Étiquette : ethnopharmacologie

Salvia divinorum : from recreational hallucinogenic use to analgesic and anti-inflammatory action, Ulises Coffeen & Francisco Pellicer, 2019

Salvia divinorum : from recreational hallucinogenic use to analgesic and anti-inflammatory action Ulises Coffeen, Francisco Pellicer Journal of Pain Research, 2019, Volume 12, 1069-1076 DOI: 10.2147/JPR.S188619   Abstract : Salvia divinorum is a herbal plant native to the southwest region of Mexico. Traditional preparations of this plant have been used in illness treatments that converge with inflammatory conditions and pain. Currently, S. divinorum extracts have become popular in several countries as a recreational drug due to its hallucinogenic effects. Its main active component is a diterpene named salvinorin A (SA), a potent naturally occurring hallucinogen with a great affinity to the κ opioid receptors and with [...]

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Ibogaine : A review – Chapter 1, Kenneth R. Alper, 2001

Ibogaine : A review - Chapter 1 Kenneth R. Alper The Alkaloids. Chemistry and Biology, 2001, 56,  38 pp DOI: 10.1016/S0099-9598(01)56005-8   I. Introduction, Chemical Properties, and Historical Time Line ..................... A. Introduction................................................................................................... B. Chemical Structure and Properties .............................................................. C. Historical Time Line ..................................................................................... II. Mechanisms of Action .................................................................................. A. Neurotransmitter Activities........................................................................... B. Discrimination Studies.................................................................................. C. Effects on Neuropeptides............................................................................... D. Possible Effects on Neuroadaptations Related to Drug Sensitization or Tolerance ....................................................................................................... III. Evidence of Efficacy in Animal Models........................................................ A. Drug Self-Administration .............................................................................. B. Acute Opioid Withdrawal .............................................................................. C. Conditioned Place Preference........................................................................ D. Locomotor Activity........................................................................................ E. Dopamine Efflux............................................................................................. IV Evidence of Efficacy and Subjective Effects in Humans .............................. A. Evidence of Efficacy........................................................................................ B. Subjective Effects ........................................................................................... V. Pharmacokinetics ........................................................................................... A. Absorption....................................................................................................... B. Distribution .................................................................................................... C. Metabolism .................................................................................................... D. Excretion [...]

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The fourfold discovery of Mescaline (1896–1919), Ivo Gurschler, 2019

The fourfold discovery of Mescaline (1896–1919) Ivo Gurschler Chemical Monthly, 2019, 150, 941–947 © Springer-Verlag GmbH Austria, part of Springer Nature 2019 https://doi.org/10.1007/s00706-019-02444-0 Abstract This is an historical account of the pharmacological, chemical, and anthropological research concerning the molecular makeup of the peyote cactus (Lophophora williamsii) that laid the ground for Ernst Spaeth’s structural elucidation of mescaline as 3,4,5-trimethoxyphenethylamine. Keywords : History of science · Psychedelic studies · Organic chemistry · Alkaloids · Mescaline · Drugs   Introduction The exploration of the constituents of the peyote cactus and its effects upon the human psyche was an interdisciplinary undertaking that defied national borders. The material way to the heart of the [...]

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Ayahuasca Scientific Papers, AEDMP, 2013

Ayahuasca Scientific Papers AEDMP - Asociación para el Estudio y la Divulgación de la Medicina Psicodélica Research conducted by: Genís Oña -2013- Asociación para el Estudio y la Divulgación de la Medicina Psicodélica. Castellarnau, 11 2º 1ª 43004 Tarragona Spain Tel. 675 55 33 44 Email: medicina.psicodelica@hotmail.com www.medicinapsicodelica.org   Content _____________________________________ 1. What is ayahuasca? 2. Scientific papers about ayahuasca arranged chronologically (1969-2013) - G. R. Dolmatoff (1969). El contexto cultural de un alucinógeno aborigen : Banisteriopsis Caapi - C. Grob et al. (1996). Human Psychopharmacology of Hoasca, a Plant Hallucinogen Used in Ritual Context in Brazil - J. C. Callaway et al. (1999). Pharmacokinetics of Hoasca Alkaloids in Healthy Humans - B. Shanon (2000). Ayahuasca and [...]

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The Secret of the Kykeon, Peter Webster

The Secret of the Kykeon Peter Webster The Psychedelic Library   The original hypothesis of The Road to Eleusis suggests that the ergot species Claviceps purpurea, collected by the hierophantic priests from its natural and common parasitisation on barley growing in the Rarian plain adjacent to Eleusis, was the probable active ingredient of the kykeon, the psychoactive potion used in the yearly Rite at Eleusis. It was further suggested that the hierophants would have processed the C. purpurea ergot by dissolving off the water-soluble alkaloids since this fraction contained ergonovine, the principal hypothesised psychoactive compound, a lysergic acid amide very similar in structure to, [...]

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Peyote – Mescaline Scientific Papers, AEDMP – 2014-

Peyote - Mescaline Scientific Papers AEDMP - Asociación para el Estudio y la Divulgación de la Medicina Psicodélica Research conducted by : Juan Spuch & Genís Oña Divulgación de la Medicina Psicodélica. Castellarnau, 11 2º 1ª 43004 Tarragona Spain Tel. 675 55 33 44 Email: medicina.psicodelica@hotmail.com www.medicinapsicodelica.org Content _____________________________________ 1. What is peyote? 2. Scientific papers about peyote - mescaline arranged chronologically (1954-2012) - H. Denber & S. Merlis (1954). A Note on Some Therapeutic Implications of the Mescaline induced State - C. Landis & J. Clausen (1954). Certain Effects of Mescaline and Lysergic Acid on Psychological Functions - J. Cattell (1954). The Influence of Mescaline on Psychodynamic Material - W. Frederking (1955). Intoxicant [...]

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Psilocybin Scientific Papers, AEDMP, 2014

Psilocybin Scientific Papers AEDMP  - Asociación para el Estudio y la Divulgación de la Medicina Psicodélica Research conducted by: Fco. Miguel Ríos & Genís Oña  - 2014 - Asociación para el Estudio y la Divulgación de la Medicina Psicodélica. Castellarnau, 11 2º 1ª 43004 Tarragona Spain Tel. 675 55 33 44 Email: medicina.psicodelica@hotmail.com www.medicinapsicodelica.org   Content _____________________________________ 1.   What is Psilocybin? 2.   Scientific papers about Psilocybin arranged chronologically (1959-2014) -   A. Hofmann (1959). Chemical Aspects of Psilocybin, the Psychotropic Principle from the Mexican Fungus,  Psilocybe Mexicana  Heim  -   S. Malitz et al. (1960). Some Observations on Psilocybin, a New Hallucinogen, in Volunteer Subjects  -   L. E. [...]

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Les Champignons dans la culture. A propos d’un livre de M. R. G. Wasson, Claude Lévi-Strauss, 1970

Les Champignons dans la culture. A propos d'un livre de M. R. G. Wasson Claude Lévi-Strauss L'Homme, 1970, 10-1, pp. 5-16 On sait que les hymnes du RgVeda font une place considérable à une plante enivrante, le Soma, dont le suc exprimé et filtré, puis coupé de lait frais ou caillé, était consommé par les prêtres au cours du rituel et principalement, semble-t-il, par ceux chargés d'incarner le dieu Indra et son cocher Vâyu. Chez les anciens Iraniens, une boisson enivrante, appelée Haoma dans l'Avesta, était sans doute la même chose que le Soma. Depuis le xvme siècle, les [...]

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Le microdosage de substances psychédéliques : bref historique et nouveaux axes de recherche, Vittorio Biancardi,

Le microdosage de substances psychédéliques : bref historique et nouveaux axes de recherche Vittorio Biancardi Revue CIRCE, 2019, 11, 25pp Résumé Le micro-dosage est un phénomène social de plus en plus répandu parmi la communauté des consommateurs et consommatrices des substances dites psychédéliques. Il consiste une consommation d’un dixième de la dose typique de substance (principalement LSD ou Psilocybine) de façon fréquente, deux ou trois fois par semaine, pour améliorer les capacités cognitives ou comme auto-thérapie. L’analyse de ce phénomène est actuellement très fragmentaire et inconsistante, tant du point de vue des sciences humaines que du point de vue des sciences dites «dures». L’objectif [...]

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The Mechanisms of Psychedelic Visionary Experiences : Hypotheses from Evolutionary Psychology, Michael J. Winkelman, 2017

The Mechanisms of Psychedelic Visionary Experiences: Hypotheses from Evolutionary Psychology Michael J. Winkelman Frontiers in Neuroscience, 2017, 11, article 539, 1-17. doi: 10.3389/fnins.2017.00539   Neuropharmacological effects of psychedelics have profound cognitive, emotional, and social effects that inspired the development of cultures and religions worldwide. Findings that psychedelics objectively and reliably produce mystical experiences press the question of the neuropharmacological mechanisms by which these highly significant experiences are produced by exogenous neurotransmitter analogs. Humans have a long evolutionary relationship with psychedelics, a consequence of psychedelics’ selective effects for human cognitive abilities, exemplified in the information rich visionary experiences. Objective evidence that psychedelics produce classicmystical experiences, coupled [...]

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