Catégorie : Essais Cliniques

IACM-Bulletin du 13 Janvier 2020

IACM-Bulletin du 13 Janvier 2020 Italie: Selon la Haute Cour, cultiver de petites quantités de cannabis à la maison n'est pas un crime Science/Homme: L'apport oral de graisse peut augmenter de deux fois la biodisponibilité systémique du THC Science/Homme: L'exercice a réduit le nombre de maux de tête et les niveaux d'anandamide chez les personnes souffrant de migraine Science/Homme: Selon une enquête les patients atteints du syndrome de la Tourette préfèrent le cannabis médical au THC pur et au Sativex En bref Un coup d'œil sur le passé Italie: Selon la [...]

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Drug-drug interactions as a result of coadministering Δ9-THC and CBD with other psychotropic agents, Carola Rong et al., 2018

Drug-drug interactions as a result of coadministering Δ9-THC and CBD with other psychotropic agents Carola Rong, Nicole E. Carmona, Yena L. Lee, Renee-Marie Ragguett, Zihang Pan, Joshua D. Rosenblat, Mehala Subramaniapillai, Margarita Shekotikhina, Fahad Almatham, Asem Alageel, Rodrigo Mansur, Roger C. Ho & Roger S. McIntyre Expert Opinion on Drug Safety, 2018, 17:1, 51-54. Doi : 10.1080/14740338.2017.1397128   ABSTRACT Introduction : To determine, via narrative, non-systematic review of pre-clinical and clinical studies, whether the effect of cannabis on hepatic biotransformation pathways would be predicted to result in clinically significant drug-drug interactions (DDIs) with commonly prescribed psychotropic agents. Areas covered: A non-systematic literature search was conducted using the following [...]

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Patient Experiences of Psilocybin-Assisted Psychotherapy : An Interpretative Phenomenological Analysis, Alexander B. Belser et al., 2017

Patient Experiences of Psilocybin-Assisted Psychotherapy : An Interpretative Phenomenological Analysis Alexander B. Belser, Gabrielle Agin-Liebes, T. Cody Swift, Sara Terrana, Neşe Devenot, Harris L. Friedman, Jeffrey Guss, Anthony Bossis and Stephen Ross Journal of Humanistic Psychology, 2017, 1 –35 Doi : 10.1177/0022167817706884 journals.sagepub.com/home/jhp   Abstract The psychological mechanisms of action involved in psilocybin-assisted psychotherapy are not yet well understood. Despite a resurgence of quantitative research regarding psilocybin, the current study is the first qualitative study of participant experiences in psilocybin-assisted psychotherapy. Semistructured interviews were carried out with 13 adult participants aged 22 to 69 years (M = 50 years) with clinically elevated anxiety associated with a cancer [...]

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Patient-reported use of medical cannabis for pain, anxiety, and depression symptoms : Systematic review and meta-analysis, Jesse D. Kosiba et al., 2019

Patient-reported use of medical cannabis for pain, anxiety, and depression symptoms : Systematic review and meta-analysis Jesse D. Kosiba, Stephen A. Maisto, Joseph W. Ditre Social Science & Medicine, 2019, 181-192. https://doi.org/10.1016/j.socscimed.2019.06.005 This study is the first to conduct a systematic review and meta-analysis of empirical studies that assess patient-reported reasons for using medical cannabis to alleviate pain, anxiety, and depression. The present review further assessed the quality of studies and identified several methodological flaws in extant research. Highlights •Systematically reviewed studies why patients use medical cannabis. •Pain was a common reason for medical cannabis use (64%). •Anxiety (50%) and depression (34%) were [...]

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The Role of Cannabis in Treating Anxiety : An Update, Michael Van Ameringen et al., 2019

The Role of Cannabis in Treating Anxiety : An Update Michael Van Ameringen; Jasmine Zhang; Beth Patterson; Jasmine Turna Current Opinion in Psychiatry, 2019, 33, (1), 1-7. DOI : 10.1097/YCO.0000000000000566 https://www.medscape.com/viewarticle/922111?nlid=133169_425&src=WNL_mdplsfeat_191224_mscpedit_psyc&uac=292598PZ&spon=12&impID=2219742&faf=1 Abstract and Introduction Abstract Purpose of review: Cannabis use for medical purposes has become increasingly common, including as treatment for mental health disorders such as anxiety. Unfortunately, the evidence examining its use in mental health has been slow to evolve, but is emerging. Given the widespread use of cannabis, it is important for both clinicians and those who suffer with anxiety to understand the effects of cannabis on symptoms of anxiety. In this review, we present [...]

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Soigner l’alcoolisme et la dépression avec des psychédéliques ? Entretien avec David Nutt, video, 2019

Soigner l'alcoolisme et la dépression avec des psychédéliques? Entretien avec David Nutt #RTSsanté , 11 avril 2019 https://www.youtube.com/watch?time_continue=55&v=D8QNY2bdNCk&feature=emb_logo Vidéo en complément du reportage « Le retour des psychédéliques » : https://youtu.be/503cSLA0Z38   Parmi les très nombreux articles cosignés par le Professeur David J. NUTT, du Psychedelic Research Group, Department of Medicine, Imperial College London, London, United Kingdom, les références suivantes sont disponibles sur le site du GRECC :   Dissociable effects of cannabis with and without cannabidiol on the human brain’s resting-state functional connectivity, Matthew B. Wall, Rebecca Pope, Tom P. Freeman, Oliwia S. Kowalczyk, Lysia Demetriou, Claire Mokrysz, Chandni Hindocha, Will Lawn, Michael A.P. Bloomfield, Abigail M. [...]

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Real-World Approaches to Cannabinoids in Pediatric-Onset Epilepsy: What Do the Data Tell Us? CME, Anup Patel, WWW.medscape.org, 2019

Real-World Approaches to Cannabinoids in Pediatric-Onset Epilepsy: What Do the Data Tell Us? CME Anup Patel, MD Posted: 12/19/2019 https://www.medscape.org/viewarticle/922715   Educational Impact Challenge The goal of this activity is to improve knowledge and competence related to the selection of cannabinoid-based therapies for pediatric-onset seizure disorders. Before you begin this activity, please assess your clinical knowledge by completing this brief survey. Answering these questions again after the activity will allow you to see what you learned and to compare your answers with those of your peers. What did you learn from this activity? Please click on the "Next" button to proceed to a brief survey to see how your [...]

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Evaluation of the effects of CBD hemp extract on opioid use and quality of life indicators in chronic pain patients : a prospective cohort study, Alex Capano et al., 2019

Evaluation of the effects of CBD hemp extract on opioid use and quality of life indicators in chronic pain patients : a prospective cohort study Alex Capano, Richard Weaver & Elisa Burkman Postgraduate Medicine, 2019, © 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. Doi : 10.1080/00325481.2019.1685298   ABSTRACT Context : Chronic pain is highly prevalent in most of the industrialized nations around the world. Despite the documented adverse effects, opioids are widely used for pain management. Cannabinoids, and specifically Cannabidiol, is proposed as an opioid alternative, having comparable efficacy with better safety profile. Objectives : We aim to investigate the impact [...]

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Myorelaxant Effect of Transdermal Cannabidiol Application in Patients with TMD : A Randomized, Double-Blind Trial, Aleksandra Nitecka-Buchta et al., 2019

Myorelaxant Effect of Transdermal Cannabidiol Application in Patients with TMD : A Randomized, Double-Blind Trial Aleksandra Nitecka-Buchta, Anna Nowak-Wachol, KacperWachol, KarolinaWalczynska-Dragon, Paweł Olczyk, Olgierd Batoryna, Wojciech Kempa and Stefan Baron Journal of Clinical Medicine, 2019, 8, 188, 1-17. doi : 10.3390/jcm8111886 Abstract Background : The healing properties of cannabidiol (CBD) have been known for centuries. In this study, we aimed to evaluate the efficiency of the myorelaxant effect of CBD after the transdermal application in patients with myofascial pain. Methods : The Polish version of the Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD Ia and Ib) was used. A total of 60 patients were enrolled [...]

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Effects of CBD-Enriched Cannabis sativa Extract on Autism Spectrum Disorder Symptoms : An Observational Study of 18 Participants Undergoing Compassionate Use, Paulo Fleury-Teixeira et al., 2019

Effects of CBD-Enriched Cannabis sativa Extract on Autism Spectrum Disorder Symptoms : An Observational Study of 18 Participants Undergoing Compassionate Use Paulo Fleury-Teixeira, Fabio Viegas Caixeta, Leandro Cruz Ramires da Silva, Joaquim Pereira Brasil-Neto and Renato Malcher-Lopes Frontiers in Neurology, October 2019, Volume 10, Article 1145 doi : 10.3389/fneur.2019.01145   Autism Spectrum Disorders comprise conditions that may affect cognitive development, motor skills, social interaction, communication, and behavior. This set of functional deficits often results in lack of independence for the diagnosed individuals, and severe distress for patients, families, and caregivers. There is a mounting body of evidence indicating the effectiveness of pure cannabidiol (CBD) and [...]

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