Mois : mai 2019

MDMA-assisted psychotherapy for treatment of PTSD : study design and rationale for phase 3 trials based on pooled analysis of sixphase 2 randomized controlled trials, Michael C. Mithoefer et al., 2019

MDMA-assisted psychotherapy for treatment of PTSD: study design and rationale for phase 3 trials based on pooled analysis of six phase 2 randomized controlled trials Michael C. Mithoefer, Allison A. Feduccia, Lisa Jerome, Anne Mithoefer, Mark Wagner, Zach Walsh, Scott Hamilton, Berra Yazar-Klosinski, Amy Emerson, Rick Doblin Psychopharmacology, 2019 https://doi.org/10.1007/s00213-019-05249-5 Abstract Background : Posttraumatic stress disorder is a prevalent mental health condition with substantial impact on daily functioning that lacks sufficient treatment options. Here we evaluate six phase 2 trials in a pooled analysis to determine the study design for phase 3 trials of MDMA-assisted psychotherapy for PTSD. Methods : Six randomized, double-blind, controlled clinical trials [...]

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CANNABIS EN TÊTE, “Dopamine”, Mai 2019

CANNABIS EN TÊTE A propos du Dossier Central publié dans le N°237 de la Revue SANTÉ MENTALE "SCHIZOPHRÉNIE ET CANNABIS" - - - - - - - - - - DOPAMINE #05 (MAI 2019)   Sans créer de lien de causalité à la vas-vite, difficile de ne pas associer schizophrénie et usage de cannabis puisqu'un quart des patients souffrants de cette pathologie consomment régulièrement un produit qui n'est peut-être pas entré dans leur vie par hasard ou du moins qu'ils ont adopté pour soulager certains symptômes tout en en aggravant d'autres... Quant à la part de responsabilité du cannabis dans l'apparition d'une schizophrénie, un certain nombre [...]

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Efficacy and Safety of Flexibly Dosed Esketamine Nasal Spray Combined With a Newly Initiated Oral Antidepressant in Treatment-Resistant Depression: A Randomized Double-Blind Active-Controlled Study, Vanina Popova et al., 2019

Efficacy and Safety of Flexibly Dosed Esketamine Nasal Spray Combined With a Newly Initiated Oral Antidepressant in Treatment-Resistant Depression: A Randomized Double-Blind Active-Controlled Study Vanina Popova, M.D., Ella J. Daly, M.D., Madhukar Trivedi, M.D., Kimberly Cooper, M.S., Rosanne Lane, M.A.S., Pilar Lim, Ph.D., Christine Mazzucco, M.Sc., David Hough, M.D., Michael E. Thase, M.D., Richard C. Shelton, M.D., Patricio Molero, M.D., Ph.D., Eduard Vieta, M.D., Ph.D., Malek Bajbouj, M.D., Husseini Manji, M.D., Wayne C. Drevets, M.D., Jaskaran B. Singh, M.D. American Journal of Psychiatry in Advance, 2019 ajp.psychiatryonline.org doi: 10.1176/appi.ajp.2019.19020172   Objective : About one-third of patients with depression fail to achieve remission despite treatment with multiple [...]

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Cannabis thérapeutique : «Tous les voyants sont au vert», Libération, Charles Delouche, 29 mai 2019

Cannabis thérapeutique : «Tous les voyants sont au vert» Par Charles Delouche — 29 mai 2019 à 18:50 Libération Alors que l’Agence nationale du médicament doit rendre son projet d'expérimentation du cannabis thérapeutique fin juin, le Sénat a débattu du sujet ce mercredi à l’initiative d’Esther Benbassa, sénatrice EE-LV de Paris. Battre le fer tant qu’il est chaud. C’est l’idée qui animait le débat sans vote qui s’est déroulé ce mercredi au Sénat autour du cannabis thérapeutique à l'initiative d'Esther Benbassa, sénatrice Europe Ecologie-les Verts (EE-LV) de Paris. La veille, une conférence de presse était organisée aux côtés de [...]

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Cannabidiol, a Cannabis sativa constituent, as an antipsychotic drug, A.W. Zuardi et al., 2006

Cannabidiol, a Cannabis sativa constituent, as an antipsychotic drug A.W. Zuardi, J.A.S. Crippa, J.E.C. Hallak, F.A. Moreira and F.S. Guimarães Brazilian Journal of Medical and Biological Research, 2006, 39, 421-429 ISSN 0100-879X Review Abstract A high dose of Δ9-tetrahydrocannabinol, the main Cannabis sativa (cannabis) component, induces anxiety and psychotic-like symptoms in healthy volunteers. These effects of Δ9-tetrahydrocannabinol are significantly reduced by cannabidiol (CBD), a cannabis constituent which is devoid of the typical effects of the plant. This observation led us to suspect that CBD could have anxiolytic and/or antipsychotic actions. Studies in animal models and in healthy volunteers clearly suggest an anxiolytic-like effect of CBD. The [...]

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Dissociable effects of cannabis with and without cannabidiol on the human brain’s resting-state functional connectivity, Matthew B Wall et al.,

Dissociable effects of cannabis with and without cannabidiol on the human brain’s resting-state functional connectivity Matthew B. Wall, Rebecca Pope, Tom P. Freeman, Oliwia S. Kowalczyk, Lysia Demetriou, Claire Mokrysz, Chandni Hindocha, Will Lawn, Michael A.P. Bloomfield, Abigail M. Freeman, Amanda Feilding, David J. Nutt and H. Valerie Curran Journal of Psychopharmacology,  2019, 1–9 DOI: 10.1177/0269881119841568 journals.sagepub.com/home/jop   Abstract Background : Two major constituents of cannabis are Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD). THC is the main psychoactive component; CBD may buffer the user against the harmful effects of THC. Aims : We examined the effects of two strains of cannabis and placebo on the human brain’s resting-state networks [...]

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Psychedelic therapy in the Czech Republic : A theoretical concept or a realistic goal ?, Zuzana Postranecka et al., 2019

Psychedelic therapy in the Czech Republic : A theoretical concept or a realistic goal ? Zuzana Postranecka, Čestmir Vejmola and Filip Tyls Journal of Psychedelic Studies DOI: 10.1556/2054.2019.003   Abstract Psychedelic research has been associated with the Czech Republic since the early 19th century and, after a long period of involuntary dormancy, it has recently gained new opportunities to follow up on its roots and evolve. This article briefly describes the history of psychedelic research in the Czech Republic, summarizes the role of the UN Drug Conventions, and discusses the Czech and international legislation pertaining to psychedelics. The discussion focuses on the dependence/abuse potential of classical [...]

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Cannabis for refractory epilepsy in children : a review focusing on CDKL5 Deficiency Disorder, Tristan Dale et al., 2019

Cannabis for refractory epilepsy in children : a review focusing on CDKL5 Deficiency Disorder Tristan Dale, Jenny Downs, Heather Olson, Ann Marie Bergin, Stephanie Smith and Helen Leonard Epilepsy Research, 2019 DOI: https://doi.org/doi:10.1016/j.eplepsyres.2019.02.001   Abstract Severe paediatric epilepsies such as CDKL5 Deficiency Disorder (CDD) are extremely debilitating, largely due to the early-onset and refractory nature of the seizures. Existing treatment options are often ineffective and associated with a host of adverse effects, causing those that are affected to seek alternative treatments. Cannabis based products have attracted significant attention over recent years, primarily driven by reports of miraculous cures and a renewed public preference for ‘natural’ therapies, [...]

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Extractions of Medical Cannabis Cultivars and the Role of Decarboxylation in Optimal Receptor Responses, Melissa M. Lewis-Bakker et al., 2019

Extractions of Medical Cannabis Cultivars and the Role of Decarboxylation in Optimal Receptor Responses Melissa M. Lewis-Bakker, Yi Yang, Rupali Vyawahare, and Lakshmi P. Kotra Cannabis and Cannabinoid Research, Volume X, Number X, 2019 Mary Ann Liebert, Inc. DOI: 10.1089/can.2018.0067   Abstract Introduction : Phytocannabinoids, characteristic compounds produced by medical cannabis, interact with cannabinoid (CB) receptors (CB1 and CB2) as well as other receptor systems to exhibit their corresponding pharmacological effects. In their natural form, CBs such as D9-tetrahydrocannabinolic acid and cannabidiolic acid are inactive at these receptors, while their decarboxylated forms (D9 tetrahydrocannabinol and cannabidiol, respectively) are potent ligands at CB receptors. Thus, extraction and processing [...]

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Reduction of Benzodiazepine Use in Patients Prescribed Medical Cannabis, Chad Purcell et al., 2019

Reduction of Benzodiazepine Use in Patients Prescribed Medical Cannabis Chad Purcell, Andrew Davis, Nico Moolman and S. Mark Taylor Cannabis and Cannabinoid Research, Volume 0, Number 0, 2019 Mary Ann Liebert, Inc. DOI: 10.1089/can.2018.0020   Abstract Background : Benzodiazepines are a class of medication with sedative properties, commonly used for anxiety and other neurological conditions. These medications are associated with several well-known adverse effects. This observational study aims to investigate the reduction of benzodiazepine use in patients using prescribed medical cannabis. Methods : A retrospective analysis was performed on a cohort of 146medical cannabis patients (average age 47 years, 61% female, 54% reporting prior use of cannabis) who [...]

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