Étiquette : psychothérapie

Acute Effects of Lysergic Acid Diethylamide in Healthy Subjects, Yasmin Schmid et al., 2014,

Acute Effects of Lysergic Acid Diethylamide in Healthy Subjects Yasmin Schmid, Florian Enzler, Peter Gasser, Eric Grouzmann, Katrin H. Preller, Franz X. Vollenweider, Rudolf Brenneisen, Felix Müller, Stefan Borgwardt, and Matthias E. Liechti Biological Psychiatry, 2014, Vol. 78, 8, 544-553 http://dx.doi.org/10.1016/j.biopsych.2014.11.015   ABSTRACT BACKGROUND : After no research in humans for .40 years, there is renewed interest in using lysergic acid diethylamide (LSD) in clinical psychiatric research and practice. There are no modern studies on the subjective and autonomic effects of LSD, and its endocrine effects are unknown. In animals, LSD disrupts prepulse inhibition (PPI) of the acoustic startle response, and patients with schizophrenia exhibit similar [...]

Lire la suite

Implications for psychedelic-assisted psychotherapy : functional magnetic resonnance imaging study with psilocybin, Robin L. Carhart-Harris et al., 2012

Implications for psychedelic-assisted psychotherapy : a functional magnetic resonance imaging study with psilocybin R. L. Carhart-Harris, R. Leech, T. M. Williams, D. Erritzoe, N. Abbasi, T. Bargiotas, P. Hobden, D. J. Sharp, J. Evans, A. Feilding, R. G. Wise and D. J. Nutt British Journal of Psychiatry, 2012, 200, 238-244. Doi : 10.1192/bjp.bp.111.103309   Background Psilocybin is a classic psychedelic drug that has a history of use in psychotherapy. One of the rationales for its use was that it aids emotional insight by lowering psychological defences. Aims To test the hypothesis that psilocybin facilitates access to personal memories and emotions by comparing subjective and neural responses to positive [...]

Lire la suite

Reduction in social anxiety after MDMA-assisted psychotherapy with autistic adults: a randomized, double-blind, placebo-controlled pilot study, Alicia L. Danforth, Charles S. Grob et al., 2018

Reduction in social anxiety after MDMA-assisted psychotherapy with autistic adults : a randomized, double-blind, placebo-controlled pilot study Alicia L. Danforth, Charles S. Grob, Christopher Struble, Allison A. Feduccia, Nick Walker, Lisa Jerome, Berra Yazar-Klosinski & Amy Emerson Psychopharmacology, 2018, https://doi.org/10.1007/s00213-018-5010-9   Abstract Rationale : Standard therapeutic approaches to reduce social anxiety in autistic adults have limited effectiveness. Since 3,4- methylenedioxymethamphetamine (MDMA)-assisted psychotherapy shows promise as a treatment for other anxiety disorders, a blinded, placebo-controlled pilot study was conducted. Objectives : To explore feasibility and safety ofMDMA-assisted psychotherapy for reduction of social fear and avoidance that are common in the autistic population. Methods : Autistic adults with marked to [...]

Lire la suite

Developing Guidelines and Competencies for the Training of Psychedelic Therapists, Janis Phelps, 2017

Developing Guidelines and Competencies for the Training of Psychedelic Therapists Janis Phelps Journal of Humanistic Psychology, 2017, 1–38 DOI: 10.1177/0022167817711304   Abstract Research since the 1950s has shown that psychedelic-assisted psychotherapy has had significant positive effects in reductions of specific clinical symptoms and increases in quality of life as measured on a variety of indices. The intensity of focus on evidence-based outcomes, however, has resulted in a paucity of active discussions and research on the core competencies of the therapists themselves. The context of the history of psychedelic research reveals how this neglect of therapist variables occurred. With current discussions of Phase 3 and expanded access [...]

Lire la suite

Efficacy and Enlightenment: LSD Psychotherapy and the Drug Amendments of 1962, Matthew ORAM, 2012

Efficacy and Enlightenment: LSD Psychotherapy and the Drug Amendments of 1962 Matthew ORAM Journal of the History of Medicine and Allied Sciences, 2012, Volume 69, Number 2, 221-250. doi:10.1093/jhmas/jrs050   ABSTRACT. The decline in therapeutic research with lysergic acid diethylamide (LSD) in the United States over the course of the 1960s has commonly been attributed to the growing controversy surrounding its recreational use. However, research difficulties played an equal role in LSD psychotherapy’s demise, as they frustrated researchers’ efforts to clearly establish the efficacy of treatment. Once the Kefauver Harris Drug Amendments of 1962 introduced the requirement that proof of efficacy be established through controlled clinical [...]

Lire la suite

Ibogaine : A Novel Anti-Addictive Compound. A Comprehensive Literature Review, Jonathan Freedlander, 2003

Ibogaine : A Novel Anti-Addictive Compound. A Comprehensive Literature Review Jonathan Freedlander Journal of Drug Education and Awareness, 2003   Introduction and History Ibogaine is a naturally occurring indole alkaloid, found in a variety of African shrubs of the Tabernathe genus (Obach, Pablo, and Mash, 1998). The root of the Tabernanthe iboga plant (also known as eboga) is the most frequently cited source of ibogaine, and this plant contains 11 other known psychoactive constituents (Popik, and Skolnick, 1999). Chemically, ibogaine is classified as a tryptamine, being a rigid analogue of melatonin, and is structurally similar to harmaline, another natural alkaloid and psychedelic (Xu et al, [...]

Lire la suite

The Psychedelic Library – Bibliographie

http://psychedelic-library.org/lsdmenu.htm   Alas! the forbidden fruits were eaten, And thereby the warm life of reason congealed. A grain of wheat eclipsed the sun of Adam, Like as the Dragon's tail dulls the brightness of the moon. — Rumi: Masnavi I Ma'navi   Introductory Papers The Exploration of Experience by: Humphrey Osmond, an excerpt from his 1957 paper "A Review of the Clinical Effects of Psychotomimetic Agents" Psychedelics, Technology, Psychedelics by: Bernard Aaronson and Humphry Osmond, the introductory chapter to PSYCHEDELICS, the Uses and Implications of Hallucinogenic Drugs Psychedelics and the Future by Humphry Osmond and Bernard S. Aaronson Request for a Public Hearing to: The Hearing Clerk, Department of Health, Education and Welfare   Menus Psychotherapy and Psychedelic Drugs Psychedelic Research [...]

Lire la suite

Pharmacology of Consciousness or Pharmacology of Spirituality ? A Historical Review of Psychedelic Clinical Studies, Ismael Apud, 2016

Pharmacology of Consciousness or Pharmacology of Spirituality ? A Historical Review of Psychedelic Clinical Studies Ismael Apud The Journal of Transpersonal Psychology, 2016, Vol. 48, No. 2, 150-167.   ABSTRACT: In the second half of the twentieth century, when psychopharmacology was not developed as we know it today and psychoanalysis was an influential school, various psychiatrists began to develop a ‘pharmacology of consciousness,’ and became interested in hallucinogens as new paths for accessing the unconscious. However, with the psychedelic model, the pharmacology of consciousness turned also into a ‘pharmacology of spirituality,’ focused on the use of spiritual experiences as catalyzers of psychological change. This article [...]

Lire la suite

The Bastiaans Method of Drug-Assisted Therapy A preliminary follow-up study with former clients, Hans Ossebaard & Nicole Maalste, 1999

The Bastiaans Method of Drug-Assisted Therapy A preliminary follow-up study with former clients Hans Ossebaard & Nicole Maalste Bulletin of the Multidisciplinary Association for Psychedelic Studies, MAPS : 1999, Vol 9, N° 2, pp. 3-9 This study was made possible in part by a grant to MAPS from the Promind Foundation The present pilot study is a preliminary investigation among former clients who participated in therapy supervised by Bastiaans and his collaborators (see MAPS Bulletin, VIII (2), p. 3; 1998) and conducted with the help of hallucinogenic drugs. This follow-up study aims to systematically establish the subjective judgements of clients, to work out a profile that [...]

Lire la suite

Neurotoxicity and LSD treatment: a follow-up study of 151 patients in Denmark, Jens Knud Larsen, 2016

Neurotoxicity and LSD treatment : a follow-up study of 151 patients in Denmark Jens Knud Larsen University Hospital of Aarhus, Risskov, Denmark History of Psychiatry, 2016, Vol. 27, (2), 172–189 DOI: 10.1177/0957154X16629902   Abstract LSD was introduced in psychiatry in the 1950s. Between 1960 and 1973, nearly 400 patients were treated with LSD in Denmark. By 1964, one homicide, two suicides and four suicide attempts had been reported. In 1986 the Danish LSD Damages Law was passed after complaints by only one patient. According to the Law, all 154 applicants received financial compensation for LSD-inflicted harm. The Danish State Archives has preserved the case material of 151 [...]

Lire la suite