A Contemporary History of Ibogaine in the United States and Europe THE ALKALOIDS, 2001, Vol.56, Chapitre 14 Copyright © 2001 by Academic Press 0099-9598/01 Kenneth R. Alper, Dana Beal & Charles D. Kaplan I. Introduction In 1995, Dr. Curtis Wright, then the U.S. Food and Drug Administration (FDA) ibogaine project officer, wrote “What’s clear is that a significant portion of the public we serve believes the drug merits investigation” (1). Wright’s statement intimates a relationship of public opinion to regulatory scientific policy. The statement was made at a time when the FDA, partly in response to highly motivated and organized public advocacy, was modifying its drug [...]
Lire la suiteThe alkaloids of Banisteriopsis caapi, the plant source of the Amazonian hallucinogen Ayahuasca, stimulate adult neurogenesis in vitro Jose A. Morales-García, Mario de la Fuente Revenga, Sandra Alonso-Gil, María Isabel Rodríguez-Franco, Amanda Feilding, Ana Perez-Castillo & Jordi Riba Scientific Reports, 2017, 7, 5309 www.nature.com/scientificreports https://www.nature.com/articles/s41598-017-05407-9 DOI:10.1038/s41598-017-05407-9 Abstract : Banisteriopsis caapi is the basic ingredient of ayahuasca, a psychotropic plant tea used in the Amazon for ritual and medicinal purposes, and by interested individuals worldwide. Animal studies and recent clinical research suggests that B. caapi preparations show antidepressant activity, a therapeutic effect that has been linked to hippocampal neurogenesis. Here we report that harmine, tetrahydroharmine and harmaline, the [...]
Lire la suiteAntidepressant Effects of a Single Dose of Ayahuasca in Patients With Recurrent Depression: A SPECT Study. Rafael F. Sanchez, F. de Lima Osorio, R.G. Dos Santos, L.R. Macedo, J.P. Maia-de-Oliveira, L. Wichert-Ana, D.B. de Araujo, J. Riba, J.A. Crippa, J.E. Hallak Journal of Clinical Psychopharmacology, 2016, 36, 1, 77-81. doi: 10.1097/JCP.0000000000000436. PMID : 26650973 Abstract Ayahuasca is an Amazonian botanical hallucinogenic brew which contains dimethyltryptamine, a 5-HT2A receptor agonist, and harmine, a monoamine-oxidase A inhibitor. Our group recently reported that ayahuasca administration was associated with fast-acting antidepressive effects in 6 depressive patients. The objective of the present work was to assess the antidepressive potentials of [...]
Lire la suiteÉtat des lieux de la recherche sur les capacités thérapeutiques des « substances hallucinogènes » au 21e siècle Christian Sueur Psychotropes, 2017/3 (Vol. 23), p. 125-163. DOI 10.3917/psyt.233.0125 https://www.cairn.info/revue-psychotropes-2017-3-page-125.htm Résumé : L’utilisation thérapeutique des substances psychédéliques a été concomitante de la découverte du LSD et de la Mescaline après la Seconde Guerre mondiale. Ces utilisations thérapeutiques concernaient, à l’origine, essentiellement « l’accompagnement » des psychothérapies (thérapies psycholytiques), le traitement des addictions (alcool, puis opiacés) et, du fait de leurs capacités anxiolytiques et antidépressives, la prise en charge des troubles psychologiques post-traumatiques, les dépressions résistantes, les pathologies obsessionnelles et psychosomatiques (douleurs, migraines…) et l’accompagnement des fins [...]
Lire la suiteBIBLIOGRAPHIE : Ayahuasca Neurophysiologie, Pharmacologie, Thérapeutique et Chamanisme Dr Christian Sueur, GRECC, janvier 2020 22 pages 1 - Ayahuasca : généralités : 1 - 5 2 - Neurophysiologie de l’ayahuasca : 6 -8 3 - Pharmacologie de l’ayahuasca : 9 4 - Ayahuasca et Thérapeutique : 12 - 17 5 - Ayahuasca, spiritualité et Chamanisme :18 - 23
Lire la suiteCeremonial ‘Plant Medicine’ use and its relationship to recreational drug use : an exploratory study Caroline Dorsen, Joseph Palamar and Michele G. Shedlin Addiction Research & Theory, 2018 https://doi.org/10.1080/16066359.2018.1455187 ABSTRACT Background : The ceremonial use of psychoactive/hallucinogenic plant based drugs, such as ayahuasca, psilocybin and others, is a growing trend in the United States (US) and globally. To date, there has been little research documenting how many people are using psychoactive substances in this context, who the users are, what benefits/risks exist in the use of these drugs and the relationship between ceremonial drug use and recreational drug use. In this paper we describe a [...]
Lire la suiteCultural Neurophenomenology of Psychedelic Thought: Guiding the “Unconstrained” Mind Through Ritual Context Michael LIFSHITZ, Eli SHEINER, and Laurence J. KIRMAYER The Oxford Handbook of Spontaneous Thought : Mind-Wandering, Creativity, and Dreaming Edited by Kalina Christoff and Kieran C.R. Fox, avril 2018 Abstract : This chapter explores psychedelics as catalysts of spontaneous thought. Classic serotonergic psychedelics such as psilocybin, LSD, and ayahuasca can induce potent alterations in cognition and perception. The chapter reviews research on these substances through the lens of cultural neurophenomenology, which aims to trace how neurobiology and sociocultural factors interact to shape experience. After a decades-long hiatus, the scientific study of psychedelics is rediscovering [...]
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