Étiquette : psychédéliques

Reviewing the Potential of Psychedelics for the Treatment of PTSD, Erwin Krediet et al., 2020

Reviewing the Potential of Psychedelics for the Treatment of PTSD Erwin Krediet, Tijmen Bostoen, Joost Breeksema, Annette van Schagen, Torsten Passie, Eric Vermetten International Journal of Neuropsychopharmacology, 2020, 23, (6), 385–400 doi : 10.1093/ijnp/pyaa018 https://pubmed.ncbi.nlm.nih.gov/32170326/   Abstract There are few medications with demonstrated efficacy for the treatment of posttraumatic stress disorder (PTSD). Treatment guidelines have unequivocally designated psychotherapy as a first line treatment for PTSD. Yet, even after psychotherapy, PTSD often remains a chronic illness, with high rates of psychiatric and medical comorbidity. Meanwhile, the search for and development of drugs with new mechanisms of action has stalled. Therefore, there is an urgent need to explore not [...]

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The potential synergistic effects between psychedelic administration and nature contact for the improvement of mental health, Sam Gandy et al, 2020

The potential synergistic effects between psychedelic administration and nature contact for the improvement of mental health Sam Gandy, Matthias Forstmann, Robin Lester Carhart-Harris, Christopher Timmermann, David Luke and Rosalind Watts Health Psychology Open, 2020, 1–21 Doi : 10.1177/2055102920978123   Abstract Therapeutic psychedelic administration and contact with nature have been associated with the same psychological mechanisms : decreased rumination and negative affect, enhanced psychological connectedness and mindfulness related capacities, and heightened states of awe and transcendent experiences, all processes linked to improvements in mental health amongst clinical and healthy populations. Nature-based settings can have inherently psychologically soothing properties which may complement all stages of psychedelic therapy (mainly [...]

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Effects of external stimulation on psychedelic state neurodynamics, Pedro A.M. Mediano et al., 2020

Effects of external stimulation on psychedelic state neurodynamics Pedro A.M. Mediano, Fernando E. Rosas, Christopher Timmermann, Leor Roseman, David J. Nutt, Amanda Feilding, Mendel Kaelen, Morten L. Kringelbach, Adam B. Barretti, Anil K. Seth, Suresh Muthukumaraswamy, Daniel Bor, and Robin L. Carhart-Harris bioRxiv preprint, 2020 doi : 10.1101/2020.11.01.356071   Abstract Recent findings have shown that psychedelics reliably enhance brain entropy (understood as neural signal diversity), and this effect has been associated with both acute and long-term psychological outcomes such as personality changes. These findings are particularly intriguing given that a decrease of brain entropy is a robust indicator of loss of consciousness (e.g. from wakefulness to [...]

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Post-acute psychological effects of classical serotonergic psychedelics : a systematic review and meta-analysis, Simon B. Goldberg et al, 2020,

Post-acute psychological effects of classical serotonergic psychedelics: a systematic review and meta-analysis Simon B. Goldberg, Benjamin Shechet, Christopher R. Nicholas, Chi Wing Ng, Geetanjali Deole, Zhuofan Chen and Charles L. Raison Psychological Medicine, 2020, 1–12. doi : 10.1017/S003329172000389X   Abstract Background. Scientific interest in the therapeutic effects of classical psychedelics has increased in the past two decades. The psychological effects of these substances outside the period of acute intoxication have not been fully characterized. This study aimed to: (1) quantify the effects of psilocybin, ayahuasca, and lysergic acid diethylamide (LSD) on psychological outcomes in the post-acute period; (2) test moderators of these effects; and (3) evaluate [...]

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Mystical Experiences in Retrospective Reports of First Times Using a Psychedelic in Finland, Samuli Kangaslampi et al., 2020

Mystical Experiences in Retrospective Reports of First Times Using a Psychedelic in Finland Samuli Kangaslampi, PhD , Aino Hausen, BA, and Tarina Rauteenmaa, BA JOURNAL OF PSYCHOACTIVE DRUGS, 2020, 1-10 Doi : 10.1080/02791072.2020.1767321   ABSTRACT Despite their acutely inebriating and sometimes unpleasant effects, some people report positive changes in life satisfaction, well-being, or mental health after taking psychedelic drugs. One explanation may be the ability of psychedelics to trigger mystical-type experiences. We examined the validity, reliability, and factor structure of a novel Finnish translation of the Revised Mystical Experiences Questionnaire (MEQ30) among 288 people retrospectively reporting on their first time using a psychedelic. We found evidence [...]

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Adverse Reactions to Psychedelic Drugs. A Review of the Literature, Rick J. STRASSMAN, 1984.

Adverse Reactions to Psychedelic Drugs. A Review of the Literature Rick J. STRASSMAN, M.D. THE JOURNAL OF NERVOUS AND MENTAL DISEASE, 1984, VOL. 172, NO. 10, 577-595. DOI : 10.1097/00005053-198410000-00001   The use of naturally occurring and synthetically derived compounds for their "psychedelic" effects has been a part of human culture for thousands of years. The basic pharmacology of the major synthetic psychedelic compounds primarily lysergic acid diethylamide [LSD]-25 is described and reference is made to their potentially beneficial psychological effects. Adverse reactions, defined as dysphoric and/or maladaptive/dysfunctional responses to the use of these drugs, sometimes require careful clinical judgment in order to diagnose. These reactions [...]

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Recent Advances in the Neuropsychopharmacology of Serotonergic Hallucinogens, Adam L. Halberstadt, 2015

Recent Advances in the Neuropsychopharmacology of Serotonergic Hallucinogens Adam L. Halberstadt Behavioral Brain Research, 2015, 15, 277, 99–120. doi : 10.1016/j.bbr.2014.07.016   Abstract Serotonergic hallucinogens, such as (+)-lysergic acid diethylamide, psilocybin, and mescaline, are somewhat enigmatic substances. Although these drugs are derived from multiple chemical families, they all produce remarkably similar effects in animals and humans, and they show cross-tolerance. This article reviews the evidence demonstrating the serotonin 5-HT2A receptor is the primary site of hallucinogen action. The 5-HT2A receptor is responsible for mediating the effects of hallucinogens in human subjects, as well as in animal behavioral paradigms such as drug discrimination, head twitch response, prepulse [...]

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BIBLIOGRAPHIE : Substances psychédéliques : anthropologie, sociologie, spiritualité, chamanisme, culture…, Docteur Christian Sueur, GRECC, mai 2020

BIBLIOGRAPHIE : Substances psychédéliques : anthropologie, sociologie, spiritualité, chamanisme, culture…   Docteur Christian Sueur, GRECC, mai 2020   Substances psychédéliques, anthropologie, sociologie, culture… : pp 1 - 6 Substances psychédéliques et Chamanisme : pp 7 - 10 Psychédéliques et “spiritualité” : religion, mysticisme, enthéogènes : pp 11 - 23  

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BIBLIOGRAPHIE : Substances psychédéliques : Généralités, Épistémologie, Pharmacologie, Neurophysiologie, Psychologie…, Dr Christian SUEUR, GRECC, mai 2020 (nouvelle version)

BIBLIOGRAPHIE : Substances psychédéliques : Généralités, Épistémologie, Pharmacologie, Neurophysiologie, Psychologie, … Dr Christian SUEUR, GRECC, mai 2020 (nouvelle version)   Substances psychédéliques : Généralités, Pharmacologie, Neurophysiologie : 1 - 17 Substances psychédéliques et «psychologie » : 18 - 20   Cf également : Bibliographie : Thérapies psychédéliques, Bibliographie : Substances psychédéliques, culture, chamanisme, spiritualité, religion… Bibliographie : Psilocybine, Bibliographie : LSD, Bibliographie : Ayahuasca, Bibliographie : Mescaline et Peyotl, Bibliographie : MDMA, Bibliographie : Tryptamines …

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De la première vague à la renaissance psychédélique, Dr Bertrand LEBEAU, ATHS 2019

De la première vague à la renaissance psychédélique ATHS 2019, Biarritz, 1-4 octobre 2019 Dr Bertrand LEBEAU LEIBOVICI     Les psychédéliques « classiques » A l’exception du LSD, ce sont des substances naturelles consommées par certains peuples depuis des millénaires Les psychédéliques « classiques » interagissent avec le récepteur 5HT2a : LSD psilocybine DMT (Diméthyltryptamine) mescaline Une définition plus large des psychédéliques : Les entactogènes et empathogènes: MDMA, MDA, 2-CB, 2C-T-7 etc. Les substances dissociatives antagonistes NMDA : kétamine, PCP Les substances dissociatives agonistes kappa-opioïdes : ibogaïne et Salvia Divinorum Tryptamines et phényléthylamines : Les psychédéliques sont : soit des tryptamines : LSD, psilocybine, DMT, ibogaïne, bufoténine (5-hydroxy-DMT) soit des phényléthylamines: MDMA, mescaline, MDA, 2C-B etc. La psychiatrie en [...]

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