Catégorie : Cannabidiol

Clinicians’ Guide to Cannabidiol and Hemp Oils, Harrison J. VanDolah et al., 2019

Clinicians’ Guide to Cannabidiol and Hemp Oils Harrison J. VanDolah, Brent A. Bauer, and Karen F. Mauck  Mayo Clinic Proceedings, 2019, 94, (9), 1840-1851 https://doi.org/10.1016/j.mayocp.2019.01.003   Abstract Cannabidiol (CBD) oils are low tetrahydrocannabinol products derived from Cannabis sativa that have become very popular over the past few years. Patients report relief for a variety of conditions, particularly pain, without the intoxicating adverse effects of medical marijuana. In June 2018, the first CBD-based drug, Epidiolex, was approved by the US Food and Drug Administration for treatment of rare, severe epilepsy, further putting the spotlight on CBD and hemp oils. There is a growing body of preclinical and [...]

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Opioïdes : le cannabidiol pour réduire la dépendance ?, RESPADD, Actualités des Addictions n°100, juillet 2019

Opioïdes  : le cannabidiol pour réduire la dépendance ? Le cannabidiol (CBD) réduit le craving et l'anxiété chez les personnes ayant des antécédents d'abus d'héroïne/opioïdes, suggérant un rôle possible du cannabis ou de son agent le cannabidiol dans la réduction de la dépendance aux opioïdes. C’est la conclusion de cette étude réalisée à l’Icahn School of Medicine du Mont Sinaï (New York), présentée dans l'American Journal of Psychiatry. L'étude confirme également les effets anti-stress du CBD avec une baisse de la fréquence cardiaque et du taux de cortisol induites par les stimuli de drogues.   La grande disponibilité des opioïdes sur prescription ces [...]

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Cannabidiol Does Not Dampen Responses to Emotional Stimuli in Healthy Adults, David L. Arndt and Harriet de Wit, 2017

Cannabidiol Does Not Dampen Responses to Emotional Stimuli in Healthy Adults David L. Arndt and Harriet de Wit Cannabis and Cannabinoid Research, 2017, 2, (1), 105-113 DOI: 10.1089/can.2017.0014 Abstract Introduction : Cannabidiol (CBD) is a nonpsychoactive constituent of whole plant cannabis that has been reported to reduce anxiety-like behaviors in both pre-clinical and human laboratory studies. Yet, no controlled clinical studies have demonstrated its ability to reduce negative mood or dampen responses to negative emotional stimuli in humans. The objective of this study was to investigate the effects of CBD on responses to negative emotional stimuli, as a model for its potential anxiety-reducing effects. Materials and [...]

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Chanvre industriel, bien-être, cannabis médical, récréatif : pourquoi ces distinctions ?, Aurélien Bernard, NEWSWEED, Cannabis en France, 18 juillet 2019

Chanvre industriel, bien-être, cannabis médical, récréatif : pourquoi ces distinctions ? Aurélien Bernard NEWSWEED, Cannabis en France 18 juillet 2019 Une question nous est revenue à plusieurs reprises suite au récapitulatif du colloque sur le chanvre bien-être : pourquoi parler de « chanvre bien-être » ? Si l’on peut effectivement s’interroger sur la nécessité d’avoir toutes ces dénominations, elles servent pourtant à dissocier à la fois les usages et l’aspect réglementaire franco-français du cannabis. Nous avons donc : du chanvre industriel : variétés de cannabis à -0,2% de THC, pour un usage fibres et graines du chanvre bien-être : variétés de cannabis à -0,2% de [...]

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How Adolescents with Autism Spectrum Disorder (ASD) Spontaneously Attend to Real-World Scenes : Use of a Change Blindness Paradigm, Michal Hochhauser et al., 2018

How Adolescents with Autism Spectrum Disorder (ASD) Spontaneously Attend to Real-World Scenes : Use of a Change Blindness Paradigm Michal Hochhauser, Adi Aran, Ouriel Grynszpan Journal of Autism and Developmental Disorders, 2018, 48, 502–510 DOI 10.1007/s10803-017-3343-6 https://www.researchgate.net/publication/320647151_How_Adolescents_with_Autism_Spectrum_Disorder_ASD_Spontaneously_Attend_to_Real-World_Scenes_Use_of_a_Change_Blindness_Paradigm [accessed Jul 16 2019].   Abstract Visual attention of adolescents with autism spectrum disorder (ASD) was assessed using a change blind-ness paradigm. Twenty-five adolescents with ASD aged 12–18 years and 25 matched typically developing (TD) adolescents viewed 36 pairs of digitized real-world images. Each pair of images was displayed in a ‘flicker paradigm’ whereby a particular item alternately appeared and disappeared. This item was either a central or a marginal [...]

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How effective and safe is medical cannabis as a treatment of mental disorder ? A systematic review, Eva HOCH et al., 2019

How effective and safe is medical cannabis as a treatment of mental disorder ? A systematic review HOCH E., NIEMANN D., von KELLER R., SCHNEIDER M., FRIEMEL C.M., PREUSS U.W., HASAN A., POGARELL O. European Archives of Psychiatry and Clinical Neuroscience, 2019 https://doi.org/10.1007/s00406-019-00984-4   Abstract We conducted a review of systematic reviews (SRs) and randomized-controlled trials (RCTs) to analyze efficacy and safety of cannabis-based medication in patients with mental disorders. Five data bases were systematically searched (2006—August 2018); 4 SRs (of 11 RCTs) and 14 RCTs (1629 participants) were included. Diagnoses were: dementia, cannabis and opioid dependence, psychoses/schizophrenia, general social anxiety, posttraumatic stress disorder, anorexia nervosa, [...]

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Novel insights into mitochondrial molecular targets of iron-induced neurodegeneration: Reversal by cannabidiol, Vanessa Kappel da Silva et al., 2018

Novel insights into mitochondrial molecular targets of iron-inducedneurodegeneration: Reversal by cannabidiol Vanessa Kappel da Silva, Betânia Souza de Freitas, Victória Campos Dornelles,Luiza Wilges Kist, Maurício Reis Bogoc, Milena Carvalho Silvad, Emílio Luiz Streck, Jaime Eduardo Hallak, Antônio Waldo Zuardib,e, José Alexandre S. Crippab,e,Nadja Schrödera Brain Research Bulletin, 2018, 139, 1–8 https://doi.org/10.1016/j.brainresbull.2018.01.014   ABSTRACT Evidence has demonstrated iron accumulation in specific brain regions of patients suffering from neurodegen-erative disorders, and this metal has been recognized as a contributing factor for neurodegeneration. Using anexperimental model of brain iron accumulation, we have shown that iron induces severe memory deficits thatare accompanied by oxidative stress, increased apoptotic markers, and decreased [...]

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The neuroprotection of cannabidiol against MPP+-induced toxicity inPC12 cells involves trkA receptors, upregulation of axonal and synapticproteins, neuritogenesis, and might be relevant to Parkinson’s disease, Neife Aparecida Guinaim Santos et al., 2015

The neuroprotection of cannabidiol against MPP+-induced toxicity inPC12 cells involves trkA receptors, upregulation of axonal and synapticproteins, neuritogenesis, and might be relevant to Parkinson's disease Neife Aparecida Guinaim Santos, Nádia Maria Martins, Flávia Malvestio Sisti, Laís Silva Fernandes, Rafaela Scalco Ferreira, Regina Helena Costa Queiroz, Antônio Cardozo Santos Toxicology in Vitro, 2015, 30, 231–240. http://dx.doi.org/10.1016/j.tiv.2015.11.004 a b s t r a c t Cannabidiol (CBD) is a non-psychoactive constituent of Cannabis sativa with potential to treat neurodegenerative diseases. Its neuroprotection has beenmainly associated with anti-inflammatory and antioxidant events; however, other mechanisms might be involved. We investigated the involvement of neuritogenesis, NGF receptors (trkA), NGF, and [...]

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Cannabidiol provides long-lasting protection against the deleterious effects of inflammation in a viral model of multiple sclerosis : A role for A2A receptors, M. Mecha et al., 2013

Cannabidiol provides long-lasting protection against the deleterious effects of inflammation in a viral model of multiple sclerosis : A role for A2A receptors M. Mecha, A. Feliú, P.M. Iñigo, L. Mestre, F.J. Carrillo-Salinas, C. Guaza Neurobiology of Disease, 2013, 59, 141–150 https://doi.org/10.1016/j.nbd.2013.06.016   Inflammation in the central nervous system (CNS) is a complex process that involves a multitude of mole-cules and effectors, and it requires the transmigration of blood leukocytes across the blood–brain barrier(BBB) and the activation of resident immune cells. Cannabidiol (CBD), a non-psychotropic cannabinoid constituent of Cannabis sativa, has potent anti-inflammatory and immunosuppressive properties. Yet, how this compound modifies the deleterious effects of [...]

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Evidences for the Anti-panic Actions of Cannabidiol, Vanessa P. Soares and Alline C. Campos, 2017

Evidences for the Anti-panic Actions of Cannabidiol Vanessa P. Soares and Alline C. Campos Current Neuropharmacology, 2017, 15, 291-299 DOI : 10.2174/1570159X14666160509123955   Abstract : Background : Panic disorder (PD) is a disabling psychiatry condition that affects approximately 5% of the worldwide population. Currently, long-term selective serotonin reuptake inhibitors (SSRIs) are the first-line treatment for PD; however, the common side-effect profiles and drug interactions may provoke patients to abandon the treatment, leading to PD symptoms relapse. Cannabidiol (CBD) is the major non-psychotomimetic constituent of the Cannabis sativa plant with antianxiety properties that has been suggested as an alternative for treating anxiety disorders. The aim of the [...]

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