Étiquette : phytocannabinoïdes

Cannabinoids, Phenolics, Terpenes and Alkaloids of Cannabis, Mohamed M. Radwan et al., 2021

Cannabinoids, Phenolics, Terpenes and Alkaloids of Cannabis Mohamed M. Radwan, Suman Chandra, Shahbaz Gul and Mahmoud A. ElSohly Molecules, 2021, 26, 2774. Doi : 10.3390/molecules26092774   Abstract : Cannabis sativa is one of the oldest medicinal plants in the world. It was introduced into western medicine during the early 19th century. It contains a complex mixture of secondary metabolites, including cannabinoids and non-cannabinoid-type constituents. More than 500 compounds have been reported from C. sativa, of which 125 cannabinoids have been isolated and/or identified as cannabinoids. Cannabinoids are C21 terpeno phenolic compounds specific to Cannabis. The non-cannabinoid constituents include: non-cannabinoid phenols, flavonoids, terpenes, alkaloids and others. This review discusses [...]

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Protective Effects of Cannabidivarin and Cannabigerol on Cells of the Blood–Brain Barrier Under Ischemic Conditions, Nicole L. Stone et al., 2021

Protective Effects of Cannabidivarin and Cannabigerol on Cells of the Blood–Brain Barrier Under Ischemic Conditions Nicole L. Stone, Timothy J. England, and Saoirse E. O’Sullivan Cannabis and Cannabinoid Research, 2021, Doi : 10.1089/can.2020.0159   Abstract Background and Objectives : Preclinical studies have shown cannabidiol is protective in models of ischemic stroke. Based on results from our recent systematic review, we investigated the effects of two promising neuroprotective phytocannabinoids, cannabigerol (CBG) and cannabidivarin (CBDV), on cells of the blood–brain barrier (BBB), namely human brain microvascular endothelial cells (HBMECs), pericytes, and astrocytes. Experimental Approach : Cultures were subjected to oxygen-glucose deprivation (OGD) protocol to model ischemic stroke and cell [...]

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Absence of Entourage : Terpenoids Commonly Found in Cannabis sativa Do Not Modulate the Functional Activity of Δ9-THC at Human CB1 and CB2 Receptors, Marina Santiago et al., 2019

Absence of Entourage : Terpenoids Commonly Found in Cannabis sativa Do Not Modulate the Functional Activity of Δ9-THC at Human CB1 and CB2 Receptors Marina Santiago, Shivani C. Arnold, Iain S., McGregor and Mark Connor Cannabis and Cannabinoid Research, 2019, Vol. 4, No. 3 doi : 10.1089/can.2019.0016 Abstract Introduction: Compounds present in Cannabis sativa such as phytocannabinoids and terpenoids may act in concert to elicit therapeutic effects. Cannabinoids such as Δ9-tetrahydrocannabinol (Δ9-THC) directly activate cannabinoid receptor 1 (CB1) and cannabinoid receptor 2 (CB2); however, it is not known if terpenoids present in Cannabis also affect cannabinoid receptor signaling. Therefore, we examined six common terpenoids alone, [...]

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Cannabis sativa L. as a Natural Drug Meeting the Criteria of a Multitarget Approach to Treatment, Anna Stasiłowicz et al., 2021

Cannabis sativa L. as a Natural Drug Meeting the Criteria of a Multitarget Approach to Treatment Anna Stasiłowicz, Anna Tomala, Irma Podolak and Judyta Cielecka-Piontek International Journal of Molecular Sciences, 2021, 22, 778. Doi : 10.3390/ijms22020778 Abstract : Cannabis sativa L. turned out to be a valuable source of chemical compounds of various structures, showing pharmacological activity. The most important groups of compounds include phytocannabinoids and terpenes. The pharmacological activity of Cannabis (in epilepsy, sclerosis multiplex (SM), vomiting and nausea, pain, appetite loss, inflammatory bowel diseases (IBDs), Parkinson’s disease, Tourette’s syndrome, schizophrenia, glaucoma, and coronavirus disease 2019 (COVID-19)), which has been proven so far, results [...]

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Clinical and Preclinical Evidence for Functional Interactions of Cannabidiol and Δ9-Tetrahydrocannabinol, Douglas L Boggs et al., 2018

Clinical and Preclinical Evidence for Functional Interactions of Cannabidiol and Δ9-Tetrahydrocannabinol Douglas L Boggs, Jacques D Nguyen, Daralyn Morgenson, Michael A Taffe and Mohini Ranganathan Neuropsychopharmacology Reviews, 2018, 43, 142–154. doi : 10.1038/npp.2017.209; The plant Cannabis sativa, commonly called cannabis or marijuana, has been used for its psychotropic and mind-altering side effects for millennia. There has been growing attention in recent years on its potential therapeutic efficacy as municipalities and legislative bodies in the United States, Canada, and other countries grapple with enacting policy to facilitate the use of cannabis or its constituents for medical purposes. There are 4550 chemical compounds and 4100 phytocannabinoids [...]

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That which we call Indica, by any other name would smell as sweet. An essay on the history of the term Indica and the taxonomical conflict between the monotypic and polytypic views of Cannabis, Jacob L. Erkelens, Arno Hazekamp, 2014

That which we call Indica, by any other name would smell as sweet. An essay on the history of the term Indica and the taxonomical conflict between the monotypic and polytypic views of Cannabis Jacob L. Erkelens, Arno Hazekamp Bedrocan BV, The Netherlands Cannabinoids, 2014, 9, (1), 9-15. What’s in a name ? An interesting feature of the worldwide subculture devoted to cannabis is the endless number of names given to its preparations (marijuana, pot, weed, kiff, bhang..). On top of that, there is a continuously grow-ing list of names used to describe different varieties and strains of the cannabis plant. As a result of [...]

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Early phytocannabinoid chemistry to endocannabinoids and beyond, Raphael Mechoulam et al, 2014

Early phytocannabinoid chemistry to endocannabinoids and beyond Raphael Mechoulam, Lumír O. Hanuš, Roger Pertwee and Allyn C. Howlett NATURE REVIEWS | NEUROSCIENCE, 2014, 15, 757-764. Doi : 10.1038/nrm3811   Abstract Isolation and structure elucidation of most of the major cannabinoid constituents — including Δ9-tetrahydrocannabinol (Δ9-THC), which is the principal psychoactive molecule in Cannabis sativa — was achieved in the 1960s and 1970s. It was followed by the identification of two cannabinoid receptors in the 1980s and the early 1990s and by the identification of the endocannabinoids shortly thereafter. There have since been considerable advances in our understanding of the endocannabinoid system and its function in the [...]

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Minor Cannabinoids of Cannabis sativa L., Fabian Thomas & Oliver Kayser, 2019

Minor Cannabinoids of Cannabis sativa L. Fabian Thomas & Oliver Kayser Journal of Medical Science, 2019, 88, (3), 141-149. Doi : 10.20883/jms.367   ABSTRACT Cannabinoids from Cannabis sativa L. play an important role as natural products in clinics. The major cannabinoids compromise tetrahydrocannabinolic acid (THCA) and cannabidiolic acid (CBDA) and its decarboxylated analogs. In this review, we focus on often neglected minor cannabinoids and discuss biosynthetic and chemical degradation routes to other neglected cannabinoids in Cannabis sativa starting from THCA, CBDA and cannabichromenic acid (CBCA). Based on the literature, patents and scientific reports, essential routes for the chemical modifi cation of cannabinoids are discussed to explain [...]

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Cannabis sativa L. CANNABACEAE, Rainer W. Bussmann et al., 2020

Cannabis sativa L. CANNABACEAE Rainer W. Bussmann, Ketevan Batsatsashvili, Zaal Kikvidze, Narel Y. Paniagua-Zambrana, Manana Khutsishvili, Inesa Maisaia, Shalva Sikharulidze, and David Tchelidze © Springer Nature Switzerland AG 2020 in K. Batsatsashvili et al. (eds.), Ethnobotany of the Mountain Regions of Far Eastern Europe, Ethnobotany of Mountain Regions, doi : 10.1007/978-3-030-28940-9_33 Synonyms : Cannabis sativa L., Cannabis chinense Delile, Cannabis indica Lam, Cannabis sativa var. indica (Lam.) E. Small & Cronquist R. Local Names : Georgian : კანაფი (k’anapi); ქან (qan) (Grossheim 1952; Ketskhoveli et al. 1971–2011; Makashvili 1991; Fedorov 1984); English : Cannabis Botany and Ecology Annual; stems 50–150 cm, covered with appressed hairs; leaves long petioled, [...]

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Determination of cannabinoids in Cannabis sativa L. samples for recreational, medical, and forensic purposes by reversed-phase liquid chromatography-ultraviolet detection, Sanja Zivovinovic, et al., 2018

Determination of cannabinoids in Cannabis sativa L. samples for recreational, medical, and forensic purposes by reversed-phase liquid chromatography-ultraviolet detection Sanja Zivovinovic, Ruth Alder, Martina D. Allenspach and Christian Steuer Journal of Analytical Science and Technology, 2018, 9, 27, 1-10 doi : 10.1186/s40543-018-0159-8   Abstract Background : Currently, an increasing demand of cannabis-derived products for recreational and medical use is observed. Therefore, the reliable and fast quantification of cannabinoids in hemp samples is essential for the control of product from Cannabis sativa, L. strains. In general, gas chromatography (GC) is the method of choice for the quantification of cannabinoids whereas this method is time consuming and the [...]

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