Étiquette : ayahuasca

Translational evidence for ayahuasca as an antidepressant : what’s next ?

Translational evidence for ayahuasca as an antidepressant : what’s next ? Rafael Guimaraes dos SANTOS, José Carlos BOUSO British Journal of Psychiatry, 2019, 41, (4), 275-276. Doi : 10.1590/1516-4446-2019-4104   Depression is among the most important contributors to global disability and suicidal deaths. Available antidepressants are usually selective inhibitors of serotonin and norepinephrine uptake, which need weeks of daily intake before therapeutic effects appear, have limited efficacy for many patients, and induce significant adverse reactions after prolonged use. Therefore, recent research has focused on finding new antidepressant compounds that are fast-acting, more effective, and less toxic. The article recently published by da Silva et al. in the [...]

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Long-term use of psychedelic drugs is associated with differences in brain structure and personality in humans, José Carlos Bouso et al., 2015

Long-term use of psychedelic drugs is associated with differences in brain structure and personality in humans José Carlos Bouso, FernandaPalhano-Fontes, Antoni Rodríguez-Fornells, Sidarta Ribeiro, Rafael Sanches, José Alexandre S. Crippa, Jaime E.C. Hallak, Draulio B. de Araujo, Jordi Riba European Neuropsychopharmacology, 2015, 25, 483–492 http://dx.doi.org/10.1016/j.euroneuro.2015.01.008 Abstract Psychedelic agents have a long history of use by humans for their capacity to induce profound modifications in perception,emotion and cognitive processes. Despite increasing knowledge of the neural mechanisms involved in the acute effects of these drugs, the impact of sustained psychedelic use on the human brain remains largely unknown. Molecular pharmacology studies have shown that psychedelic 5-hydroxytryptamine (5HT)2A [...]

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Ayahuasca : Psychological and Physiologic Effects, Pharmacology and Potential Uses in Addiction and Mental Illness, Jonathan Hamill et al., 2019

Ayahuasca : Psychological and Physiologic Effects, Pharmacology and Potential Uses in Addiction and Mental Illness Jonathan Hamill, Jaime Hallak, Serdar M. Dursun and Glen Baker Current Neuropharmacology, 2019, 17, 108-128. Doi : 10.2174/1570159X16666180125095902   Abstract Background : Ayahuasca, a traditional Amazonian decoction with psychoactive properties, is made from bark of the Banisteriopsis caapi vine (containing beta-carboline alkaloids) andleaves of the Psychotria viridis bush (supplying the hallucinogen N,N-dimethyltryptamine, DMT). Originally used by indigenous shamans for the purposes of spirit communication, magical experiences, healing, and religious rituals across several South American countries, ayahuasca has been incorporated into folk medicine and spiritual healing, and several Brazilian churches use [...]

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Antidepressive and anxiolytic effects of ayahuasca : a systematic literature review of animal and human studies, Rafael G. dos Santos et al., 2016

Antidepressive and anxiolytic effects of ayahuasca : a systematic literature review of animal and human studies Rafael G. dos Santos, Flavia L. Osorio, José Alexandre S. Crippa, Jaime E.C. Hallak Revista Brasileira de Psiquiatria, 2016, 38, 65–72 doi:10.1590/1516-4446-2015-1701   ABSTRACT Objective : To conduct a systematic literature review of animal and human studies reporting anxiolytic or antidepressive effects of ayahuasca or some of its isolated alkaloids (dimethyltryptamine, harmine, tetrahydroharmine, and harmaline). Methods : Papers published until 3 April 2015 were retrieved from the PubMed, LILACS and SciELO databases following a comprehensive search strategy and using a predetermined set of criteria for article selection. Results : Five hundred and [...]

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The Impact of Ayahuasca on Suicidality : Results From a Randomized Controlled Trial, Richard J. Zeifman et al., 2019

The Impact of Ayahuasca on Suicidality : Results From a Randomized Controlled Trial Richard J. Zeifman, Fernanda Palhano-Fontes, Jaime Hallak, Emerson Arcoverde, João Paulo Maia-Oliveira, Draulio B. Araujo Frontiers in Pharmacology, 2019, Volume 10, Article 1325, 1-10. doi : 10.3389/fphar.2019.01325   Suicide is a major public health problem. Given increasing suicide rates and limitations surrounding current interventions, there is an urgent need for innovative interventions for suicidality. Although ayahuasca has been shown to target mental health concerns associated with suicidality (i.e., depression and hopelessness), research has not yet explored the impact of ayahuasca on suicidality. Therefore, we conducted secondary analyses of a randomized placebo-controlled trial in [...]

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The Therapeutic Potentials of Ayahuasca in the Treatment of Depression, Fernanda Palhano-Fontes et al., 2014

The Therapeutic Potentials of Ayahuasca in the Treatment of Depression Fernanda Palhano-Fontes, Joao C. Alchieri, Joao Paulo M. Oliveira, Bruno Lobao Soares, Jaime E. C. Hallak, Nicole Galvao-Coelho and Draulio B. de Araujo Chapter 2, in B. C. Labate and C. Cavnar (eds.), "The Therapeutic Use of Ayahuasca", Springer-Verlag Berlin Heidelberg, 2014 Doi : 10.1007/978-3-642-40426-9_2,   Abstract Major depressive disorder (MDD) is generally classified as a mood disorder with a profound effect on the individual’s behavior and quality of life. According to the World Health Organization, in about 20 years, depression will be the disorder with the most significant repercussions, both socially and economically. Despite [...]

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Psychedelic Experiential Pharmacology : Pioneering Clinical Explorations with Salvador Roquet (How I Came to All of This : Ketamine, Admixtures and Adjuvants, Don Juan and Carlos Castaneda Too) An Interview with Richard Yensen, Philip E. Wolfson, 2014

Psychedelic Experiential Pharmacology : Pioneering Clinical Explorations with Salvador Roquet (How I Came to All of This : Ketamine, Admixtures and Adjuvants, Don Juan and Carlos Castaneda Too) An Interview with Richard Yensen Philip E. Wolfson International Journal of Transpersonal Studies, 2014, 33, (2), 160-174.   Richard Yensen was a research fellow at the Maryland Psychiatric Research Center from 1972 to 1976. He studied psychedelic psychotherapy with Stanislav Grof, M.D. and other senior staff. During this time he treated patients with substance abuse disorders, cancer, neurosis, and other health professionals seeking a training experience. Dr. Yensen did his Ph.D. dissertation on the use of MDA in [...]

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Drugs, Religion, and Cultural Heritage : An Analysis of the Public Policies Regarding the Use of Ayahuasca in Brazil, Henrique Fernandes Antunes, 2018

Drugs, Religion, and Cultural Heritage : An Analysis of the Public Policies Regarding the Use of Ayahuasca in Brazil Henrique Fernandes Antunes The International Journal of Religion and Spirituality in Society, 2018, Volume #, Issue #, http://doi.org/######################   Abstract : In 1985, ayahuasca was banned for a short period of time by the Federal Council of Drugs (CONFEN). After more than two decades of debates and public policies, the Brazilian government consolidated the regulation of ayahuasca consumption for religious purposes and recognized ayahuasca groups as legitimate religions and part of the cultural heritage of the Amazon region. The aim of this work is to demonstrate that [...]

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Consumption of Ayahuasca by Children and Pregnant Women : Medical Controversies and Religious Perspectives, Beatriz Caiuby Labate, 2011

Consumption of Ayahuasca by Children and Pregnant Women : Medical Controversies and Religious Perspectives Beatriz Caiuby Labate Journal of Psychoactive Drugs, 2011, 43, (1), 27-35. DOI: 10.1080/02791072.2011.566498   Abstract In 2010, the Brazilian Government agency responsible for drug-related issues formulated official Resolutions that categorized the consumption of ayahuasca by pregnant women and children in the Santo Daime and Uniâo do Vegetal ayahuasea-based religions as an "exercise of parental rights." Although ayahuasca groups do enjoy a relative degree of social legitimacy and formal legal recognition in Brazil, the participation of pregnant women and children nevertheless continues to provoke heated discussion. This article raises the main issues involved [...]

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