Étiquette : neurophysiologie

Ayahuasca in Adolescence : A Neuropsychological Assessment, Evelyn Doering-Silveira, Charles S. Grob et al., 2005

Ayahuasca in Adolescence : A Neuropsychological Assessment Evelyn Doering-Silveira, Enrique Lopez,  Charles S. Grob, Marlene Dobkin de Rios, Luisa K. Alonso, Cristiane Tacla,Itiro Shirakawa,  Paulo H. Bertolucci,  & Dartiu X. Da Silveira Journal of Psychoactive Drugs, 2005, 37, (2), 123-128.   Abstract The purpose of the study was to evaluate neuropsychologically adolescents who use ayahuasca in a religious context. A battery of neuropsychological tests was administered to adolescents who use ayahuasca. These subjects were compared to a matched control group of adolescents who did not use ayahuasca. The controls were matched with regards to sex, age, and education. The neuropsychological battery included tests of speeded [...]

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Effects of a Psychedelic, Tropical Tea, Ayahuasca, on the Electroencephalographic (EEG) Activity of the Human Brain during a Shamanistic Ritual, Erik Hoffmann et al., 2001

Effects of a Psychedelic, Tropical Tea, Ayahuasca, on the Electroencephalographic (EEG) Activity of the Human Brain during a Shamanistic Ritual Erik Hoffmann, Jan M. Keppel Hesselink, Yatra-W.M. da Silveira Barbosa MAPS Bulletin, Multidisciplinary Association for Psychedelic Studies, USA, Spring 2001, pp 25-30   Abstract Eight channels of EEG from 12 volunteers participating in a workshop in Brazil were recorded under field conditions before and after a shamanistic ritual in which the psychoactive tea, ayahuasca, was consumed. Following three doses of the tea, the subjects showed strong and statistically significant increases of both EEG alpha (8-13Hz) and theta (4-8Hz) mean amplitudes compared to baseline while beta [...]

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Receptor-Enriched Analysis of functional connectivity by targets (REACT) : A novel, multimodal analytical approach informed by PET to study the pharmacodynamic response of the brain under MDMA, Ottavia Dipasquale et al., 2019

Receptor-Enriched Analysis of functional connectivity by targets (REACT) : A novel, multimodal analytical approach informed by PET to study the pharmacodynamic response of the brain under MDMA Ottavia Dipasquale, Pierluigi Selvaggi, Mattia Veronese, Anthony S. Gabay, Federico Turkheimer, Mitul A. Mehta NeuroImage, 2019, 195, 252–260 https://doi.org/10.1016/j.neuroimage.2019.04.007   A B S T R A C T One of the main limitations of pharmacological fMRI is its inability to provide a molecular insight into the main effect of compounds, leaving an open question about the relationship between drug effects and haemodynamic response. The aim of this study is to investigate the acute effects of 3,4-methylene-dioxymethamphetamine (MDMA) on functional [...]

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Psilocybin exerts distinct effects on resting state networks 1 associated with serotonin and dopamine in mice, Joanes Grandjean et al., 2019

Psilocybin exerts distinct effects on resting state networks 1 associated with serotonin and dopamine in mice Joanes Grandjean, David Buehlmann, Michaela Buerge, Hannes Sigrist, Erich Seifritz, Franz X. Vollenweider, Christopher R. Pryce, Markus Rudin Preprint · September 2019 Doi : 10.1101/751255   Abstract Hallucinogenic agents have been proposed as potent antidepressants; this includes the serotonin (5-HT) receptor 2A agonist psilocybin. In human subjects, psilocybin alters functional connectivity (FC) within the default-mode network (DMN), a constellation of inter-connected regions that is involved in self-reference and displays altered FC in depressive disorders. In this study we investigated the effects of psilocybin on FC in the analogue of the [...]

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The Role of MDMA Neurotoxicity in Anxiety, Casey R. Guillot et al., 2007

The Role of MDMA Neurotoxicity in Anxiety Casey R. Guillot, Mitchell E. Berman and Brenton R. Abadie In : Neurotoxicity Syndromes, Chapter I ISBN: 978-1-60021-797-5 Editor: Linda R. Webster, pp. 1 - 36 © 2007 Nova Science Publishers, Inc. Abstract The drug 3,4-methylenedioxymethamphetamine (MDMA; Ecstasy) long has been considered a neurotoxin selective for serotonin (5-hydroxytryptamine; 5-HT) axons in rats and nonhuman primates. MDMA is also thought to have the potential to cause persistent serotonergic alterations in humans. Since the serotonin system is involved in the regulation of anxiety, researchers have proposed that recreational Ecstasy users may be at risk for the development of anxiety disorders and symptoms. [...]

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The endocannabinoid system : an overview, Natalia Battista et al., 2012

The endocannabinoid system : an overview Natalia Battista, Monia Di Tommaso, Monica Bari and Mauro Maccarrone Frontiers in Behavioral Neuroscience, 2012|Volume 6|Article 9 | 1 doi: 10.3389/fnbeh.2012.00009   Upon the identification of anandamide (AEA) in the porcine brain, numerous studies contributed to the current state of knowledge regarding all elements that form the “endocannabinoidsystem (ECS).” How this complex system of receptors, ligands, and enzymes is integrated in helping to regulate fundamental processes at level of central nervous and peripheral systems and how its regulation and dysregulation might counteract disturbances of such functions, is now a days still under investigation. However, the most recent advances on [...]

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Cannabidiol attenuates seizures and EEG abnormalities in Angelman syndrome, Bin GU et al., 2019 model mice,

Cannabidiol attenuates seizures and EEG abnormalities in Angelman syndrome model mice. Bin Gu, Manhua Zhu, Madison R. Glass, Marie Rougié, Viktoriya D. Nikolova, Sheryl S. Moy, Paul R. Carney, and Benjamin D. Philpot Journal of Clinical Investigation, 2019 Sep 10, pii: 130419. doi : 10.1172/JCI130419 PMID : 31503547 Abstract Angelman syndrome (AS) is a neurodevelopmental disorder characterized by intellectual disability, lack of speech, ataxia, EEG abnormalities, and epilepsy. Seizures in AS individuals are common, debilitating, and often drug-resistant. Therefore, there is an unmet need for better treatment options. Cannabidiol (CBD), a major phytocannabinoid constituent of cannabis, has antiseizure activity and behavioral benefits in preclinical and [...]

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Heavy cannabis use, dependence and the brain : a clinical perspective, Emese Kroon et al., 2019

Heavy cannabis use, dependence and the brain : a clinical perspective Emese Kroon, Lauren Kuhns, Eva Hoch & Janna Cousijn Addictions, 2019, 1-12. doi : 10.1111/add.14776   ABSTRACT Aims : To summarize and evaluate our knowledge of the relationship between heavy cannabis use, cannabis use disorder (CUD) and the brain. Methods : Narrative review of relevant literature identified through existing systematic reviews, meta-analyses and a PubMed search. Epidemiology, clinical representations, potential causal mechanisms, assessments, treatment and prognosis are discussed. Results : Although causality is unclear, heavy and dependent cannabis use is consistently associated with a high prevalence of comorbid psychiatric disorders and learning and memory impairments that seem [...]

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Psychedelics as Medicines for Substance Abuse Rehabilitation : Evaluating Treatments with LSD, Peyote, Ibogaine and Ayahuasca Michael Winkelman, 2014

Psychedelics as Medicines for Substance Abuse Rehabilitation : Evaluating Treatments with LSD, Peyote, Ibogaine and Ayahuasca Michael Winkelman Current Drug Abuse Reviews, 2014, 7, 101-116   Abstract : Substances known as psychedelics, hallucinogens and entheogens have been employed in ethnomedical traditions for thousands of years, but after promising uses in the 1950’s and 1960’s they were largely prohibited in medical treatment and human research starting in the 1970’s as part of the fallout from the war on drugs. Nonetheless, there are a number of studies which suggest that these substances have potential applications in the treatment of addictions. While these substances are generally classified as [...]

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From local to global—Fifty years of research on Salvia divinorum, Ivan Casselman et al., 2014

From local to global—Fifty years of research on Salvia divinorum Ivan Casselman, Catherine J. Nock, Hans Wohlmuth, Robert P. Weatherby, Michael Heinrich Journal of Ethnopharmacology, 2014, 151, 768–783 http://dx.doi.org/10.1016/j.jep.2013.11.032   a b s t r a c t Ethnopharmacological relevance : In 1962 ethnopharmacologists, Hofmann and Wasson, undertook an expedition to Oaxaca,Mexico. These two researchers were the first scientists to collecta flowering specimen of Salvia divinorum allowing theidentification ofthisspecies.Whilet he species'traditional use is confined to a very small region of Mexico, since Hofmann and Wasson's expedition 50 years ago, Salvia divinorum has become globally recognized for its main active constituent, the diterpene salvinorin A, which has [...]

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