Étiquette : hallucinogenes

Acute Effects of Lysergic Acid Diethylamide in Healthy Subjects, Yasmin Schmid et al., 2014,

Acute Effects of Lysergic Acid Diethylamide in Healthy Subjects Yasmin Schmid, Florian Enzler, Peter Gasser, Eric Grouzmann, Katrin H. Preller, Franz X. Vollenweider, Rudolf Brenneisen, Felix Müller, Stefan Borgwardt, and Matthias E. Liechti Biological Psychiatry, 2014, Vol. 78, 8, 544-553 http://dx.doi.org/10.1016/j.biopsych.2014.11.015   ABSTRACT BACKGROUND : After no research in humans for .40 years, there is renewed interest in using lysergic acid diethylamide (LSD) in clinical psychiatric research and practice. There are no modern studies on the subjective and autonomic effects of LSD, and its endocrine effects are unknown. In animals, LSD disrupts prepulse inhibition (PPI) of the acoustic startle response, and patients with schizophrenia exhibit similar [...]

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The “Endless Trip” among the NPS Users : Psychopathology and Psychopharmacology in the Hallucinogen-Persisting Perception Disorder. A Systematic Review, Laura Orsolini et al., 2017

The “Endless Trip” among the NPS Users : Psychopathology and Psychopharmacology in the Hallucinogen-Persisting Perception Disorder. A Systematic Review Laura Orsolini, Gabriele Duccio Papanti, Domenico De Berardis, Amira Guirguis, John Martin Corkery and Fabrizio Schifano Frontiers in Psychiatry, 2017, Vol. 8, article 240 doi: 10.3389/fpsyt.2017.00240   Hallucinogen-persisting perception disorder (HPPD) is a syndrome characterized by prolonged or reoccurring perceptual symptoms, reminiscent of acute hallucinogen effects. HPPD was associated with a broader range of LSD (lysergic acid diethylamide)-like substances, cannabis, methylenedioxy-methamphetamine (MDMA), psilocybin, mescaline, and psychostimulants. The recent emergence of novel psychoactive substances (NPS) posed a critical concern regarding the new onset of psychiatric symptoms/syndromes, including cases [...]

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Salvia divinorum : from recreational hallucinogenic use to analgesic and anti-inflammatory action, Ulises Coffeen & Francisco Pellicer, 2019

Salvia divinorum : from recreational hallucinogenic use to analgesic and anti-inflammatory action Ulises Coffeen, Francisco Pellicer Journal of Pain Research, 2019, Volume 12, 1069-1076 DOI: 10.2147/JPR.S188619   Abstract : Salvia divinorum is a herbal plant native to the southwest region of Mexico. Traditional preparations of this plant have been used in illness treatments that converge with inflammatory conditions and pain. Currently, S. divinorum extracts have become popular in several countries as a recreational drug due to its hallucinogenic effects. Its main active component is a diterpene named salvinorin A (SA), a potent naturally occurring hallucinogen with a great affinity to the κ opioid receptors and with [...]

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Introduction, Psycholytic and Psychedelic Therapy Research 1931-1995, Torsten PASSIE, 1997

Psycholytic and Psychedelic Therapy Research 1931-1995 : Introduction (A Complete International Bibliography) Torsten PASSIE Laurentius Publishers, Hannover, Germany, 1997   1 . INTRODUCTION "The future may teach us to exercise a direct influence, by means of particular chemical substances, on the amounts of energy and their distribution in the mental apparatus. It may be that there are other still undreamt of possibilities of therapy" . Sigmund Freud The present bibliography includes nearly all publications on the psychotherapeutic treatment procedures which are referred to as "psycholytic" or "psychedelic" therapy and their foundations. The methods in question use the psychic activating properties of specific substances to reinforce psychotherapeutic treatments. Some appropriate [...]

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Ayahuasca and Public Health: Health Status, Psychosocial Well-Being, Lifestyle, and Coping Strategies in a Large Sample of Ritual Ayahuasca Users, Genís Ona et al., 2019

Ayahuasca and Public Health : Health Status, Psychosocial Well-Being, Lifestyle, and Coping Strategies in a Large Sample of Ritual Ayahuasca Users Genís Ona, Maja Kohek, Tomàs Massaguer, Alfred Gomariz, Daniel F. Jiménez, Rafael G. Dos Santos, Jaime E. C. Hallak, Miguel Ángel Alcázar- Córcoles & José Carlos Bouso Journal of Psychoactive Drugs, 2019, DOI: 10.1080/02791072.2019.1567961   ABSTRACT Assessing the health status of ayahuasca users has been challenging due to the limitations involved in randomized clinical trials and psychometric approaches. The main objective of this study is the implementation of an approach based on public health indicators. We developed a self-administered questionnaire that was administered to long-term [...]

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Survey study of challenging experiences after ingesting psilocybin mushrooms : Acute and enduring positive and negative consequences, Theresa M. Carbonaro et al., 2016

Survey study of challenging experiences after ingesting psilocybin mushrooms : Acute and enduring positive and negative consequences Theresa M. Carbonaro, Matthew P. Bradstreet, Frederick S. Barrett, Katherine A. MacLean, Robert Jesse, Matthew W. Johnson and Roland R. Griffiths Journal of Psychopharmacology, 2016, 1 –11 DOI: 10.1177/0269881116662634 Abstract Acute and enduring adverse effects of psilocybin have been reported anecdotally, but have not been well characterized. For this study, 1993 individuals (mean age 30 yrs; 78% male) completed an online survey about their single most psychologically difficult or challenging experience (worst “bad trip”) after consuming psilocybin mushrooms. Thirty-nine percent rated it among the top five most challenging [...]

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Psilocybin can occasion mystical-type experiences having substantial and sustained personal meaning and spiritual significance, Roland R. Griffiths et al., 2006

Psilocybin can occasion mystical-type experiences having substantial and sustained personal meaning and spiritual significance Roland R. Griffiths, William A. Richards, Una McCann, Robert Jesse Psychopharmacology, 2006 DOI 10.1007/s00213-006-0457-5   Abstract Rationale : Although psilocybin has been used for centuries for religious purposes, little is known scientifically about its acute and persisting effects. Objectives : This double-blind study evaluated the acute and longer-term psychological effects of a high dose of psilocybin relative to a comparison compound administered under comfortable, supportive conditions. Materials and methods : The participants were hallucinogennaïve adults reporting regular participation in religious or spiritual activities. Two or three sessions were conducted at 2-month intervals. Thirty volunteers [...]

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Mystical experiences occasioned by the hallucinogen psilocybin lead to increases in the personnality domain of openness, Katherine A. MacLean, Matthew W. Johnson and Roland R. Griffiths, 2011

Mystical experiences occasioned by the hallucinogen psilocybin lead to increases in the personnality domain of openness Katherine A. MacLean, Matthew W. Johnson and Roland R. Griffiths Journal of Psychopharmacology, 2011, 25, (11), 1453-1461. doi: 10.1177/0269881111420188.   Abstract A large body of evidence, including longitudinal analyses of personality change, suggests that core personality traits are predominantly stable after age 30. To our knowledge, no study has demonstrated changes in personality in healthy adults after an experimentally manipulated discrete event. Intriguingly, double-blind controlled studies have shown that the classic hallucinogen psilocybin occasions personally and spiritually significant mystical experiences that predict longterm changes in behaviors, attitudes and values. In [...]

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Mystical-type experiences occasioned by psilocybin mediate the attribution of personal meaning and spiritual significance 14 months later, Roland R. Griffiths et al., 2008

Mystical-type experiences occasioned by psilocybin mediate the attribution of personal meaning and spiritual significance 14 months later Roland R. Griffiths ,W.A. Richards , Matthew W. Johnson, Una D. McCann, R. Jesse Journal of Psychopharmacology, 2008, 1–12. Doi : 10.1177/0269881108094300   Abstract Psilocybin has been used for centuries for religious purposes; however, little is known scientifically about its long-term effects. We previously reported the effects of a double-blind study evaluating the psychological effects of a high psilocybin dose. This report presents the 14-month follow-up and examines the relationship of the follow-up results to data obtained at screening and on drug session days. Participants were 36 hallucinogen-naïve adults [...]

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Psilocybin occasioned mystical-type experiences : immediate and persisting dose-related effects, Roland R. Griffiths et al., 2011

Psilocybin occasioned mystical-type experiences : immediate and persisting dose-related effects Roland R. Griffiths, Matthew W. Johnson, William A. Richards, Brian D. Richards, Una McCann, Robert Jesse Psychopharmacology, 2011 DOI 10.1007/s00213-011-2358-5   Abstract Rationale : This dose-effect study extends previous observations showing that psilocybin can occasion mystical-type experiences having persisting positive effects on attitudes, mood, and behavior. Objectives : This double-blind study evaluated psilocybin (0, 5, 10, 20, 30 mg/70 kg, p.o.) administered under supportive conditions. Methods : Participants were 18 adults (17 hallucinogennaïve). Five 8-h sessions were conducted individually for each participant at 1-month intervals. Participants were randomized to receive the four active doses in either ascending or [...]

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