Clinical and Preclinical Evidence for Functional Interactions of Cannabidiol and Δ9-Tetrahydrocannabinol Douglas L Boggs, Jacques D Nguyen, Daralyn Morgenson, Michael A Taffe and Mohini Ranganathan Neuropsychopharmacology Reviews, 2018, 43, 142–154. doi : 10.1038/npp.2017.209; The plant Cannabis sativa, commonly called cannabis or marijuana, has been used for its psychotropic and mind-altering side effects for millennia. There has been growing attention in recent years on its potential therapeutic efficacy as municipalities and legislative bodies in the United States, Canada, and other countries grapple with enacting policy to facilitate the use of cannabis or its constituents for medical purposes. There are 4550 chemical compounds and 4100 phytocannabinoids [...]
Lire la suiteNeuroprotection Following Concussion : The Potential Role for Cannabidiol Jyotpal Singh, John Patrick Neary Canadian Journal of Neurological Sciences, 2020, 1–12 doi : 10.1017/cjn.2020.23 ABSTRACT : Cannabidiol (CBD) has been generating increasing interest in medicine due to its therapeutic properties and an apparent lack of negative side effects. Research has suggested that high dosages of CBD can be taken acutely and chronically with little to no risk. This review focuses on the neuroprotective effects of a CBD, with an emphasis on its implications for recovering from a mild traumatic brain injury (TBI) or concussion. CBD has been shown to influence the endocannabinoid system, both by [...]
Lire la suiteLa maladie d’Alzheimer et le cannabis médical Kalapa Clinic, Barcelone, Espagne By Alexandra|24,09, 2020 La maladie d’Alzheimer neurodégénérative est la forme la plus courante de démence, qui survient généralement chez les personnes âgées de plus de 65 ans. Environ 24 millions de personnes dans le monde souffrent de cette maladie, qui porte le nom du médecin Alois Alzheimer. Il a décrit la maladie pour la première fois en 1906. La maladie d’Alzheimer : Que se passe-t-il dans le cerveau? Chez les patients atteints de la maladie d’Alzheimer, les cellules nerveuses du cerveau meurent progressivement, ce qui entraîne un rétrécissement du cerveau pouvant aller jusqu’à 20 [...]
Lire la suiteTroubles anxieux : le CBD peut soulager les symptômes Kalapa Clinic, Barcelone, Espagne By Gesa|30/06/2020 La peur est une réaction naturelle à certaines situations et à certains événements. Elle remplit à la fois une fonction d’avertissement et de protection. Lors d’un trouble anxieux, cependant, elle développe une dynamique propre qui est très stressante pour les personnes concernées. Diverses études et rapports d’expérience indiquent que le cannabinoïde non-psychoactif cannabidiol (CBD) peut soulager leurs symptômes. En Allemagne, le trouble anxieux est la maladie mentale la plus courante, devançant même la dépression. Environ 12 millions de personnes sont touchées, les femmes plus souvent que les hommes (1). Le [...]
Lire la suiteCannabinoids and Reproduction : A Lasting and Intriguing History Giovanna Cacciola, Rosanna Chianese, Teresa Chioccarelli, Vincenza Ciaramella, Silvia Fasano, Riccardo Pierantoni, RosariaMeccariello and Gilda Cobellis Pharmaceuticals, 2010, 3, 3275-3323. doi : 10.3390/ph3103275 Abstract : Starting from an historical overview of lasting Cannabis use over the centuries, we will focus on a description of the cannabinergic system, with a comprehensive analysis of chemical and pharmacological properties of endogenous and synthetic cannabimimetic analogues. The metabolic pathways and the signal transduction mechanisms, activated by cannabinoid receptors stimulation, will also be discussed. In particular, we will point out the action of cannabinoids and endocannabinoids on the different neuronal networks [...]
Lire la suiteRole of the endogenous cannabinoid system in nicotine addiction : novel insights Islam Hany Gamaleddin, Jose M.Trigo, Aliou B. Gueye, Alexander Zvonok, Alexandros Makriyannis, Steven R. Goldberg and Bernard Le Foll Frontiers in Psychiatry, 2015, Vol 6, Article 41, 1-12. doi : 10.3389/fpsyt.2015.00041 Several lines of evidence have shown that the endogenous cannabinoids are implicated in several neuropsychiatric diseases. Notably, preclinical and human clinical studies have shown a pivotal role of the cannabinoid system in nicotine addiction. The CB1 receptor inverse agonist/antagonist rimonabant (also known as SR141716)was effective to decrease nicotine-taking and nicotine-seeking in rodents, as well as the elevation of dopamine induced by [...]
Lire la suiteCannabinomimetric Lipids : From Natural Extract to Artificial Synthesis Ya-Ru Gao, Yong-Qiang Wang Natural Products and Bioprospecting, 2018, 8, 1–21 doi : 10.1007/s13659-017-0151-9 Abstract Endocannabinoid system is related with various physiological and cognitive processes including fertility, pregnancy, during pre- and postnatal development, pain-sensation, mood, appetite, and memory. In the latest decades, an important milestone concerning the endocannabinoid system was the discovery of the existence of the cannabinoid receptors CB1 and CB2. Anandamide was the first reported endogenous metabolite, which adjusted the release of some neurotransmitters through binding to the CB1 or CB2 receptors. Then a series of cannabinomimetric lipids were extracted from marine organisms, which [...]
Lire la suiteDans 3 heures, le premier webinaire de la série d'événements gratuits de l'IACM commencera, qui se déroulera jusqu'au 3 décembre 2020. Tous les webinaires peuvent être consultés gratuitement jusqu'au 31 mars 2021. Il n'y a donc aucun problème si vous manquez un rendez-vous. O. k. Vous pouvez copier le Magath ici https://new.cannabis-med.org/e2020 15 octobre 2020, 18 heures (CET) Dr. Roger Pertwee Les utilisations thérapeutiques potentielles de certains cannabinoïdes dérivés du cannabis et synthétiques révélées par leurs propriétés pharmacologiques -- Quels sont les médicaments cannabinoïdes approuvés qui ont déjà été développés ? -- Existe-t-il des cannabinoïdes végétaux (phytocannabinoïdes) ayant des propriétés pharmacologiques, pour lesquels des applications thérapeutiques [...]
Lire la suiteThe role of cannabinoid transmission in emotional memory formation: implications for addiction and schizophrenia Huibing Tan, Tasha Ahmad, Michael Loureiro, Jordan Zunder and Steven R. Laviolette Frontiers in Psychiatry, 2014,Vol 5, Article 73, 1-12 doi : 10.3389/fpsyt.2014.00073 Emerging evidence from both basic and clinical research demonstrates an important role for endo-cannabinoid (ECB) signaling in the processing of emotionally salient information, learning, and memory. Cannabinoid transmission within neural circuits involved in emotional processing has been shown to modulate the acquisition, recall, and extinction of emotionally salient memories and importantly, can strongly modulate the emotional salience of incoming sensory information. Two neural regions in particular, the [...]
Lire la suiteActivation of CB1R Promotes Lipopolysaccharide-Induced IL-10 Secretion by Monocytic Myeloid-Derived Suppressive Cells and Reduces Acute Inflammation and Organ Injury Jérémie Joffre, Che-Chung Yeh, Erika Wong, Mayuri Thete, Fengyun Xu, Ivana Zlatanova, Elliot Lloyd, Lester Kobzik, Matthieu Legrand, and Judith Hellman The Journal of Immunology, 2020, 204: 1–20. doi : 10.4049/jimmunol.2000213 Cannabis sativa and its principal components, D9-tetrahydrocannabinol (D9-THC) and cannabidiol, are increasingly being used to treat a variety of medical problems, including inflammatory conditions. Although studies suggest that the endocannabinoid system has immunomodulatory properties, there remains a paucity of information on the effects of cannabinoids on immunity and on outcomes of infection and injury. [...]
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