Étiquette : neurophysiologie

Cannabinomimetric Lipids : From Natural Extract to Artificial Synthesis, Ya-Ru Gao & Yong-Qiang Wang, 2018

Cannabinomimetric Lipids : From Natural Extract to Artificial Synthesis Ya-Ru Gao, Yong-Qiang Wang Natural Products and Bioprospecting, 2018, 8, 1–21 doi : 10.1007/s13659-017-0151-9 Abstract Endocannabinoid system is related with various physiological and cognitive processes including fertility, pregnancy, during pre- and postnatal development, pain-sensation, mood, appetite, and memory. In the latest decades, an important milestone concerning the endocannabinoid system was the discovery of the existence of the cannabinoid receptors CB1 and CB2. Anandamide was the first reported endogenous metabolite, which adjusted the release of some neurotransmitters through binding to the CB1 or CB2 receptors. Then a series of cannabinomimetric lipids were extracted from marine organisms, which [...]

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Research Progress of the Antiviral Bioactivities of Natural Flavonoids, Lin Wang et al., 2020

Research Progress of the Antiviral Bioactivities of Natural Flavonoids Lin Wang · Junke Song · Ailin Liu · Bin Xiao · Sha Li · Zhang Wen · Yang Lu · Guanhua Du Natural Products and Bioprospecting, 2020, 10, 271–283 doi : 10.1007/s13659-020-00257-x Abstract Flavonoids are now considered as an indispensable component in a variety of nutraceutical and pharmaceutical applications. Most recent researches have focused on the health aspects of flavonoids for humans. Especially, different flavonoids have been investigated for their potential antiviral activities, and several natural flavonoids exhibited significant antiviral properties both in vitro and in vivo. This review provides a survey of the literature [...]

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IACM : Le premier webinaire gratuit de l’IACM commence dans 3 heures : Dr Roger Pertwee

Dans 3 heures, le premier webinaire de la série d'événements gratuits de l'IACM commencera, qui se déroulera jusqu'au 3 décembre 2020. Tous les webinaires peuvent être consultés gratuitement jusqu'au 31 mars 2021. Il n'y a donc aucun problème si vous manquez un rendez-vous. O. k. Vous pouvez copier le Magath ici https://new.cannabis-med.org/e2020 15 octobre 2020, 18 heures (CET) Dr. Roger Pertwee Les utilisations thérapeutiques potentielles de certains cannabinoïdes dérivés du cannabis et synthétiques révélées par leurs propriétés pharmacologiques -- Quels sont les médicaments cannabinoïdes approuvés qui ont déjà été développés ? -- Existe-t-il des cannabinoïdes végétaux (phytocannabinoïdes) ayant des propriétés pharmacologiques, pour lesquels des applications thérapeutiques [...]

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The role of cannabinoid transmission in emotional memory formation : implications for addiction and schizophrenia, Huibing Tan et al., 2014

The role of cannabinoid transmission in emotional memory formation: implications for addiction and schizophrenia Huibing Tan, Tasha Ahmad, Michael Loureiro, Jordan Zunder and Steven R. Laviolette Frontiers in Psychiatry, 2014,Vol 5, Article 73, 1-12 doi : 10.3389/fpsyt.2014.00073   Emerging evidence from both basic and clinical research demonstrates an important role for endo-cannabinoid (ECB) signaling in the processing of emotionally salient information, learning, and memory. Cannabinoid transmission within neural circuits involved in emotional processing has been shown to modulate the acquisition, recall, and extinction of emotionally salient memories and importantly, can strongly modulate the emotional salience of incoming sensory information. Two neural regions in particular, the [...]

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Recent Advances in the Neuropsychopharmacology of Serotonergic Hallucinogens, Adam L. Halberstadt, 2015

Recent Advances in the Neuropsychopharmacology of Serotonergic Hallucinogens Adam L. Halberstadt Behavioral Brain Research, 2015, 15, 277, 99–120. doi : 10.1016/j.bbr.2014.07.016   Abstract Serotonergic hallucinogens, such as (+)-lysergic acid diethylamide, psilocybin, and mescaline, are somewhat enigmatic substances. Although these drugs are derived from multiple chemical families, they all produce remarkably similar effects in animals and humans, and they show cross-tolerance. This article reviews the evidence demonstrating the serotonin 5-HT2A receptor is the primary site of hallucinogen action. The 5-HT2A receptor is responsible for mediating the effects of hallucinogens in human subjects, as well as in animal behavioral paradigms such as drug discrimination, head twitch response, prepulse [...]

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What Can We Learn About Schizophrenia From Studying the Human Model, Drug-Induced Psychosis ?, Robin M. Murray et al., 2013

What Can We Learn About Schizophrenia From Studying the Human Model, Drug-Induced Psychosis ? Robin M. Murray, Alessandra Paparelli, Paul D. Morrison, Arianna Marconi, and Marta Di Forti American Journal of Medical Genetics, Part B, 2013, 162B, 661–670. Doi : 10.1002/ajmg.b.32177   When drug-induced psychoses were first identified in the mid- 20th century, schizophrenia was considered a discrete disease with a likely genetic cause. Consequently, drug-induced psychoses were not considered central to understanding schizophrenia as they were thought to be phenocopies rather than examples of the illness secondary to a particular known cause. However, now that we know that schizophrenia is a clinical syndrome with [...]

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Cannabinoids : Extraction Methods, Analysis and Physicochemical Characterization, Cristina Lujan RAMIREZ et al., 2019, ,

Cannabinoids : Extraction Methods, Analysis and Physicochemical Characterization Cristina Lujan RAMIREZ, Maria Alejandra FANOVICH, Maria Sandra CHURIO. Studies in Natural Products Chemistry, Chapter 4, 2019, Volume 61, 143-173 (1-44). Doi : 10.1016/B978-0-444-64183-0.00004-X ABSTRACT : A new paradigm has been established in the application of cannabinoids in the last decade. The growing accessibility to different types of Cannabis products and the rise in concern about their health benefits have provoked a rapid expansion of the research interests in phytocannabinoids with promising pharmacological properties. The characterization of the diverse chemotypes of Cannabis sativa, the elucidation of their various structures, and quantification of cannabinoids in the complex [...]

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Beneficial Effects of Cannabis on Blood Brain Barrier Function in HIV, Ronald J. ELLIS et al., 2020

Beneficial Effects of Cannabis on Blood Brain Barrier Function in HIV Ronald J Ellis  1 , Scott Peterson  2 , Mariana Cherner  1 , Erin Morgan  1 , Rachel Schrier  1 , Bin Tang  1 , Martin Hoenigl  1 , Scott Letendre  1 , Jenny Iudicello  1 Clinical infectious diseases, 2020 Apr 16, ciaa437. Doi : 10.1093/cid/ciaa437 Abstract Background: HIV infection leads to blood-brain barrier (BBB) dysfunction that does not resolve despite viral suppression on antiretroviral therapy and is associated with adverse clinical outcomes. In preclinical models, cannabis restores BBB integrity. Methods: We studied people with HIV (PWH) and HIV- individuals who had used cannabis [...]

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Astrocytes in rapid ketamine antidepressant action, Matjaž Stenovec et al., 2020

Astrocytes in rapid ketamine antidepressant action Matjaž Stenovec, Baoman Li, Alexei Verkhratsky, Robert Zorec Neuropharmacology, 2020, 173, 108158 Doi : 10.1016/j.neuropharm.2020.108158   H I G H L I G H T S • Ketamine inhibits calcium signalling and enhances cAMP production in astroglia. • Ketamine suppresses exocytosis of gliosignalling molecules and Kir4.1. • Ketamine elevates cholesterol content in the plasmalemma specifically in astrocytes. A B S T R A C T Ketamine, a general anaesthetic and psychotomimetic drug, exerts rapid, potent and long-lasting antidepressant effect, albeit the cellular and molecular mechanisms of this action are yet to be discovered. Besides targeting neuronal NMDARs fundamental for synaptic transmission, ketamine affects the [...]

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BIBLIOGRAPHIE : Substances psychédéliques : Généralités, Épistémologie, Pharmacologie, Neurophysiologie, Psychologie…, Dr Christian SUEUR, GRECC, mai 2020 (nouvelle version)

BIBLIOGRAPHIE : Substances psychédéliques : Généralités, Épistémologie, Pharmacologie, Neurophysiologie, Psychologie, … Dr Christian SUEUR, GRECC, mai 2020 (nouvelle version)   Substances psychédéliques : Généralités, Pharmacologie, Neurophysiologie : 1 - 17 Substances psychédéliques et «psychologie » : 18 - 20   Cf également : Bibliographie : Thérapies psychédéliques, Bibliographie : Substances psychédéliques, culture, chamanisme, spiritualité, religion… Bibliographie : Psilocybine, Bibliographie : LSD, Bibliographie : Ayahuasca, Bibliographie : Mescaline et Peyotl, Bibliographie : MDMA, Bibliographie : Tryptamines …

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