Mois : août 2019

The Relevance of Sex in the Association of Synthetic Cannabinoid Use With Psychosis and Agitation in an Inpatient Population, Anahita Bassir Nia et al., 2019

The Relevance of Sex in the Association of Synthetic Cannabinoid Use With Psychosis and Agitation in an Inpatient Population Anahita Bassir Nia, MD‡; Claire L. Mann, BA; Sharron Spriggs, MA; Daniel R. DeFrancisco, MD; Steven Carbonaro, MD; Lyla Parvez, MA; Igor I. Galynker, MD, PhD; Charles A. Perkel, MD; and Yasmin L. Hurd, PhD Journal of Clinical Psychiatry, 2019, 80, (4), 18m12539 https://doi.org/10.4088/JCP.18m12539 Background : Current evidence suggests that women are more sensitive to the effects of cannabinoids. The aim of this study was to investigate the relevance of sex in the association of synthetic cannabinoid (SC) use with psychosis and agitation. Methods : A [...]

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Multiple receptors contribute to the behavioral effects of indoleamine hallucinogens, Adam L. Halberstadt & Mark A. Geyer, 2011

Multiple receptors contribute to the behavioral effects of indoleamine hallucinogens Adam L. Halberstadt & Mark A. Geyer Neuropharmacology, 2011, 61, (3), 364–381. doi:10.1016/j.neuropharm.2011.01.017.   Abstract Serotonergic hallucinogens produce profound changes in perception, mood, and cognition. These drugs include phenylalkylamines such as mescaline and 2,5-dimethoxy-4-methylamphetamine (DOM), and indoleamines such as (+)-lysergic acid diethylamide (LSD) and psilocybin. Despite their differences in chemical structure, the two classes of hallucinogens produce remarkably similar subjective effects in humans, and induce cross-tolerance. The phenylalkylamine hallucinogens are selective 5-HT2 receptor agonists, whereas the indoleamines are relatively nonselective for serotonin (5-HT) receptors. There is extensive evidence, from both animal and human studies, that the [...]

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Lifetime marijuana use in relation to insulin resistance in lean, overweight, and obese US adults, Gerard Ngueta & Ruth Ndjaboue, 2019

Lifetime marijuana use in relation to insulin resistance in lean, overweight, and obese US adults Gerard Ngueta, Ruth Ndjaboue Journal of Diabetes, 2019 https://doi.org/10.1111/1753-0407.12958 Abstract Background Obese individuals are more likely to show insulin resistance (IR). However, limited population studies on marijuana use with markers of IR have yielded mixed results. The aim of this study was to examine the association of marijuana use with IR in US adults with different body mass index (BMI) status. Methods Data from the 2009 to 2016 National Health and Nutrition Examination Survey (NHANES) were abstracted. Minimal lifetime marijuana use was estimated using the duration of regular exposure and frequency of use. [...]

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Endocannabinoid signaling in psychiatric disorders: a review of positron emission tomography studies, Matthew E. Sloan et al., 2018

Endocannabinoid signaling in psychiatric disorders: a review of positron emission tomography studies Matthew E. Sloan, Caroline W. Grant, Joshua L. Gowin, Vijay A. Ramchandani and Bernard Le Foll Acta Pharmacologica Sinica, 2018, 0, 1–9; https://doi.org/10.1038/s41401-018-0081-z   Endocannabinoid signaling is implicated in an array of psychopathologies ranging from anxiety to psychosis and addiction. In recent years, radiotracers targeting the endocannabinoid system have been used in positron emission tomography (PET) studies to determine whether individuals with psychiatric disorders display altered endocannabinoid signaling. We comprehensively reviewed PET studies examining differences in endocannabinoid signaling between individuals with psychiatric illness and healthy controls. Published studies evaluated individuals with five psychiatric [...]

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Cannabis Withdrawal, Nicolas J. Schlienz and Ryan Vandrey, 2019

Cannabis Withdrawal Nicolas J. Schlienz and Ryan Vandrey I. D. Montoya, S. R. B. Weiss (eds.), Cannabis Use Disorders, https://doi.org/10.1007/978-3-319-90365-1_11   Introduction Drug withdrawal refers to a constellation of symptoms that occur following abrupt cessation of chronic drug use. Though drug withdrawal can occur from stopping use of medication, it is most often encountered within the context of illicit, non-medicinal, drug use. The withdrawal symptoms that emerge following extended and frequent use of abused drugs are a key feature of what define substance use disorders [4, 85]. Further, there is accumulating neurobiological evidence that withdrawal drives the maintenance of problematic substance misuse through a mechanism of [...]

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Case Series: Salvia divinorum as a Potential Addictive Hallucinogen, Joseph El-Khoury & Evelyne Baroud, 2018

Case Series: Salvia divinorum as a Potential Addictive Hallucinogen Joseph El-Khoury, Evelyne Baroud The American Journal on Addictions, 2018, 27, 163–165 DOI: 10.1111/ajad.12715   Background and Objective : Recreational use of Salvia divinorum (salvia), a potent, naturally occurring hallucinogen, is on the rise internationally. Despite the paucity of information about its long term health effects, salvia is readily available and generally portrayed as a safe non-addictive substance. Methods and Results : We report on two patients who presented with an enduring and pervasive pattern of salvia use. Discussion and Conclusions : Evaluating patients for salvia use during clinical assessment is strongly encouraged, especially among young polysubstance users. Scientific [...]

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Flavonoid Derivative of Cannabis Demonstrates Therapeutic Potential in Preclinical Models of Metastatic Pancreatic Cancer, Michele Moreau et al., 2019

Flavonoid Derivative of Cannabis Demonstrates Therapeutic Potential in Preclinical Models of Metastatic Pancreatic Cancer Michele Moreau, Udoka Ibeh, Kaylie Decosmo Noella Bih, Sayeda Yasmin-Karim, Ngeh Toyang, Henry Lowe5 and Wilfred Ngwa Frontiers in Oncology, July 2019, Vol. 9, article 660. doi: 10.3389/fonc.2019.00660   Abstract Pancreatic cancer is particularly refractory to modern therapies, with a 5-year survival rate for patients at a dismal 8%. One of the significant barriers to effective treatment is the immunosuppressive pancreatic tumor microenvironment and development of resistance to treatment. New treatment options to increase both the survival and quality of life of patients are urgently needed. This study reports on a new [...]

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The moderating effect of psychedelics on the prospective relationship between prescription opioid use and suicide risk among marginalized women, Elena Argento et al., 2018

The moderating effect of psychedelics on the prospective relationship between prescription opioid use and suicide risk among marginalized women Elena Argento, Melissa Braschel, Zach Walsh, M. Eugenia Socias and Kate Shannon Journal of Psychopharmacology, 2018, 1–7 DOI : 10.1177/0269881118798610   Abstract Background/aims : Given high rates of depression and suicide among marginalized women, and increasing calls to integrate trauma-informed biomedical and community-led structural interventions, this study longitudinally examines the potential moderating effect of psychedelic use on the relationship between other illicit drug use and suicide risk. Methods : Data (2010–2017) were drawn from a community-based, prospective open cohort of marginalized women in Vancouver, Canada. Extended Cox regression [...]

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Epidemiology of adolescent Salvia divinorum use in Canada, Cheryl L. Currie, 2012

Epidemiology of adolescent Salvia divinorum use in Canada Cheryl L. Currie Drug and Alcohol Dependence, 2012, 128, (1-2) DOI: 10.1016/j.drugalcdep.2012.08.008   a b s t r a c t Background : Salvia divinorum is a potent, naturally occurring hallucinogen gaining popularity as a recreational drug in North America. To date, detailed epidemiologic information about the use of this substance among adolescents living outside the United States has been limited. This study provides information on the prevalence and correlates of Salvia divinorum use among adolesecents in Canada using a nationally representative sample. Methods : Data were obtained from a representative sample of 42,179 Canadian adolescents aged 12–17 years living [...]

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