Catégorie : Publications récentes

La folie du Cannabis. Entre non-sens et préjudice, Mischa Hauswirth, 2020, préface Dr Christian Sueur

La folie du Cannabis. Entre non-sens et préjudice, Mischa Hauswirth, Editions Solanacée, 2020, https://edition-solanacee.us7.list-manage.com/track/click?u=84b6c6a0effdaca8f68d4d1e0&id=c04d113cce&e=eaf78900b6   Préface : Dr Christian Sueur, psychiatre, Praticien Hospitalier, président du GRECC.   C’est avec beaucoup d’enthousiasme que j’ai accepté d’écrire une préface pour cet excellent livre de Mischa Hauswirth, qui renouvelle, par sa clarté, sa rigueur, et son « encyclopédisme », l’ouvrage de Lynn Zimmer et John P. Morgan, « Marijuana, mythes et réalités », édité il y a déjà 20 ans (1997 pour l’édition originale, et 2000, pour la traduction française). Comme cet ouvrage « historique », le livre de Mischa Hauswirth rassemble tous les éléments utiles à la compréhension du « phénomène cannabis », tant sur le plan historique [...]

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La lutte contre le trafic de drogue nuit-elle aux politiques de développement ?, Khalid Tinasti, 2021

La lutte contre le trafic de drogue nuit-elle aux politiques de développement ? The Conversation, 28 janvier 2021, 19:07 CET https://theconversation.com/la-lutte-contre-le-trafic-de-drogue-nuit-elle-aux-politiques-de-developpement-152886?utm_medium=email&utm_campaign=La%20lettre%20de%20The%20Conversation%20France%20du%2028%20janvier%202021%20-%201846617981&utm_content=La%20lettre%20de%20The%20Conversation%20France%20du%2028%20janvier%202021%20-%201846617981+CID_eecdec7d9135ee3b7e9772ddf20321f7&utm_source=campaign_monitor_fr&utm_term=La%20lutte%20contre%20le%20trafic%20de%20drogue%20nuit-elle%20aux%20politiques%20de%20dveloppementAuteur Khalid Tinasti Chercheur invité au GSI, et secrétaire exécutif de la Global Commission on Drug Policy, Graduate Institute – Institut de hautes études internationales et du développement (IHEID) Déclaration d’intérêts Khalid Tinasti ne travaille pas, ne conseille pas, ne possède pas de parts, ne reçoit pas de fonds d'une organisation qui pourrait tirer profit de cet article, et n'a déclaré aucune autre affiliation que son organisme de recherche. Partenaires Graduate Institute - Institut de hautes études internationales et du développement (IHEID) apporte un financement [...]

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Positive expectations predict improved mental-health outcomes linked to psychedelic microdosing, L.S. Kaertner et al., 2021

Positive expectations predict improved mental-health outcomes linked to psychedelic microdosing, KAERTNER L.S., STEINBORN M.B., KETTNER H., SPRIGGS M.J., ROSEMAN L., BUCHBORN T., BALAET M., TIMMERMANN C., ERRITZOE D., CARHARDT-HARRIS R.L. : Nature, 2021, 11, 1941 Doi : 1038/s41598-021-81446-7   Abstract Psychedelic microdosing describes the ingestion of near-threshold perceptible doses of classic psychedelic substances. Anecdotal reports and observational studies suggest that microdosing may promote positive mood and well-being, but recent placebo-controlled studies failed to find compelling evidence for this. The present study collected web-based mental health and related data using a prospective (before, during and after) design. Individuals planning a weekly microdosing regimen completed surveys at strategic [...]

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Repeated Ketamine Infusions Linked to Rapid Relief of PTSD, Deborah Brauser, Medscape.com, 2021

Repeated Ketamine Infusions Linked to Rapid Relief of PTSD Deborah Brauser Medscape. com, January 18, 2021 Medscape Medical News © 2021 www.medscape.com/viewarticle/944282_print   Repeated intravenous infusions of ketamine provide rapid relief for patients with posttraumatic stress disorder (PTSD), new research suggests. In what investigators are calling the first randomized controlled trial of repeated ketamine administration for chronic PTSD, 30 patients received six infusions of ketamine or midazolam (used as a psychoactive placebo) over 2 consecutive weeks. Between baseline and week 2, those receiving ketamine showed significantly greater improvement than those receiving midazolam. Total scores on the Clinician-Administered PTSD Scale for DSM-5 (CAPS-5) for the first group were almost 12 points [...]

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Changes in inflammatory biomarkers are related to the antidepressant effects of Ayahuasca, Nicole Leite Galvão-Coelho et al., 2020

Changes in inflammatory biomarkers are related to the antidepressant effects of Ayahuasca Nicole Leite Galvão-Coelho, Ana Cecília de Menezes Galvão, Raíssa Nóbrega de Almeida, Fernanda Palhano-Fontes, Isaac Campos Braga, Bruno Lobão Soares, João Paulo Maia-de-Oliveira, Daniel Perkins, Jerome Sarris and Draulio Barros de Araujo Journal of Psychopharmacology, 2020, 1-9. DOI : 10.1177/0269881120936486   Abstract Background : Ayahuasca is a traditional Amazon brew and its potential antidepressant properties have recently been explored in scientific settings. We conducted a double-blind placebo-controlled trial of ayahuasca with treatment-resistant depression patients (n = 28) and healthy controls (n = 45). Aims : We are evaluating the blood inflammatory biomarkers: C-reactive protein and [...]

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Neuroprotection Following Concussion : The Potential Role for Cannabidiol, Jyotpal Singh, John Patrick Neary, 2020

Neuroprotection Following Concussion : The Potential Role for Cannabidiol Jyotpal Singh, John Patrick Neary Canadian Journal of Neurological Sciences, 2020,  1–12 doi : 10.1017/cjn.2020.23   ABSTRACT : Cannabidiol (CBD) has been generating increasing interest in medicine due to its therapeutic properties and an apparent lack of negative side effects. Research has suggested that high dosages of CBD can be taken acutely and chronically with little to no risk. This review focuses on the neuroprotective effects of a CBD, with an emphasis on its implications for recovering from a mild traumatic brain injury (TBI) or concussion. CBD has been shown to influence the endocannabinoid system, both by [...]

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Reviewing the Potential of Psychedelics for the Treatment of PTSD, Erwin Krediet et al., 2020

Reviewing the Potential of Psychedelics for the Treatment of PTSD Erwin Krediet, Tijmen Bostoen, Joost Breeksema, Annette van Schagen, Torsten Passie, Eric Vermetten International Journal of Neuropsychopharmacology, 2020, 23, (6), 385–400 doi : 10.1093/ijnp/pyaa018 https://pubmed.ncbi.nlm.nih.gov/32170326/   Abstract There are few medications with demonstrated efficacy for the treatment of posttraumatic stress disorder (PTSD). Treatment guidelines have unequivocally designated psychotherapy as a first line treatment for PTSD. Yet, even after psychotherapy, PTSD often remains a chronic illness, with high rates of psychiatric and medical comorbidity. Meanwhile, the search for and development of drugs with new mechanisms of action has stalled. Therefore, there is an urgent need to explore not [...]

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Add-On Cannabidiol Treatment for Drug-Resistant Seizures in Tuberous Sclerosis Complex. A Placebo-Controlled Randomized Clinical Trial, Elizabeth A. Thiele et al., 2020

Add-On Cannabidiol Treatment for Drug-Resistant Seizures in Tuberous Sclerosis Complex. A Placebo-Controlled Randomized Clinical Trial Elizabeth A. Thiele, MD, PhD; E. Martina Bebin, MD, MPA; Hari Bhathal, MD; Floor E. Jansen, MD; Katarzyna Kotulska, MD, PhD; John A. Lawson, BMed, PhD; Finbar J. O'Callaghan, MBChB, PhD; MichaelWong,MD, PhD; Farhad Sahebkar, MD; Daniel Checketts, MSc; Volker Knappertz, MD; for the GWPCARE6 Study Group JAMA Neurology, 2020, December 21 online, E1-E7. doi : 10.1001/jamaneurol.2020.4607   IMPORTANCE : Efficacy of cannabidiol has been demonstrated in seizures associated with Lennox-Gastaut and Dravet syndromes but appears not yet to have been established in conditions with primarily focal seizures, such as [...]

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Cannabis and Cannabinoids: Weighing the Benefits and Risks in Psychiatric Patients, Diana M. Martinez, MD Medscape .com, 2020

Cannabis and Cannabinoids: Weighing the Benefits and Risks in Psychiatric Patients Diana M. Martinez, MD Medscape .com, December 18, 2020 This transcript has been edited for clarity. Hello. I'm Diana Martinez. I'm a psychiatrist at the Columbia University Medical Center in the Department of Psychiatry. Today we'll be talking about the interaction between cannabis and psychiatric disorders. When I say "cannabis," this is really the same as marijuana. I use the term "cannabis" because this is a scientific term for the plant. I'm going to start with a brief history of cannabis. It’s been used for centuries in India as both an intoxicant and a [...]

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Bibliographie : Cannabinoïdes synthétiques et Néocannabinoïdes, Dr Christian Sueur, GRECC, décembre 2020

Bibliographie : Cannabinoïdes synthétiques et Néocannabinoïdes   Dr Christian Sueur, GRECC, décembre 2020   Définitions et Usages des cannabinoïdes synthétiques : 2 - 6 Toxicologie des cannabinoïdes synthétiques : 7– 12 Cannabinoïdes synthétiques et psychose : 11 - 12 Pharmacologie des cannabinoïdes synthétiques : 13 - 16 Neurophysiologie des cannabinoïdes synthétiques : 17 -18 Analyse des cannabinoïdes synthétiques : 18 - 19 Usage médical des cannabinoïdes synthétiques : 20 – 22 Rimonabant : 21 -22  

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