Catégorie : Dossiers scientifiques

Synthetic Pot : Not Your Grandfather’s Marijuana, Benjamin M. Ford et al, 2017

Synthetic Pot : Not Your Grandfather’s Marijuana Benjamin M. Ford, Sherrica Tai, William E. Fantegrossi, and Paul L. Prather Trends in Pharmacological Sciences, 2017, 38, (3), 257–276. doi : 10.1016/j.tips.2016.12.003 Abstract In the early 2000’s in Europe and shortly thereafter in the USA, it was reported that “legal” forms of marijuana were being sold under the name K2 and/or Spice. Active ingredients in K2/Spice products were determined to be synthetic cannabinoids (SCBs), producing psychotropic actions via CB1 cannabinoid receptors, similar to those of Δ9-THC, the primary active constituent in marijuana. Often abused by adolescents and military personnel to elude detection in drug tests due to [...]

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Synthetic and Non-synthetic Cannabinoid Drugs and Their Adverse Effects-A Review From Public Health Prospective, Koby Cohen and Aviv M. Weinstein, 2018

Synthetic and Non-synthetic Cannabinoid Drugs and Their Adverse Effects-A Review From Public Health Prospective Koby Cohen and Aviv M. Weinstein Frontiers in Public Health, 2018, Volume 6 | Article 162 doi : 10.3389/fpubh.2018.00162 There is a growing use of novel psychoactive substances containing synthetic cannabinoids. Synthetic cannabinoid products have effects similar to those of natural cannabis, yet, these drugs are more potent and dangerous, and have been associated with dangerous adverse effects. Here, we review current literature on the epidemiology, acute, and chronic effects of synthetic and natural cannabinoid-based drugs. Synthetic drugs contain a mixture of psychoactive compounds that mostly bind cannabinoid receptors with [...]

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Cannabinoïdes synthétiques, www.psychoactif.org/psychowiki,

Cannabinoïdes synthétiques https://www.psychoactif.org/psychowiki/index.php?title=Cannabino%C3%AFdes_synth%C3%A9tiques   Les cannabinoïdes synthétiques sont des molécules de synthèse qui agissent d'une façon proche de celle des cannabinoïdes végétaux, naturellement présents dans le cannabis (comme le THC)[1]. Ce sont principalement des agonistes des récepteurs cannabinoïdes. La plupart ont été développés à des fins thérapeutiques (analgésie), d’autres ont été synthétisés dans le but de créer des alternatives légales au cannabis. Les cannabinoïdes synthètiques sont la classe la plus importante des nouveaux produits de synthèse. Sur les 73 nouvelles substances de synthèses reportées par le EMCDDA en 2012, 30 étaient des cannabinoïdes de synthèse. De 2008 à mai 2013, 84 cannabinoïdes de synthèse ont [...]

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Nouveaux produits de synthèse – Synthèse des connaissances, www.ofdt.fr, 2018

Nouveaux produits de synthèse - Synthèse des connaissances Copyright © Observatoire Français des Drogues et des Toxicomanies, mai 2018 https://www.drogues.gouv.fr/publication/nouvelles-substances-psychoactives-un-guide-services-durgences   Présentation L’abréviation NPS est généralement utilisée en France en référence aux Nouveaux Produits de synthèse. Ils désignent un éventail très hétérogène de substances qui imitent les effets de différents produits illicites (ecstasy, amphétamines, cocaïne, cannabis, etc.). Leurs structures moléculaires s’en rapprochent, sans être tout à fait identiques. Cette spécificité leur permet, au moins à court terme, de contourner la législation sur les stupéfiants ; certains sont classés, d’autres n’ont pas de statut juridique clair. Généralement achetés sur Internet, les NPS sont connus soit par leurs noms [...]

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Cannabinoids and Reproduction : A Lasting and Intriguing History, Giovanna Cacciola et al, 2010

Cannabinoids and Reproduction : A Lasting and Intriguing History Giovanna Cacciola, Rosanna Chianese, Teresa Chioccarelli, Vincenza Ciaramella, Silvia Fasano, Riccardo Pierantoni, RosariaMeccariello and Gilda Cobellis Pharmaceuticals, 2010, 3, 3275-3323. doi : 10.3390/ph3103275   Abstract : Starting from an historical overview of lasting Cannabis use over the centuries, we will focus on a description of the cannabinergic system, with a comprehensive analysis of chemical and pharmacological properties of endogenous and synthetic cannabimimetic analogues. The metabolic pathways and the signal transduction mechanisms, activated by cannabinoid receptors stimulation, will also be discussed. In particular, we will point out the action of cannabinoids and endocannabinoids on the different neuronal networks [...]

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Circulation d’herbe de cannabis adultérée avec des cannabinoïdes de synthèse, Note SINTES, 2020

Circulation d’herbe de cannabis adultérée avec des cannabinoïdes de synthèse Victor Detrez - Magali Martinez Note SINTES - Octobre 2020, 2 p.   Depuis l’été 2019, plusieurs pays européens ont observé la circulation de résine et d’herbe de cannabis très faiblement dosées en Δ-9-tetrahydrocannabinol (THC), avec ou non du cannabidiol (CBD), adultérées avec des cannabinoïdes de synthèse (Autriche, Suisse)1. Ces produits sont vendus de façon trompeuse comme du simple cannabis. En France, ce phénomène a été rapporte par plusieurs associations (en Provence-Alpes-Côte d’Azur et Bourgogne-Franche-Comte), sans qu’il y ait eu des analyses sur le territoire français jusqu’à maintenant. Ces herbes ou résines ont un [...]

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The experimental effects of psilocybin on symptoms of anxiety and depression : A meta-analysis, Simon B. Goldberg et al, 2020

The experimental effects of psilocybin on symptoms of anxiety and depression : A meta-analysis Simon B. Goldberg, Brian T. Pace, Christopher R. Nicholas, Charles L. Raison, Paul R. Hutson Psychiatry Research, 2020, 284,  112749 Doi : 10.1016/j.psychres.2020.112749   A B S T R A C T The current meta-analysis examined the effects of psilocybin in combination with behavioral interventions on anxiety and depression in samples with elevated symptoms. Across four studies (one uncontrolled; three randomized, placebo-controlled; N = 117), within-group pre-post and pre-follow-up effects on anxiety and depression were large (Hedges’ gs=1.16 to 1.47) and statistically significant. Across three placebo-controlled studies, pre-post placebo-controlled effects were also [...]

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Post-acute psychological effects of classical serotonergic psychedelics : a systematic review and meta-analysis, Simon B. Goldberg et al, 2020,

Post-acute psychological effects of classical serotonergic psychedelics: a systematic review and meta-analysis Simon B. Goldberg, Benjamin Shechet, Christopher R. Nicholas, Chi Wing Ng, Geetanjali Deole, Zhuofan Chen and Charles L. Raison Psychological Medicine, 2020, 1–12. doi : 10.1017/S003329172000389X   Abstract Background. Scientific interest in the therapeutic effects of classical psychedelics has increased in the past two decades. The psychological effects of these substances outside the period of acute intoxication have not been fully characterized. This study aimed to: (1) quantify the effects of psilocybin, ayahuasca, and lysergic acid diethylamide (LSD) on psychological outcomes in the post-acute period; (2) test moderators of these effects; and (3) evaluate [...]

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Use of Genetically Informed Methods to Clarify the Nature of the Association Between Cannabis Use and Risk for Schizophrenia, Nathan A. Gillespie, Kenneth S. Kendler, 2020

Use of Genetically Informed Methods to Clarify the Nature of the Association Between Cannabis Use and Risk for Schizophrenia Nathan A. Gillespie, Kenneth S. Kendler JAMA Psychiatry,  Published online November 4, 2020   Cohort studies and meta-analyses have documented a robust association between cannabis use, heavy use, and misuse with future risk of schizophrenia.1-3 Despite adjusting for covariates, including current psychotic symptoms, other psychopathology, and social integration,(1) the ability of these models to determine the degree to which cannabis causes schizophrenia is limited and dependent on their ability to capture all relevant confounders. When evaluating efforts to reduce cannabis use as a means of [...]

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Pharmacological evaluation of new constituents of “Spice”: synthetic cannabinoids based on indole, indazole, benzimidazole and carbazole scaffolds, Clara T. Schoeder et al., 2018

Pharmacological evaluation of new constituents of “Spice”: synthetic cannabinoids based on indole, indazole, benzimidazole and carbazole scaffolds Clara T. Schoeder, Cornelius Hess, Burkhard Madea, Jens Meiler, Christa E. Müller Forensic Toxicology, 2018, 36, 385-403. Doi : 10.1007/s11419-018-0415-z   Abstract Purpose : In the present study we characterized a series of synthetic cannabinoids containing various heterocyclic scaffolds that had been identified as constituents of “Spice”, a preparation sold on the illicit drug market. All compounds were further investigated as potential ligands of the orphan receptors GPR18 and GPR55 that interact with some cannabinoids. Methods : The compounds were studied in radioligand binding assays to determine their affinity for [...]

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