Catégorie : Publications

Minor Cannabinoids of Cannabis sativa L., Fabian Thomas & Oliver Kayser, 2019

Minor Cannabinoids of Cannabis sativa L. Fabian Thomas & Oliver Kayser Journal of Medical Science, 2019, 88, (3), 141-149. Doi : 10.20883/jms.367   ABSTRACT Cannabinoids from Cannabis sativa L. play an important role as natural products in clinics. The major cannabinoids compromise tetrahydrocannabinolic acid (THCA) and cannabidiolic acid (CBDA) and its decarboxylated analogs. In this review, we focus on often neglected minor cannabinoids and discuss biosynthetic and chemical degradation routes to other neglected cannabinoids in Cannabis sativa starting from THCA, CBDA and cannabichromenic acid (CBCA). Based on the literature, patents and scientific reports, essential routes for the chemical modifi cation of cannabinoids are discussed to explain [...]

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Cannabis sativa L. CANNABACEAE, Rainer W. Bussmann et al., 2020

Cannabis sativa L. CANNABACEAE Rainer W. Bussmann, Ketevan Batsatsashvili, Zaal Kikvidze, Narel Y. Paniagua-Zambrana, Manana Khutsishvili, Inesa Maisaia, Shalva Sikharulidze, and David Tchelidze © Springer Nature Switzerland AG 2020 in K. Batsatsashvili et al. (eds.), Ethnobotany of the Mountain Regions of Far Eastern Europe, Ethnobotany of Mountain Regions, doi : 10.1007/978-3-030-28940-9_33 Synonyms : Cannabis sativa L., Cannabis chinense Delile, Cannabis indica Lam, Cannabis sativa var. indica (Lam.) E. Small & Cronquist R. Local Names : Georgian : კანაფი (k’anapi); ქან (qan) (Grossheim 1952; Ketskhoveli et al. 1971–2011; Makashvili 1991; Fedorov 1984); English : Cannabis Botany and Ecology Annual; stems 50–150 cm, covered with appressed hairs; leaves long petioled, [...]

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Ayahuasca : Uses, Phytochemical and Biological Activities, Edgar Antonio Estrella‑Parra et al., 2019

Ayahuasca : Uses, Phytochemical and Biological Activities Edgar Antonio Estrella‑Parra · Julio Cesar Almanza‑Pérez · Francisco Javier Alarcón‑Aguilar Natural Products and Bioprospecting, 2019, 9, 251–265 doi : 10.1007/s13659-019-0210-5   Abstract Ayahuasca (caapi, yajé), is a psychoactive brew from the Amazon Basin region of South America traditionally considered a “master plant.” It is prepared as a decoction from Banisteriopsis caapi and Psychotria viridis, which it is thought that it stimulates creative thinking and visual creativity. Native healers of the Orinoco and Amazon basins have used traditionally ayahuasca as a healing tool for multiple purposes, particularly to treat psychological disorders in the patients, with some beneficial effects experimentally [...]

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Role of the endogenous cannabinoid system in nicotine addiction : novel insights, Islam Hany Gamaleddin et al., 2015

Role of the endogenous cannabinoid system in nicotine addiction : novel insights Islam Hany Gamaleddin, Jose M.Trigo, Aliou B. Gueye, Alexander Zvonok, Alexandros Makriyannis, Steven R. Goldberg and Bernard Le Foll Frontiers in Psychiatry, 2015, Vol 6, Article 41, 1-12. doi : 10.3389/fpsyt.2015.00041 Several lines of evidence have shown that the endogenous cannabinoids are implicated in several neuropsychiatric diseases. Notably, preclinical and human clinical studies have shown a pivotal role of the cannabinoid system in nicotine addiction. The CB1 receptor inverse agonist/antagonist rimonabant (also known as SR141716)was effective to decrease nicotine-taking and nicotine-seeking in rodents, as well as the elevation of dopamine induced by [...]

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Cannabinomimetric Lipids : From Natural Extract to Artificial Synthesis, Ya-Ru Gao & Yong-Qiang Wang, 2018

Cannabinomimetric Lipids : From Natural Extract to Artificial Synthesis Ya-Ru Gao, Yong-Qiang Wang Natural Products and Bioprospecting, 2018, 8, 1–21 doi : 10.1007/s13659-017-0151-9 Abstract Endocannabinoid system is related with various physiological and cognitive processes including fertility, pregnancy, during pre- and postnatal development, pain-sensation, mood, appetite, and memory. In the latest decades, an important milestone concerning the endocannabinoid system was the discovery of the existence of the cannabinoid receptors CB1 and CB2. Anandamide was the first reported endogenous metabolite, which adjusted the release of some neurotransmitters through binding to the CB1 or CB2 receptors. Then a series of cannabinomimetric lipids were extracted from marine organisms, which [...]

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Research Progress of the Antiviral Bioactivities of Natural Flavonoids, Lin Wang et al., 2020

Research Progress of the Antiviral Bioactivities of Natural Flavonoids Lin Wang · Junke Song · Ailin Liu · Bin Xiao · Sha Li · Zhang Wen · Yang Lu · Guanhua Du Natural Products and Bioprospecting, 2020, 10, 271–283 doi : 10.1007/s13659-020-00257-x Abstract Flavonoids are now considered as an indispensable component in a variety of nutraceutical and pharmaceutical applications. Most recent researches have focused on the health aspects of flavonoids for humans. Especially, different flavonoids have been investigated for their potential antiviral activities, and several natural flavonoids exhibited significant antiviral properties both in vitro and in vivo. This review provides a survey of the literature [...]

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Determination of cannabinoids in Cannabis sativa L. samples for recreational, medical, and forensic purposes by reversed-phase liquid chromatography-ultraviolet detection, Sanja Zivovinovic, et al., 2018

Determination of cannabinoids in Cannabis sativa L. samples for recreational, medical, and forensic purposes by reversed-phase liquid chromatography-ultraviolet detection Sanja Zivovinovic, Ruth Alder, Martina D. Allenspach and Christian Steuer Journal of Analytical Science and Technology, 2018, 9, 27, 1-10 doi : 10.1186/s40543-018-0159-8   Abstract Background : Currently, an increasing demand of cannabis-derived products for recreational and medical use is observed. Therefore, the reliable and fast quantification of cannabinoids in hemp samples is essential for the control of product from Cannabis sativa, L. strains. In general, gas chromatography (GC) is the method of choice for the quantification of cannabinoids whereas this method is time consuming and the [...]

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Δ 9‑Tetrahydrocannabinol Toxicity and Validation of Cannabidiol on Brain Dopamine Levels : An Assessment on Cannabis Duplicity, Swapnali Chetia & Gaurab Borah, 2020

Δ 9‑Tetrahydrocannabinol Toxicity and Validation of Cannabidiol on Brain Dopamine Levels : An Assessment on Cannabis Duplicity Swapnali Chetia · Gaurab Borah Natural Products and Bioprospecting, 2020, 10, 285–296 doi : 10.1007/s13659-020-00263-z   Abstract Δ9-tetrahydrocannabinol (THC) of cannabis is the main psychoactive component which is a global significant concern to human health. Evaluation on THC reported its drastic effect on the brain dopaminergic (DAergic) system stimulating mesolimbic DA containing neurons thereby increasing the level of striatal DA. Cannabidiol (CBD), with its anxiolytic and anti-psychotic property, is potent to ameliorate the THC-induced DAergic variations. Legal authorization of cannabis use and its analogs in most countries led to [...]

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IACM : Le premier webinaire gratuit de l’IACM commence dans 3 heures : Dr Roger Pertwee

Dans 3 heures, le premier webinaire de la série d'événements gratuits de l'IACM commencera, qui se déroulera jusqu'au 3 décembre 2020. Tous les webinaires peuvent être consultés gratuitement jusqu'au 31 mars 2021. Il n'y a donc aucun problème si vous manquez un rendez-vous. O. k. Vous pouvez copier le Magath ici https://new.cannabis-med.org/e2020 15 octobre 2020, 18 heures (CET) Dr. Roger Pertwee Les utilisations thérapeutiques potentielles de certains cannabinoïdes dérivés du cannabis et synthétiques révélées par leurs propriétés pharmacologiques -- Quels sont les médicaments cannabinoïdes approuvés qui ont déjà été développés ? -- Existe-t-il des cannabinoïdes végétaux (phytocannabinoïdes) ayant des propriétés pharmacologiques, pour lesquels des applications thérapeutiques [...]

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Décret no 2020-1230 du 7 octobre 2020 relatif à l’expérimentation de l’usage médical du cannabis NOR : SSAP2021390D

Décret no 2020-1230 du 7 octobre 2020 relatif à l’expérimentation de l’usage médical du cannabis NOR : SSAP2021390D Décrets, arrêtés, circulaires TEXTES GÉNÉRAUX MINISTÈRE DES SOLIDARITÉS ET DE LA SANTÉ JOURNAL OFFICIEL DE LA RÉPUBLIQUE FRANÇAISE, le 9 octobre 2020   Publics concernés: professionnels de santé et patients inclus dans l’expérimentation; entreprises ou organismes exploitant un médicament ou un produit; entreprises pharmaceutiques exerçant une activité de distribution en gros de médicaments; Agence nationale de sécurité du médicament et des produits de santé. Objet: modalités de mise en oeuvre de l’expérimentation relative à l’usage médical du cannabis. Entrée en vigueur: le texte entre en vigueur le lendemain [...]

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