Catégorie : Pharmacologie

A tale of two cannabinoids : The therapeutic rationale for combining tetrahydrocannabinol and cannabidiol, Ethan Russo & Geoffrey W. Guy, 2006

A tale of two cannabinoids : The therapeutic rationale for combining tetrahydrocannabinol and cannabidiol Ethan Russo & Geoffrey W. Guy Medical Hypotheses, 2006, 66, 234–246 doi : 10.1016/j.mehy.2005.08.026 Summary This study examines the current knowledge of physiological and clinical effects of tetrahydrocannabinol (THC) and cannabidiol (CBD) and presents a rationale for their combination in pharmaceutical preparations. Cannabinoid and vanilloid receptor effects as well as non-receptor mechanisms are explored, such as the capability of THC and CBD to act as anti-inflammatory substances independent of cyclo-oxygenase (COX) inhibition. CBD is demonstrated to antagonise some undesirable effects of THC including intoxication, sedation and tachycardia, while contributing analgesic, anti-emetic, [...]

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Interaction of maternal choline levels and prenatal Marijuana’s effects on the offspring, Camille Hoffman et al., 2019

Interaction of maternal choline levels and prenatal Marijuana's effects on the offspring Camille Hoffman, Sharon K. Hunter, Angelo D'Alessandro, KathleenNoonan et al. Psychological Medicine, 2019 Doi : https://doi.org/10.1017/S003329171900179X Published online by Cambridge University Press: 31 July 2019 Abstract Background : This study investigated whether higher maternal choline levels mitigate effects of marijuana on fetal brain development. Choline transported into the amniotic fluid from the mother activates α7-nicotinic acetylcholine receptors on fetal cerebro-cortical inhibitory neurons, whose development is impeded by cannabis blockade of their cannabinoid-1(CB1) receptors. Methods : Marijuana use was assessed during pregnancy from women who later brought their newborns for study. Mothers were informed about [...]

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Cannabis and the developing brain : Insights from behavior, Viviana Trezza et al., 2008

Cannabis and the developing brain : Insights from behavior Viviana Trezza, Vincenzo Cuomo, Louk J.M.J. Vanderschuren European Journal of Pharmacology, 2008, 585, 441-452. Doi : 10.1016/j.ejphar.2008.01.058   A B S T R A C T The isolation and identification, in 1964, of delta-9-tetrahydrocannabinol (THC), the primary psycho-active compound in cannabis, opened the door to a whole new field of medical research. The exploration of the therapeutic potential of THC and other natural and synthetic cannabinoid compounds was paralleled by the discovery of the endocannabinoid system, comprising cannabinoid receptors and their endogenous ligands, which offered exciting new insights into brain function. Besides its well-known involvement in specific [...]

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Developmental consequences of perinatal cannabis exposure : behavioral and neuroendocrine effects in adult rodents, Patrizia Campolongo et al., 2011

Developmental consequences of perinatal cannabis exposure : behavioral and neuroendocrine effects in adult rodents Patrizia Campolongo, Viviana Trezza, Patrizia Ratano, Maura Palmery & Vincenzo Cuomo Psychopharmacology, 2011, 214, 5–15 Doi : 10.1007/s00213-010-1892-x   Abstract Rationale : Cannabis is the most commonly used illicit drug among pregnant women. Since the endocannabinoid system plays a crucial role in brain development, maternal exposure to cannabis derivatives might result in longlasting neurobehavioral abnormalities in the exposed offspring. It is difficult to detect these effects, and their underlying neurobiological mechanisms, in clinical cohorts, because of their intrinsic methodological and interpretative issues. Objectives : The present paper reviews relevant rodent studies examining the [...]

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A novel phytocannabinoid isolated from Cannabis sativa L. with an in vivo cannabimimetic activity higher than Δ9-tetrahydrocannabinol : Δ9-Tetrahydrocannabiphorol, Cinzia Citti et al., 2019

A novel phytocannabinoid isolated from Cannabis sativa L. with an in vivo cannabimimetic activity higher than Δ9-tetrahydrocannabinol : Δ9-Tetrahydrocannabiphorol Cinzia Citti, Pasquale Linciano, Fabiana Russo, Livio Luongo, Monica Iannotta, Sabatino Maione, Aldo Laganà, Anna Laura Capriotti, Flavio Forni, Maria Angela Vandelli, Giuseppe Gigli & Giuseppe Cannazza Scientific Reports, 2019, 9, 20335 doi : 10.1038/s41598-019-56785-1 2   (-)-Trans-Δ9-tetrahydrocannabinol (Δ9-THC) is the main compound responsible for the intoxicant activity of Cannabis sativa L. The length of the side alkyl chain influences the biological activity of this cannabinoid. In particular, synthetic analogues of Δ9-THC with a longer side chain have shown cannabimimetic properties far higher than Δ9-THC itself. [...]

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Changing landscape of cannabis : novel products, formulations, and methods of administration, Tory R Spindle et al., 2019

Changing landscape of cannabis : novel products, formulations, and methods of administration Tory R Spindle, Marcel O Bonn-Miller and Ryan Vandrey Current Opinion in Psychology, 2019, 30, 98–102 Doi : 10.1016/j.copsyc.2019.04.002   Abstract Laws regulating cannabis have changed radically in the U.S. and abroad. Historically, users smoked dried cannabis flowers that contained D9-tetrahydrocannabinol (THC), the primary psychoactive component of cannabis, as the principal product constituent. Coincident with cannabis legalization and increased interest in medicinal use of the plant, there is now an expansive retail cannabis marketplace with novel cannabis products, formulations, and methods of administration. In this review, we describe emergent cannabis product chemotypes (e.g. THC-dominant, [...]

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Association Between Recreational Cannabis Use and Cardiac Structure and Function, Mohammed Y. Khanji et al., 2019

Association Between Recreational Cannabis Use and Cardiac Structure and Function Mohammed Y. Khanji, Magnus T. Jensen, Asmaa A. Kenawy, Zahra Raisi-Estabragh, Jose M. Paiva, Nay Aung, Kenneth Fung, Elena Lukaschuk, Filip Zemrak, Aaron M. Lee, Ahmet Barutcu, Edd Maclean, Jackie Cooper, Stefan K. Piechnik, Stefan Neubauer and Steffen E. Petersen JACC : Cardiovascular Imaging, 2019. Doi : 10.1016/j.jcmg.2019.10.012   LETTER TO THE EDITOR Cannabis is one of the most widely produced and consumed recreational drugs in the world, with over 192 million global users (1). The World Health Organization has warned against the potential harmful health effects of nonmedicinal cannabis use and highlighted the need for more [...]

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Associations Between Marijuana Use and Cardiovascular Risk Factors and Outcomes : A Systematic Review, Divya Ravi et al., 2018

Associations Between Marijuana Use and Cardiovascular Risk Factors and Outcomes : A Systematic Review Divya Ravi, MD, MPH; Mehrnaz Ghasemiesfe, MD; Deborah Korenstein, MD; Thomas Cascino, MD; and Salomeh Keyhani, MD, MPH Annals of Internal Medicine, 2018, 168, (3), 187-194. doi : 10.7326/M17-1548      Annals.org Abstract Background : Marijuana use is increasing in the United States, and its effect on cardiovascular health is unknown. Purpose : To review harms and benefits of marijuana use in relation to cardiovascular risk factors and clinical outcomes. Data Sources : PubMed, MEDLINE, EMBASE, PsycINFO, and the Cochrane Library between 1 January 1975 and 30 September 2017. Study Selection : Observational studies that were published [...]

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