cannabis, cachez cette addiction que le gouvernement ne saurait voir Jean-Yves Nau — 2 avril 2020 à 7h00 http://www.slate.fr/story/189123/addictions-cannabis-confinement-coronavirus-deni-consequences-dependance Tabac, alcool et produits de vapotage n'ont heureusement pas été interdits. Mais il va falloir compter avec les multiples conséquences de la pénurie en cannabis. «Une dépendance grave à une substance licite vaut toujours mieux qu'une dépendance de moindre gravité à une substance interdite», déplore le Dr William Lowenstein, président de SOS Addictions. | realworkhard, ponce_photography et gjbmiller via Pixabay Il croyait très bien faire. Lundi 23 mars, Ziad Khoury, préfet de l'Aisne, prenait un arrêté interdisant toutes les ventes d'alcool à emporter dans l'ensemble du [...]

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Short-term effects of cannabis consumption on cognitive performance in medical cannabis patients, Phillip Olla et al., 2019

Short-term effects of cannabis consumption on cognitive performance in medical cannabis patients Phillip Olla, Nicholas Rykulski, Jessica L. Hurtubise, Stephen Bartol, Rachel Foote, Laura Cutler, Kaitlyn Abeare, Nora McVinnie, Alana G. Sabelli, Maurissa Hastings, and Laszlo A. Erdodi Applied Neuropsychology : Adult, 2019, 1-11. Doi : 10.1080/23279095.2019.1681424   ABSTRACT This observational study examined the acute cognitive effects of cannabis. We hypothesized that cognitive performance would be negatively affected by acute cannabis intoxication. Twenty-two medical cannabis patients from Southwestern Ontario completed the study. The majority (n¼13) were male. Mean age was 36.0 years, and mean level of education was 13.7 years. Participants were administered the same brief neurocognitive battery three times during [...]

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Quality of Life, Mental Health, Personality and Patterns of Use in Self-Medicated Cannabis Users with Chronic Diseases : A 12-Month Longitudinal Study, BOUSO J.C. et al., 2020

Quality of Life, Mental Health, Personality and Patterns of Use in Self-Medicated Cannabis Users with Chronic Diseases : A 12-Month Longitudinal Study. BOUSO J.C., JIMENEZ-GARRIDO D., ONA G., WOZNICA D., dos SANTOS R.G., HALLAK J.E.C., PARANHOS B. A., de ALMEIDA MENDES F., YONAMINE M. et al. : Phytotherapy Research, 2020. Doi : 10.1002/ptr.6639 © 2020 John Wiley & Sons, Ltd. Abstract The number of patients using cannabis for therapeutic purposes is growing worldwide. While research regarding the treatment of certain diseases/disorders with cannabis and cannabinoids is also expanding, only a few longitudinal studies have assessed the mid-term impacts of medical cannabis use on psychological variables and quality [...]

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LE CBD EST-IL PSYCHOACTIF ? François-Olivier GAGNON-HÉBERT, 2019

LE CBD EST-IL PSYCHOACTIF ? François-Olivier GAGNON-HÉBERT – Chercheur Postdoctoral/ Université de Moncton, Canada La Lettre du RESPADD, 2019, 36, 4-5 https://www.respadd.org/lettre-n36-octobre-2019/   Il semble y avoir une véritable résurgence du cannabis dans les débats publics à l’échelle internationale depuis quelques années. Cette plante cultivée depuis les premiers balbutiements des sociétés humaines néolithiques grégaires (Warf 2014) ne laisse personne indifférent. Bien que les apologistes et les détracteurs de l’usage de la plante ne s’entendent généralement sur aucun point, tous s’entendent sur la réalité suivante : il s’agit d’une question fort complexe et épineuse. Au-delà des débats moraux et sociétaux, il n’en demeure pas moins que le cannabis [...]

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Pharmacokinetics and subjective effects of a novel oral LSD formulation in healthy subjects, Friederike Holze et al., 2019

Pharmacokinetics and subjective effects of a novel oral LSD formulation in healthy subjects Friederike Holze, Urs Duthaler, Patrick Vizeli, Felix Müller, Stefan Borgwardt, Matthias E. Liechti British Journal of Clinical Pharmacology, March 2019 Doi : 10.1111/bcp.13918   Aims : The aim of the present study was to characterize the pharmacokinetics and exposure–subjective response relationship of a novel oral solution of lysergic acid diethylamide (LSD) that was developed for clinical use in research and patients. Method : LSD (100 μg) was administered in 27 healthy subjects using a placebocontrolled, double‐blind, cross‐over design. Plasma levels of LSD, nor‐LSD, and 2‐ oxo‐3‐hydroxy‐LSD (O‐H‐LSD) and subjective drug effects were assessed [...]

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Medicinal Plants of the Russian Pharmacopoeia ; their history and applications, Alexander N. Shikov et al., 2014

Medicinal Plants of the Russian Pharmacopoeia; their history and applications Alexander N. Shikov, Olga N. Pozharitskaya, Valery G. Makarov, Hildebert Wagner, Rob Verpoorte, Michael Heinrich Journal of Ethnopharmacology, 2014, 154, 481–536 Doi : 10.1016/j.jep.2014.04.007   Ethnopharmacological relevance : Due to the location of Russia between West and East, Russian phytotherapy has accumulated and adopted approaches that originated in European and Asian traditional medicine. Phytotherapy is an official and separate branch of medicine in Russia; thus, herbal medicinal preparations are considered official medicaments.The aim of the present review is to summarize and critically appraise data concerning plants used in Russian medicine.This review describes the history of herbal [...]

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