Catégorie : Publications récentes

Cannabis sativa L. and Its Extracts: Regulation of Cannabidiol in the European Union and United Kingdom, Mark J. Tallon, 2020

Cannabis sativa L. and Its Extracts : Regulation of Cannabidiol in the European Union and United Kingdom Mark J. Tallon JOURNAL OF DIETARY SUPPLEMENTS, 2020, VOL. 17, NO. 5, 503–516 Doi : 10.1080/19390211.2020.1795044   ABSTRACT The lawful sale of Cannabis sativa L. and its extracts including Cannabidiol is not harmonized under European Union (EU) law. Such products have in the most part been classified as novel foods and thus illegal for sale in Europe without prior authorization. The regulation of such substances not only spans EU and Member State food laws but also international conventions on illicit drug and psychoactive substances. An understanding of the laws [...]

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Marijuana Use Tied to Repeat MI, Stroke After PCI, Marlene Busko, Medscape Medical News, 2020 

Marijuana Use Tied to Repeat MI, Stroke After PCI Marlene Busko Medscape Medical News, 2020 https://www.medscape.com/viewarticle/941313   Marijuana use was associated with a higher prevalence of recurrent myocardial infarction (MI) and a greater risk of bleeding or stroke after percutaneous coronary intervention (PCI) in separate studies. Rhushik Bhuva, MD, presented the recurrent-MI results from a national US study, and Sang Gune K. Yoo, MD, presented the PCI study, which used data from a Michigan cohort. The studies were presented at the virtual American Heart Association (AHA) Scientific Sessions 2020. Both studies "add to our accumulating knowledge of the cardiovascular risks of marijuana," Ersilia M. DeFilippis, MD, a [...]

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Alerte produit : fleurs séchées de cannabis adultérées aux néocannabinoïdes, Norml, octobre 2020

Alerte produit : fleurs séchées de cannabis adultérées aux néocannabinoïdes. par Le Collectif | Oct 22, 2020 | RDRD, Santé & Prévention | https://www.norml.fr/alerte-produits-neocannabinoides/ Au début du mois de septembre, un signalement nous a été remonté par l’un de nos adhérents sur la circulation sur le marché noir de fleurs séchées de cannabis aux effets indésirables dans la région de Nevers (58). Quelques instants après leur consommation, les usagers ont ressenti des effets indésirables totalement inhabituels comme des picotements sur la langue, des troubles de la vision, des pertes d’équilibre, des vomissements, de la tachycardie voire des sensations d’étouffement. Nous avons alors organisé la [...]

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Circulation d’herbe de cannabis adultérée avec des cannabinoïdes de synthèse, Note SINTES, 2020

Circulation d’herbe de cannabis adultérée avec des cannabinoïdes de synthèse Victor Detrez - Magali Martinez Note SINTES - Octobre 2020, 2 p.   Depuis l’été 2019, plusieurs pays européens ont observé la circulation de résine et d’herbe de cannabis très faiblement dosées en Δ-9-tetrahydrocannabinol (THC), avec ou non du cannabidiol (CBD), adultérées avec des cannabinoïdes de synthèse (Autriche, Suisse)1. Ces produits sont vendus de façon trompeuse comme du simple cannabis. En France, ce phénomène a été rapporte par plusieurs associations (en Provence-Alpes-Côte d’Azur et Bourgogne-Franche-Comte), sans qu’il y ait eu des analyses sur le territoire français jusqu’à maintenant. Ces herbes ou résines ont un [...]

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The experimental effects of psilocybin on symptoms of anxiety and depression : A meta-analysis, Simon B. Goldberg et al, 2020

The experimental effects of psilocybin on symptoms of anxiety and depression : A meta-analysis Simon B. Goldberg, Brian T. Pace, Christopher R. Nicholas, Charles L. Raison, Paul R. Hutson Psychiatry Research, 2020, 284,  112749 Doi : 10.1016/j.psychres.2020.112749   A B S T R A C T The current meta-analysis examined the effects of psilocybin in combination with behavioral interventions on anxiety and depression in samples with elevated symptoms. Across four studies (one uncontrolled; three randomized, placebo-controlled; N = 117), within-group pre-post and pre-follow-up effects on anxiety and depression were large (Hedges’ gs=1.16 to 1.47) and statistically significant. Across three placebo-controlled studies, pre-post placebo-controlled effects were also [...]

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Post-acute psychological effects of classical serotonergic psychedelics : a systematic review and meta-analysis, Simon B. Goldberg et al, 2020,

Post-acute psychological effects of classical serotonergic psychedelics: a systematic review and meta-analysis Simon B. Goldberg, Benjamin Shechet, Christopher R. Nicholas, Chi Wing Ng, Geetanjali Deole, Zhuofan Chen and Charles L. Raison Psychological Medicine, 2020, 1–12. doi : 10.1017/S003329172000389X   Abstract Background. Scientific interest in the therapeutic effects of classical psychedelics has increased in the past two decades. The psychological effects of these substances outside the period of acute intoxication have not been fully characterized. This study aimed to: (1) quantify the effects of psilocybin, ayahuasca, and lysergic acid diethylamide (LSD) on psychological outcomes in the post-acute period; (2) test moderators of these effects; and (3) evaluate [...]

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Access to cannabidiol without a prescription : A cross-country comparison and analysis, Iain S. McGregor et al, 2020

Access to cannabidiol without a prescription : A cross-country comparison and analysis Iain S. McGregor, Elizabeth A. Cairns, Sarah Abelev, Rhys Cohen, Mat Henderson, Daniel Couch, Jonathon C. Arnold, Natalie Gauld International Journal of Drug Policy, 2020, 85, 102935 Doi : 10.1016/j.drugpo.2020.102935   A B S T R A C T Background : Recent legislative change has allowed increased access to cannabis products in many jurisdictions. In some locations, this includes over-the-counter (OTC) and/or online access to products containing cannabidiol (CBD), a non-intoxicating cannabinoid with therapeutic properties. Here we compared the availability of CBD products and the associated legislative and regulatory background in nine selected countries. Methods [...]

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Cannabidiol prescription in clinical practice: an audit on the first 400 patients in New Zealand, Graham Gulbransen et al, 2020

Cannabidiol prescription in clinical practice: an audit on the first 400 patients in New Zealand Graham Gulbransen, MBChB, FAChAM, FRNZCGP1*, William Xu2, Bruce Arroll, MBChB, PhD, FRNZCG BJGP Open, 2020, 1-8 DOI : 10.3399/bjgpopen20X101010   Abstract Background : Cannabidiol (CBD) is the non- euphoriant component of cannabis. In 2017, the New Zealand Misuse of Drugs Regulations (1977) were amended, allowing doctors to prescribe CBD. Therapeutic benefit and tolerability of CBD remains unclear. Aim : To review the changes in self- reported quality of life measurements, drug tolerability, and dose- dependent relationships in patients prescribed CBD oil for various conditions at a single institution. Design & setting : An [...]

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CBD (Cannabidiol) Product Attitudes, Knowledge, and Use Among Young Adults, Meghann Wheelera et al, 2020

CBD (Cannabidiol) Product Attitudes, Knowledge, and Use Among Young Adults Meghann Wheelera, Julie Williams Mertena, Benjamin T Gordonb, and Hanadi Hamadic SUBSTANCE USE & MISUSE, 2020, VOL. 55, NO. 7, 1138–1145 doi : 10.1080/10826084.2020.1729201 ABSTRACT Background : Cannabidiol (CBD), a non-psychoactive component of cannabis is marketed as a potential treatment for many conditions and widely available to purchase as a dietary supplement. In 2017, sales of CBD exceeded 820 million dollars despite many unconfirmed health claims, murky legality, and limited product efficacy and safety testing. Purpose/Objectives : This study aims to explore cannabidiol (CBD) knowledge, attitudes, and use among young adults. Methods : The anonymous 36-item survey [...]

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Development of Ketamine Administration as a Treatment for Chronic PTSD, Abigail B. Collins et al., 2020

Development of Ketamine Administration as a Treatment for Chronic PTSD Abigail B. Collins, BS; Sarah B. Rutter, MA; and Adriana Feder, MD Psychiatric Annals, 2020, 50, (2), 68-76. doi : 10.3928/00485713-20200109-01   ABSTRACT Posttraumatic stress disorder (PTSD) is a highly prevalent, chronic, and dis-abling condition for which currently available pharmacotherapies are insuf-ficiently effective. Ketamine, which is a glutamate N-methyl-D-aspartate (NMDA) receptor antagonist, has emerged as a promising and rapid-act-ing novel treatment intervention for this disorder. Findings from a proof-of-concept, randomized, controlled cross-over study of single-dose intravenous ketamine administration (compared to single-dose midazolam) in patients with chronic PTSD suggest that ketamine is associated with rapid improvement in [...]

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