Étiquette : cannabidiol

Immune Responses Regulated by Cannabidiol, James M. Nichols and Barbara L.F. Kaplan, 2019

Immune Responses Regulated by Cannabidiol James M. Nichols and Barbara L.F. Kaplan Cannabis and Cannabinoid Research, 2019, Volume X, Number X Doi : 10.1089/can.2018.0073   Abstract Introduction : Cannabidiol (CBD) as Epidiolex (GW Pharmaceuticals) was recently approved by the U.S. Food and Drug Administration (FDA) to treat rare forms of epilepsy in patients 2 years of age and older. Together with the increased societal acceptance of recreational cannabis and CBD oil for putative medical use in many states, the exposure to CBD is increasing, even though all of its biological effects are not understood. Once such example is the ability of CBD to be anti-inflammatory and [...]

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Cannabis and Coronavirus : What Cannabis Patients Want to Know, Rxleaf.com, February 17, 2020

Cannabis and Coronavirus : What Cannabis Patients Want to Know Jennifer Grant https://www.rxleaf.com/cannabis-and-coronavirus-what-cannabis-patients-want-to-know/ February 17, 2020 There is evidence that cannabis can reduce viral load in HIV, can it help COVID-19 patients? At the time of writing, there were 69, 287 confirmed cases of the coronavirus and 1670 deaths. With the rapid escalation of the outbreak, these numbers will surely be outdated by the time of publication. With several regions heading into states of emergencies, including quarantine, nervous travelers are looking for anti viral herbs to reduce the chance of infection. Patients have asked us: What about cannabis? There have been rumors about successful treatments for coronavirus, [...]

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Abuse potential assessment of cannabidiol (CBD) in recreational polydrug users : A randomized, double-blind, controlled trial, Kerri A. Schoedel et al., 2018

Abuse potential assessment of cannabidiol (CBD) in recreational polydrug users : A randomized, double-blind, controlled trial Kerri A. Schoedel, Isabella Szeto, Beatrice Setnik, Edward M. Sellers, Naama Levy-Cooperman, Catherine Mills, Tilden Etges, Kenneth Sommerville Epilepsy & Behavior, 2018, 88, 162–171. Doi : 10.1016/j.yebeh.2018.07.027   a b s t r a c t Rationale : Treatment with a highly purified oral solution of cannabidiol (CBD), derived from the plant Cannabis sativa L., demonstrated some evidence of central nervous system (CNS)-related adverse events in patients enrolled in phase 3 trials for treatment of childhood-onset epilepsy. Cannabidiol was categorized as a Schedule 1 substance by the United States Drug [...]

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CANNABIDIOL (CBD), Pre-Review Report, Agenda Item 5.2, Expert Committee on Drug Dependence, WHO, 2017

CANNABIDIOL (CBD), Pre-Review Report, Agenda Item 5.2 Expert Committee on Drug Dependence Thirty-ninth Meeting, Geneva, 6-10 November 2017 39th ECDD (2017) Agenda item 5.2 Cannabidiol (CBD) Contents Acknowledgements .................................................................................................................. 4 Summary ................................................................................................................................... 5 1. Substance identification ........................................................................................................ 6 A. International Nonproprietary Name (INN) .......................................................................... 6 B. Chemical Abstract Service (CAS) Registry Number .............................................................. 6 C. Other Chemical Names .......................................................................................................... 6 D. Trade Names .......................................................................................................................... 6 E. Street Names .......................................................................................................................... 6 F. Physical Appearance .............................................................................................................. 6 G. WHO Review History ............................................................................................................. 6 2. Chemistry ............................................................................................................................... 6 A. Chemical Name ...................................................................................................................... 6 B. Chemical Structure ................................................................................................................. 7 C. Stereoisomers ......................................................................................................................... 7 D. Methods and Ease of Illicit Manufacturing ............................................................................ 7 E. Chemical Properties ............................................................................................................... 9 F. Identification and Analysis ..................................................................................................... 9 3. Ease of [...]

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Cannabidiol for Viral Diseases : Hype or Hope ?, Alex Mabou Tagne et al., 2020

Cannabidiol for Viral Diseases : Hype or Hope ? Alex Mabou Tagne, Barbara Pacchetti, Mikael Sodergren, Marco Cosentino, and Franca Marino Cannabis and Cannabinoid Research, 2020,1-11. Doi : 10.1089/can.2019.0060   Abstract Background : The possibility of cannabidiol (CBD) to be used as an antiviral or to treat viral diseases has received limited attention so far, despite the growing number of claims that CBD could be used for the treatment of viral infection-related conditions. Aim and Methods : Therefore, we systematically retrieved and critically evaluated the scientific literature available on PubMed and the claims on the Internet, to assess the current state of knowledge on the use of [...]

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Anticonvulsive Properties of Cannabidiol in a Model of Generalized Seizure Are Transient Receptor Potential Vanilloid 1 Dependent, Royston A. Gray et al., 2019

Anticonvulsive Properties of Cannabidiol in a Model of Generalized Seizure Are Transient Receptor Potential Vanilloid 1 Dependent Royston A. Gray, Colin G. Stott, Nicholas A. Jones, Vincenzo Di Marzo, and Benjamin J. Whalley Cannabis and Cannabinoid Research, 2019,1-5. Doi : 10.1089/can.2019.0028   Abstract Introduction : Highly purified cannabidiol (CBD) (approved as Epidiolex in the United States) has demonstrated efficacy with an acceptable safety profile in patients with Lennox–Gastaut or Dravet syndrome in four randomized controlled trials. CBD possesses affinity for many target classes with functional effects relevant to the pathophysiology of many disease types, including epilepsy. Although the mechanism of action of CBD underlying the reduction [...]

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Unique treatment potential of cannabidiol for the prevention of relapse to drug use: preclinical proof of principle, Gustavo Gonzalez-Cuevas et al., 2018

Unique treatment potential of cannabidiol for the prevention of relapse to drug use: preclinical proof of principle Gustavo Gonzalez-Cuevas, Remi Martin-Fardon, Tony M. Kerr, David G. Stouffer, Loren H. Parsons, Dana C. Hammell, Stan L. Banks, Audra L. Stinchcomb and Friedbert Weiss Neuropsychopharmacology, 2018, 43, 2036–2045. Doi : 10.1038/s41386-018-0050-8   Cannabidiol (CBD), the major non-psychoactive constituent of Cannabis sativa, has received attention for therapeutic potential in treating neurologic and psychiatric disorders. Recently, CBD has also been explored for potential in treating drug addiction. Substance use disorders are chronically relapsing conditions and relapse risk persists for multiple reasons including craving induced by drug contexts, susceptibility to [...]

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Bibliographie : Cannabidiol (CBD), Docteur Christian SUEUR, GRECC, mars 2020.

Bibliographie : Cannabidiol (CBD) Docteur Christian SUEUR, GRECC, mars 2020.     voir aussi : Bibliographie : Cannabis et Cannabinoïdes en Psychiatrie, Bibliographie : Cannabinoïdes et neuroprotection Bibliographie : Cannabinoïdes et épilepsie Bibliographie : Interactions et antagonisme THC - CBD Bibliographie : Effets indésirables du Cannabis (thérapeutique) sur la Santé mentale Bibliographie : Cannabinoïdes, Dépression et Troubles de l’Humeur Bibliographie : Cannabinoïdes et PTSD Bibliographie : Cannabinoïdes et TSA/TED/psychoses infantiles Bibliographie : Cannabinoïdes et Maladies Neurodégénératives    

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Neuroprotective Effect of Cannabidiol Against Hydrogen Peroxide in Hippocampal Neuron Culture, Jungnam Kim et al. 2020

Neuroprotective Effect of Cannabidiol Against Hydrogen Peroxide in Hippocampal Neuron Culture Jungnam Kim, Ji Yu Choi, Jeongyeon Seo, and Insung S. Choi Cannabis and Cannabinoid Research, 2020,Volume X, Number X, Doi : 10.1089/can.2019.0102   Abstract Introduction: Reports on the neurotoxic and neuroprotective effects of cannabidiol (CBD) have not been in complete accord, showing different and somewhat contradictory results depending upon the brain cell types and experimental conditions employed. This work systematically examines the neuroprotective capability of CBD against oxidative stress (i.e., hydrogen peroxide [H2O2]) as well as its toxicity profile in the in vitro culture platform of primary hippocampal neurons. Materials and Methods: The low cell-density (100 neurons [...]

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Use of Cannabidiol for the Treatment of Anxiety : A Short Synthesis of Pre-Clinical and Clinical Evidence, Madison Wright et al., 2019

Use of Cannabidiol for the Treatment of Anxiety : A Short Synthesis of Pre-Clinical and Clinical Evidence Madison Wright, Patricia Di Ciano, and Bruna Brands Cannabis and Cannabinoid Research, 2019, Volume X, Number X, 1-6. Doi : 10.1089/can.2019.0052   Abstract Anxiety disorders have the highest lifetime prevalence of any mental illness worldwide, leading to high societal costs and economic burden. Current pharmacotherapies for anxiety disorders are associated with adverse effects and low efficacy. Cannabidiol (CBD) is a constituent of the Cannabis plant, which has potential therapeutic properties for various indications. After the recent legalization of cannabis, CBD has drawn increased attention as a potential treatment, as [...]

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