Étiquette : recherche

CBD Isolates Vs. Full-Spectrum CBD, Martin A. LEE, projectCBD.org, 2015

CBD Isolates Vs. Full-Spectrum CBD Martin A. Lee On February 22, 2015 https://www.projectcbd.org/science/cbd-isolates-vs-full-spectrum-cbd A groundbreaking study has documented the superior therapeutic properties of whole plant CBD-rich cannabis extract as compared to single-molecule CBD.   A groundbreaking study from Israel has documented the superior therapeutic properties of whole plant CBD-rich cannabis extract as compared to single-molecule cannabidiol (CBD). Published in the journal Pharmacology & Pharmacy (Feb. 2015), the article directly challenges one of the sacred cows of Big Pharma and the medical-industrial complex—the notion that “crude” botanical preparations are inherently low grade and less effective than pure, single-molecule compounds. Entitled “Overcoming the Bell-Shaped Dose-Response of Cannabidiol by Using Cannabis [...]

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The effects of microdose LSD on time perception: a randomised, double-blind, placebo-controlled trial, Steliana Yanakieva et al., 2018

The effects of microdose LSD on time perception: a randomised, double-blind, placebo-controlled trial Steliana Yanakieva, Naya Polychroni, Neiloufar Family, Luke T. J. Williams, David P. Luke & Devin B. Terhune Psychopharmacology, 2018, 1-12. https://doi.org/10.1007/s00213-018-5119-x   Abstract Rationale : Previous research demonstrating that lysergic acid diethylamide (LSD) produces alterations in time perception has implications for its impact on conscious states and a range of psychological functions that necessitate precise interval timing. However, interpretation of this research is hindered by methodological limitations and an inability to dissociate direct neurochemical effects on interval timing from indirect effects attributable to altered states of consciousness. Methods : We conducted a randomised, double-blind, [...]

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Psychedelics : Where we are now, why we got here, what we must do, Sean J. Belouin & Jack E. Henningfield, 2018

Psychedelics : Where we are now, why we got here, what we must do Sean J. Belouin, Jack E. Henningfield Neuropharmacology, 2018, 142, 7e19 https://doi.org/10.1016/j.neuropharm.2018.02.018 a b s t r a c t The purpose of this commentary is to provide an introduction to this special issue of Neuropharmacology with a historical perspective of psychedelic drug research, their use in psychiatric disorders, research restricting regulatory controls, and their recent emergence as potential breakthrough therapies for several brain-related disorders. It begins with the discovery of lysergic acid diethylamide (LSD) and its promising development as a treatment for several types of mental illnesses during the 1940s. This was [...]

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Psychiatry & the psychedelic drugs. Past, present & future, James J.H. Rucker et al., 2018

Psychiatry & the psychedelic drugs. Past, present & future James J.H. Rucker, Jonathan Iliff, David J. Nutt Neuropharmacology, 2018, 142, 200e218 https://doi.org/10.1016/j.neuropharm.2017.12.040   a b s t r a c t The classical psychedelic drugs, including psilocybin, lysergic acid diethylamide and mescaline, were used extensively in psychiatry before they were placed in Schedule I of the UN Convention on Drugs in 1967. Experimentation and clinical trials undertaken prior to legal sanction suggest that they are not helpful for those with established psychotic disorders and should be avoided in those liable to develop them. However, those with so-called ‘psychoneurotic’ disorders sometimes benefited considerably from their tendency to [...]

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Tribune pour l’expérimentation des psychédéliques en médecine, contre la dépression, l’anxiété, les addictions et pour les soins palliatifs, Société Psychédélique Française, 2019

Tribune pour l’expérimentation des psychédéliques en médecine, contre la dépression, l’anxiété, les addictions et pour les soins palliatifs. Société Psychédélique Française, novembre 2019   D’après l’Organisation mondiale de la santé, une personne sur quatre dans le monde sera affectée à un moment donné de sa vie par des troubles mentaux ou neurologiques. Or, après des décennies d’oubli, nous assistons en dehors de nos frontières à un regain de la recherche clinique psychothérapeutique sur les psychédéliques et au développement de thérapies novatrices impliquant ces substances. Les psychédéliques sont des composés, issus du monde vivant ou de la chimie, provoquant des effets analogues sur le psychisme [...]

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Chapter 8 : Pilgrimage to the Light ? On the Threshold of a Dream: Sacred Plants, Passionate Dedication to Ideals, and Healing, Richard Yensen, 2015

Chapter 8 : Pilgrimage to the Light ? On the Threshold of a Dream: Sacred Plants, Passionate Dedication to Ideals, and Healing Richard Yensen January 2015 https://www.researchgate.net/publication/282132139   The desire to incorporate ancient healing practices with sacred plants into modern medicine has been a central passion of my career as a clinician and psychedelic researcher for over 40 years. During that time Mexico has offered me friendship, collegiality, adventure, and wonder. At times I have felt when visiting first Nations in Mexico like I was stepping back into ancient times. The wonder and honor of knowing Maria Sabina, Don Ricardo, Niuweme, and other healers and [...]

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Effects of endocannabinoid neurotransmission modulators on brain stimulation reward, Styliani Vlachou et al., 2006

Effects of endocannabinoid neurotransmission modulators on brain stimulation reward Styliani Vlachou, George G. Nomikos & George Panagis Psychopharmacology, 2006, 188, 293–305 Doi : 10.1007/s00213-006-0506-0   Abstract Rationale : The endogenous cannabinoid system is responsive to the neurobiological actions of Δ9-tetrahydrocannabinol (THC) and other cannabinoid ligands. While numerous studies have focused on the behavioral and pharmacological effects of THC and cannabinoid agonists in experimental animals, most recent work focuses on compounds that modulate endocannabinoid neurotransmission. However, the relevant studies concerning the ability of endocannabinoid modulators to modify reward processes in experimental animals remain rather scarce. Objectives : The present study examined the effects of drugs modulating endocannabinoid neurotransmission on [...]

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Research ethics aspects of experimentation with LSD on human subjects : a historical and ethical review, Bodnár Kristóf János & Kakuk Péter, 2018

Research ethics aspects of experimentation with LSD on human subjects : a historical and ethical review Bodnár Kristóf János, Kakuk Péter Medicine, Health Care and Philosophy © Springer Nature B.V. 2018 https://doi.org/10.1007/s11019-018-9871-9 Abstract In this paper our aim is to examine whether research conducted on human participants with LSD-25 (lysergic acid diethylamide) raises unique research ethical questions or demands particular concerns with regard to the design, conduct and follow-up of these studies, and should this be the case, explore and describe those issues. Our analysis is based on reviewing publications up to date which examine the clinical, research and other uses of LSD and those addressing [...]

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Using Cannabis To Help You Sleep: Heightened Frequency of Medical Cannabis Use among Those with PTSD, Marcel O. Bonn-Miller et al., 2014,

Using Cannabis To Help You Sleep: Heightened Frequency of Medical Cannabis Use among Those with PTSD Marcel O. Bonn-Miller, Kimberly A. Babson, and Ryan Vandrey Drug and Alcohol Dependence, 2014, 136, 162–165. doi:10.1016/j.drugalcdep.2013.12.008   Abstract Background : The use of cannabis for medical purposes is proliferating in the U.S., and PTSD is an explicitly approved condition for accessing medical cannabis in 5 states. Prior research suggests that people with PTSD often use cannabis to help cope with their condition, and that doing so results in more frequent and problematic cannabis use patterns. Specific coping motivations, such as sleep improvement, among medical cannabis users, have not been [...]

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