Étiquette : recherche

Ayahuasca in Adolescence : A Neuropsychological Assessment, Evelyn Doering-Silveira, Charles S. Grob et al., 2005

Ayahuasca in Adolescence : A Neuropsychological Assessment Evelyn Doering-Silveira, Enrique Lopez,  Charles S. Grob, Marlene Dobkin de Rios, Luisa K. Alonso, Cristiane Tacla,Itiro Shirakawa,  Paulo H. Bertolucci,  & Dartiu X. Da Silveira Journal of Psychoactive Drugs, 2005, 37, (2), 123-128.   Abstract The purpose of the study was to evaluate neuropsychologically adolescents who use ayahuasca in a religious context. A battery of neuropsychological tests was administered to adolescents who use ayahuasca. These subjects were compared to a matched control group of adolescents who did not use ayahuasca. The controls were matched with regards to sex, age, and education. The neuropsychological battery included tests of speeded [...]

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Histoire. La résine de cannabis : remède miracle ou poison d’Orient ?, Le Courrier International, David A Guba Jr.,2019.

Planche botanique de Cannabis sativa tirée du Nordisk familjebok, une encyclopédie suédoise publiée entre 1876 et 1957. Wikicommons Histoire. La résine de cannabis : remède miracle ou poison d’Orient ? David A Guba Jr.11 octobre 2019   XIXe siècle – France. Dans les années 1830, alors que la pandémie de choléra frappe l’Europe, le milieu médical français se passionne pour la résine de cannabis, parée de toutes les vertus. Nombreux sont ceux qui ont applaudi à l’annonce d’un début de réglementation prenant mieux en compte les enjeux de santé publique sur la consommation de cannabis en France. L’Agence nationale de sécurité du médicament a salué les [...]

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Comparison of the Neurotoxic and Seizure-Inducing Effects of Synthetic and Endogenous Cannabinoids with Δ9-Tetrahydrocannabinol

Comparison of the Neurotoxic and Seizure-Inducing Effects of Synthetic and Endogenous Cannabinoids with Δ9-Tetrahydrocannabinol Chris S. Breivogel, Jacob R. Wells, Amreen Jonas, Artik H. Mistry, Morgan L. Gravley, Rajul M. Patel, Brianna E. Whithorn, and Bonnie M. Brenseke Cannabis and Cannabinoid Research, 2019, Volume X, Number X DOI: 10.1089/can.2019.0003 Abstract Introduction : Synthetic cannabinoids (SCs) are commonly found in preparations used as recreational drugs. Although severe adverse health effects are not generally associated with cannabis use, a rising number of studies document seizures and even death after SC use. In this study, a mouse model is used to investigate the hypothesis that SCs are more [...]

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2-Linoleoylglycerol Is a Partial Agonist of the Human Cannabinoid Type 1 Receptor that Can Suppress 2-Arachidonolyglycerol and Anandamide Activity, Leanne Lu et al., 2019

2-Linoleoylglycerol Is a Partial Agonist of the Human Cannabinoid Type 1 Receptor that Can Suppress 2-Arachidonolyglycerol and Anandamide Activity Leanne Lu, Gareth Williams, and Patrick Doherty Cannabis and Cannabinoid Research, 2019, Volume X, Number X Doi : 10.1089/can.2019.0030 Abstract Introduction : The cannabinoid type 1 (CB1) receptor and cannabinoid type 2 (CB2) receptor are widely expressed in the body and anandamide (AEA) and 2-arachidonoylglycerol (2-AG) are their best characterized endogenous ligands. The diacylglycerol lipases (diacylglycerol lipase alpha and diacyl-glycerol lipase beta) not only synthesize essentially all the 2-AG in the body but also generate other monoacylglycerols, including 2-linoleoylglycerol (2-LG). This lipid has been proposed to modulate endocannabinoid [...]

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Receptor-Enriched Analysis of functional connectivity by targets (REACT) : A novel, multimodal analytical approach informed by PET to study the pharmacodynamic response of the brain under MDMA, Ottavia Dipasquale et al., 2019

Receptor-Enriched Analysis of functional connectivity by targets (REACT) : A novel, multimodal analytical approach informed by PET to study the pharmacodynamic response of the brain under MDMA Ottavia Dipasquale, Pierluigi Selvaggi, Mattia Veronese, Anthony S. Gabay, Federico Turkheimer, Mitul A. Mehta NeuroImage, 2019, 195, 252–260 https://doi.org/10.1016/j.neuroimage.2019.04.007   A B S T R A C T One of the main limitations of pharmacological fMRI is its inability to provide a molecular insight into the main effect of compounds, leaving an open question about the relationship between drug effects and haemodynamic response. The aim of this study is to investigate the acute effects of 3,4-methylene-dioxymethamphetamine (MDMA) on functional [...]

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Psilocybin exerts distinct effects on resting state networks 1 associated with serotonin and dopamine in mice, Joanes Grandjean et al., 2019

Psilocybin exerts distinct effects on resting state networks 1 associated with serotonin and dopamine in mice Joanes Grandjean, David Buehlmann, Michaela Buerge, Hannes Sigrist, Erich Seifritz, Franz X. Vollenweider, Christopher R. Pryce, Markus Rudin Preprint · September 2019 Doi : 10.1101/751255   Abstract Hallucinogenic agents have been proposed as potent antidepressants; this includes the serotonin (5-HT) receptor 2A agonist psilocybin. In human subjects, psilocybin alters functional connectivity (FC) within the default-mode network (DMN), a constellation of inter-connected regions that is involved in self-reference and displays altered FC in depressive disorders. In this study we investigated the effects of psilocybin on FC in the analogue of the [...]

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La recherche sur les microdoses de substances psychédéliques. James Fadiman, Sophie Korbe et les “micro-doses”, Vittorio Biancardi, 2017

La recherche sur les microdoses de substances psychédéliques. James Fadiman, Sophie Korbe et les « micro-doses » Vittorio Biancardi Chimères, 2017/1 N° 91 | pages 139 à148 Les programmes de recherche qui ont été menés légalement sur des dizaines de milliers de patients, à partir de la moitié du vingtième siècle, ont démontré qu’un usage soigneusement réduit de lsd peut se révéler efficace contre certaines psychopathologies, et bénéfique pour le développement personnel et spirituel. En outre, de récentes études ont mis en évidence que la prise de petites doses de lsd peut permettre entre autres une augmentation des capacités cognitives chez des sujets [...]

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Entheogens — Sacramentals or Sacrilege ?, Thomas Roberts, 2012

Entheogens — Sacramentals or Sacrilege ? (a working draft for a syllabus) Thomas ROBERTS in  "Roberts, B. Thomas. (editor) (2012). Spiritual Growth with Entheogens"   To most people who are even moderately experienced with entheogens, concepts such as awe, sacredness, eternity, grace, agapé, transcendence, transfiguration, dark night of the soul, born-again, heaven, and hell are more than theological ideas; they are experiences.   Introduction to Entheogens: Sacramentals or Sacrilege? It should not be necessary to supply more proof that psychedelic drugs produce experiences that those who undergo them regard as religious in the fullest sense. Grinspoon and Bakalar, Psychedelic Drugs Reconsidered Are we experiencing a reorganization in Western religions now, [...]

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Review of Sacred Knowledge : Psychedelics and Religious Experience, William A. Richards, 2016

Review of Sacred Knowledge : Psychedelics and Religious Experience William A. Richards New York, NY: Columbia University Press, 2016. 269 pp. ISBN 978-0-231-17406-0 $29.95 Reviewed by Michael J. Winkelman http://dx.doi.org/10.1037/a0040299   Abstract Reviews the book, Sacred knowledge: Psychedelics and religious experiences, by William A. Richards. Richards’s career of clinical research with psychedelics and professional formation in theology, comparative religion and the psychology of religion bring integrative perspectives to understanding psychedelic experiences. Clinical accounts, scientific research and his personal experiences with psychedelics enable Richards to address issues of core importance in religious studies, medicine and society in general. Clinical studies with psychedelics provide findings that contribute to assessment of [...]

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Scientists mass-produce ‘magic mushroom’ active ingredient from bacteria, ZEM Science, 2019

Scientists mass-produce 'magic mushroom' active ingredient from bacteria The study shows that psilocybin can be produced in a sustainable manner. https://www.zmescience.com/medicine/scientists-mass-produce-magic-mushroom-active-ingredient-from-bacteria/ byTibi Puiu October 3, 2019 Psilocybin, the active psychoactive compound found in specific mushrooms, is a promising drug that can be used to treat depression, anxiety, addiction, and post-traumatic stress disorder. Looking towards the future, researchers at Miami University have used genetic engineering to coax harmless E. coli bacteria to produce psilocybin. Psilocybe semilanceata. Credit: Pixabay. The mushrooms that produce psilocybin, such as Psilocybe cubensis, are not particularly expensive or difficult to grow. However, they do take up a lot of space and require many [...]

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