CBD User's Guide Project CBD On March 13, 2018 (Updated on March 25, 2019) https://www.projectcbd.org/how-to/cbd-users-guide Project CBD has created a beginner’s guide for cannabidiol & cannabis therapeutics to address key questions of CBD users. A Beginner’s Guide to CBD & Cannabis Therapeutics In 2009, a handful of CBD-rich cannabis strains were discovered serendipitously in Northern California, America’s cannabis breadbasket, where certified patients could access medical marijuana legally. Thus began a great laboratory experiment in democracy involving CBD-rich cannabis therapeutics. The advent of whole plant CBD-rich oil as a grassroots therapeutic option has changed the national conversation about cannabis. It’s no longer a question of whether [...]
Lire la suiteChemistry, pharmacology and medicinal properties of Peganum harmala L. Jinous Asgarpanah and Fereshteh Ramezanloo African journal of pharmacy and pharmacology, 2012, 6, (22), 1573-1580. Doi : 10.5897/AJPP11.876 Peganum harmala L. is known as Syrian rue, Wild rue and Harmal. P. harmala extracts are considered important for drug development, because they are reported to have numerous pharmacological activities in the Middle East, especially in Iran and Egypt. For a long time P. harmala has been used in traditional medicines for the relief of pain and as an antiseptic agent. P. harmala also have antibacterial, antifungal, antiviral, antioxidant, antidiabetic, antitumor, antileishmanial, insecticidal and cytotoxic activities and hepatoprotective and antinociceptive effects. Harmaline, [...]
Lire la suiteDistribution, Status, Pharmacological, and Traditional importance of Peganum harmala L. Nissar Ahmad Khan, Aamir Raina, Nasir Aziz Wagay, Younas Rasheed Tantray International Journal of Advance research in Science and Engineering, 2017, 6, (8), 1887-1894. www.ijarse.com ABSTRACT Peganum harmala L. Commonly known as Syrian rue, Wild rue or Harmal is native to arid and semi-arid regions of Northern African and Asian deserts that have spread to parts of the southwestern United States and Northern Mexico. It is a multipurpose medicinal plant with antimicrobial, antifungal, anti inflammatory, antidiabetic, anti cancerous, hypothermic and hallucinogenic activities. Phytochemical investigations has revealed the presences of a number of active alkaloids [...]
Lire la suiteA Chocolate a Day Keeps Depression Away ? Megan Brooks, Laurie Barclay Medscape, 13 / 09 /2019 https://www.medscape.org/viewarticle/917963 Clinical Context Accumulating evidence suggests that dietary factors, such as eating chocolate, may affect depressive symptoms. The potential mood-enhancing properties of chocolate may relate to its orosensory properties, psychoactive ingredients, and activation of neural reward pathways. However, only a few studies have analyzed associations between chocolate consumption and depressive symptoms, with conflicting results. The goal of this analysis was to evaluate associations between chocolate consumption and depressive symptoms in a large, representative sample of US adults enrolled in the US National Health and Nutrition Examination Survey (NHANES) between [...]
Lire la suiteBibliographie : Cannabis et Cannabinoides en Psychiatrie Docteur Christian Sueur, GRECC, décembre 2019. Cannabinoïdes et Anxiété Cannabinoïdes et psychose Cannabinoïdes et dépression Cannabis et addiction 2e version, décembre 2019.... Cannabinoides et PTSD : cf la Bibliographie : Cannabinoïdes et PTSD https://www.grecc.org/publications/bibliographies/bibliographie-cannabinoides-et-ptsd-docteur-christian-sueur-grecc-2019/ Substances psychédéliques et Addictions : cf Bibliographie : Substances psychédéliques et et traitements des Addictions https://www.grecc.org/publications/bibliographies/bibliographie-substances-psychedeliques-et-cannabinoides-et-traitement-des-addictions-dr-christian-sueur-grecc-octobre-2019/
Lire la suiteA Systematic Review on the Pharmacokinetics of Cannabidiol in Humans Sophie A. Millar, Nicole L. Stone, Andrew S. Yates and Saoirse E. O’Sullivan Frontiers in Pharmacology, 26 November 2018 https://doi.org/10.3389/fphar.2018.01365 Background : Cannabidiol is being pursued as a therapeutic treatment for multiple conditions, usually by oral delivery. Animal studies suggest oral bioavailability is low, but literature in humans is not sufficient. The aim of this review was to collate published data in this area. Methods : A systematic search of PubMed and EMBASE (including MEDLINE) was conducted to retrieve all articles reporting pharmacokinetic data of CBD in humans. Results : Of 792 articles retireved, 24 included [...]
Lire la suiteLabeling Accuracy of Cannabidiol Extracts Sold Online Marcel O. Bonn-Miller, Mallory J.E. Loflin, Brian F. Thomas, Jahan P. Marcu, Travis Hyke, Ryan Vandrey JAMA, 2017, Nov 7, 318, (17), 1708–1709. doi: 10.1001/jama.2017.11909 This study compares ingredients listed on the labels of cannabidiol products sold online to actual product constituents determined by laboratory analysis. There is growing consumer demand for cannabidiol (CBD), a constituent of the cannabis plant, due to its purported medicinal benefits for myriad health conditions. Viscous plant-derived extracts, suspended in oil, alcohol (tincture), or vaporization liquid, represent most of the retail market for CBD. Discrepancies between federal and state cannabis laws have resulted in [...]
Lire la suiteTrends in Internet Searches for Cannabidiol (CBD) in the United States Eric C. Leas, Alicia L. Nobles, PhD, Theodore L. Caputi, Mark Dredze, DaveyM. Smith, JohnW. Ayers JAMA Network Open, 2019, 2, (10), e1913853. doi: 10.1001/jamanetworkopen.2019.13853 Introduction Cannabidiol (CBD) is widely promoted as a panacea. For example, the cannabis brand MedMen claims CBD treats acne, anxiety, opioid addiction, pain, and menstrual problems.1 However, the US Food and Drug Administration has only approved highly purified CBD (Epidiolex) for treating epilepsy. To our knowledge, there is currently no population-focused surveillance of public interest in CBD. Consequently, many question whether CBD should be prioritized by public health leaders [...]
Lire la suiteAmanita muscaria: chemistry, biology, toxicology, and ethnomycology Didier MICHELOT, Leda Maria MELENDEZ-HOWELL Mycological Research, 2003, 107, (2), 131-146. https://doi.org/10.1017/S0953756203007305 The fly agaric is a remarkable mushroom in many respects; these are its bearing, history, chemical components and the poisoning that it provokes when consumed. The ‘pantherina’ poisoning syndrome is characterized by central nervous system dysfunction. The main species responsible are Amanita muscaria and A. pantherina (Amanitaceae) ; however, some other species of the genus have been suspected for similar actions. Ibotenic acid and muscimol are the active components, and probably, some other substances detected in the latter species participate in the psychotropic effects. The [...]
Lire la suiteThe Effects of Acutely Administered 3,4-Methylenedioxymethamphetamine on Spontaneous Brain Function in Healthy Volunteers Measured with Arterial Spin Labeling and Blood Oxygen Level–Dependent Resting State Functional Connectivity Robin L. Carhart-Harris, Kevin Murphy, Robert Leech, David Erritzoe, Matthew B. Wall, Bart Ferguson, Luke T.J. Williams, Leor Roseman, Stefan Brugger, Ineke De Meer, Mark Tanner, Robin Tyacke, Kim Wolff, Ajun Sethi, Michael A.P. Bloomfield, Tim M. Williams, Mark Bolstridge, Lorna Stewart, Celia Morgan, Rexford D. Newbould, Amanda Feilding, H. Val Curran, and David J. Nutt Biological Psychiatry, 2015, 78, 554-562. http://dx.doi.org/10.1016/j.biopsych.2013.12.015 ABSTRACT BACKGROUND : The compound 3,4-methylenedioxymethamphetamine (MDMA) is a potent monoamine releaser that produces an acute euphoria in most individuals. METHODS : [...]
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