Catégorie : Cannabis et santé mentale

Cannabinoid CB2 Receptor Gene and Environmental Interaction in the Development of Psychiatric Disorders, Hiroki Ishiguro et al., 2018

Cannabinoid CB2 Receptor Gene and Environmental Interaction in the Development of Psychiatric Disorders Hiroki Ishiguro, Yasue Horiuch, Koichi Tabata, Qing-Rong Liu, Tadao Arinami and Emmanuel S. Onaivi Molecules, 2018, 23, 1836; doi : 10.3390/molecules23081836 Abstract : CB2 cannabinoid receptor (CB2R) gene is associated with depression. We investigated the gene-environment interaction between CB2R function and diverse stressors. First, anxiety-like behavior during chronic-mild-stress (CMS) was evaluated in C57BL/6JJmsSlc mice following treatment with CB2R agonist JWH015 or inverse-agonist AM630. Second, locomotor activity and anxiety-like behavior were measured following exposure to an immune poly I:C stressor. Gene expressions of HPA axis related molecules, Fkbp5, Nr3c1 and Crf and [...]

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Chronic Adolescent D9-Tetrahydrocannabinol Treatment of Male Mice Leads to Long-Term Cognitive and Behavioral Dysfunction, Which Are Prevented by Concurrent Cannabidiol Treatment, Michelle Murphy et al., 2017

Chronic Adolescent D9-Tetrahydrocannabinol Treatment of Male Mice Leads to Long-Term Cognitive and Behavioral Dysfunction, Which Are Prevented by Concurrent Cannabidiol Treatment Michelle Murphy,Sierra Mills, Joanna Winstone, Emma Leishman, Jim Wager-Miller, Heather Bradshaw, and Ken Mackie Cannabis and Cannabinoid Research, Volume 2.1, 2017 DOI: 10.1089/can.2017.0034 Abstract Introduction : The high prevalence of adolescent cannabis use, the association between this use and later psychiatric disease, and increased access to high-potency cannabis highlight the need for a better understanding of the long-term effects of adolescent cannabis use on cognitive and behavioral outcomes. Furthermore, increasing Δ9-tetrahydrocannabinol (THC) in high-potency cannabis is accompanied by a decrease in cannabidiol (CBD), thus [...]

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Chapter : The endocannabinoid system in Fragile X Syndrome, Henry G. S. Martin et al., 2017

Chapter : The endocannabinoid system in Fragile X Syndrome Henry G. S. Martin, Daniela Neuhofer and Olivier J.J. Manzoni Fragile X Syndrome : From Genetics to Targeted Treatment, 2017, Pages 241-259 DOI: 10.1016/B978-0-12-804461-2.00012-3 Addresses: INSERM U901, INMED and UMR S901, Aix-Marseille University Marseille 13009, France. Abstract : Endocannabinoid signaling is a finely tuned system of molecules and lipid messengers that modulate neurotransmission in a rapid and sustained manner at many central synapses. The endocannabinoid system is important for many brain activities, but is also implicated in several neuropsychiatric disorders. In this chapter we discuss emerging evidence of dysfunction in endocannabinoid signaling in Fragile X Syndrome from the Fmr1 knockout mouse model. [...]

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Cannabinoid Actions on Neural Stem Cells : Implications for Pathophysiology, Rui S. Rodrigues et al., 2019

Cannabinoid Actions on Neural Stem Cells : Implications for Pathophysiology Rui S. Rodrigues, Diogo M. Lourenço, Sara L. Paulo, Joana M. Mateus, Miguel F. Ferreira, Francisco M. Mouro, João B. Moreira, Filipa F. Ribeiro, Ana M. Sebastião and Sara Xapelli Molecules, 2019, 24, 1350, 59 pp. Abstract : With the increase of life expectancy, neurodegenerative disorders are becoming not only a health but also a social burden worldwide. However, due to the multitude of pathophysiological disease states, current treatments fail to meet the desired outcomes. Therefore, there is a need for new therapeutic strategies focusing on more integrated, personalized and effective approaches. The prospect [...]

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Modulation of Astrocyte Activity by Cannabidiol, a Nonpsychoactive Cannabinoid, Ewa Kozela et al., 2017

Modulation of Astrocyte Activity by Cannabidiol, a Nonpsychoactive Cannabinoid. Ewa Kozela, Ana Juknat, and Zvi Vogel International Journal of Molecular Sciences, 2017, 18, 1669, 20 pp. doi:10.3390/ijms18081669 PMID : 28788104   PMCID : PMC5578059 Abstract The astrocytes have gained in recent decades an enormous interest as a potential target for neurotherapies, due to their essential and pleiotropic roles in brain physiology and pathology. Their precise regulation is still far from understood, although several candidate molecules/systems arise as promising targets for astrocyte-mediated neuroregulation and/or neuroprotection. The cannabinoid system and its ligands have been shown to interact and affect activities of astrocytes. Cannabidiol (CBD) is the main [...]

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Cannabis-associated symptom profiles in patients with first episode psychosis and population controls, Diego Quattrone et al., 2019,

Cannabis-associated symptom profiles in patients with first episode psychosis and population controls Diego Quattrone, Laura Ferraro, Giada Tripoli, Erika LaCascia, Harriet Quigley, EU-GEI group, Charlotte Gayer-Anderson, Peter B. Jones, James B. Kirkbride, Daniele La Barbera, Ilaria Tarricone, Michael T. Lynskey, Tom P. Freeman, Pak C. Sham, Alaistar Cardno, Evangelos Vassos, Jim van Os, Craig Morgan, Ulrich Reininghaus, Cathryn M. Lewis, Robin M. Murray, and Marta Di Forti mars 2019 DOI : 10.1101/577932 Abstract : Objective : The evidence is mixed on whether cannabis use is associated with a particular symptomatology in first episode psychosis (FEP) patients. The authors set out to investigate a) patterns of [...]

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Neuroimaging Studies of Acute Effects of THC and CBD in Humans and Animals : a Systematic Review, Albert Batalla et al., 2014

Neuroimaging Studies of Acute Effects of THC and CBD in Humans and Animals : a Systematic Review A. Batalla, J.A. Crippa, G.F. Busatto, F.S. Guimarães, A.W. Zuardi, O. Valverde, Z. Atakan, P.K. McGuire, S. Bhattacharyya and R. Martín-Santos Current Pharmaceutical Design, 2014,  20, 2168-2185 DOI : 10.2174/13816128113199990432 Available from: https://www.researchgate.net/publication/247154314_Neuroimaging_Studies_of_Acute_Effects_of_THC_and_CBD_in_Humans_and_Animals_a_Systematic_Review [accessed May 19, 2019]. Abstract : Background : In recent years, growing concerns about the effects of cannabis use on mental health have renewed interest in cannabis research. In particular, there has been a marked increase in the number of neuroimaging studies of the effects of cannabinoids. We conducted a systematic review to assess the [...]

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Streets of the ‘spice zombies’: Dependence and poverty stigma in times of austerity, Crime Media Culture, 2019

Streets of the ‘spice zombies’: Dependence and poverty stigma in times of austerity Liviu Alexandrescu School of History, Philosophy and Culture, Oxford Brookes University Crime Media Culture, 2019 Abstract Following the 2016 general ban on new psychoactive substances, synthetic cannabinoids (‘spice’-type drugs) have moved into unregulated street markets and have become popular among homeless populations in the United Kingdom. Images of so-called ‘spice zombies’, rough sleepers in public spaces experiencing severe substance-induced fits, have been used by local and national media to suggest the growing scale of the problem. This article proposes that such depictions should be read through a cultural analysis rooted in the [...]

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Association of Cannabis Use in Adolescence and Risk of Depression, Anxiety, and Suicidality in Young Adulthood – A Systematic Review and Meta-analysis, Gabriella Gobbi et al., 2019

Association of Cannabis Use in Adolescence and Risk of Depression, Anxiety, and Suicidality in Young Adulthood - A Systematic Review and Meta-analysis Gabriella Gobbi, Tobias Atkin, Tomasz Zytynski, Shouao Wang, Sorayya Askari, Jill Boruff,  Mark Ware, Naomi Marmorstein, Andrea Cipriani, Nandini Dendukuri, Nancy Mayo JAMA Psychiatry, 2019, 76, 4, 426-434. doi:10.1001/jamapsychiatry.2018.4500 Published online February 13, 2019. Corrected on March 13, 2019. https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2723657?guestAccessKey=c2ffca43-46c1-4563-8949-c1625bfbdefa&utm_source=silverchair&utm_medium=email&utm_campaign=article_alert-jamanetwork&utm_content=weekly_highlights&utm_term=051919   IMPORTANCE : Cannabis is the most commonly used drug of abuse by adolescents in the world. While the impact of adolescent cannabis use on the development of psychosis has been investigated in depth, little is known about the impact of cannabis use on mood [...]

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Modulation of acute effects of delta-9-tetrahydrocannabinol on psychotomimetic effects, cognition and brain function by previous cannabis exposure, Marco Colizzi et al., 2018

Modulation of acute effects of delta-9-tetrahydrocannabinol on psychotomimetic effects, cognition and brain function by previous cannabis exposure Marco Colizzi, Philip McGuire, Vincent Giampietro, Steve Williams, Mick Brammer, Sagnik Bhattacharyya, European Neuropsychopharmacology, 2018, 28, 850-862. https://doi.org/10.1016/j.euroneuro.2018.04.003 0924-977X/ ©2018 ElsevierB.V. and ECNP. All rights reserved. KEYWORDS : Cannabis use; Delta-9-tetrahydrocannabinol; Functional Magnetic Resonance Imaging; Cognitive functioning; Tolerance; Psychosis Abstract Cannabis use has been associated with psychosis and cognitive dysfunction. Some evidence suggests that the acute behavioral and neurocognitive effects of the main activei ngredient in cannabis, (-)-trans-Δ9 tetrahydrocannabinol (Δ9-THC), might be modulated by previous cannabis exposure. However, this has not been investigated either using a control group of non-users, [...]

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