Le trouble stress post-traumatique et son traitement : au sujet d’une observation. François-Rodolphe INGOLD, GRECC, PARIS Charles D. KAPLAN, UCLA, Los Angeles Christian SUEUR, GRECC, LYON Intervention au Colloque UFCM I-care, Paris, Hôpital de La Salpétrière, 1er juin 2018. AVANT PROPOS La question de ce qu’il est convenu d’appeler le « cannabis thérapeutique », mis à part ses enjeux politico-économiques, est loin de se limiter au cannabis lui-même, en tant que plante et en tant que substances actives. La découverte fondamentale des derniers travaux de recherche ne tient pas à l’identification d’un certain nombre de cannabinoïdes et de terpènes, elle tient à la mise à jour de tout un [...]
Lire la suiteCannabis and the Anxiety of Fragmentation - A Systems Approach for Finding an Anxiolytic Cannabis Chemotype, B. S. Kamal, F. Kamal, D. E. Lantela, Frontiers in Neuroscience, 2018, 12, article 730. https://doi.org/10.3389/fnins.2018.00730 Abstract : Cannabis sativa is a medicinal herb with a diverse range of chemotypes that can exert both anxiolytic and anxiogenic effects on humans. Medical cannabis patients receiving organically grown cannabis from a single source were surveyed about the effectiveness of cannabis for treating anxiety. Patients rated cannabis as highly effective overall for treating anxiety with an average score of 8.03 on a Likert scale of 0 to 10 (0 = not effective, [...]
Lire la suiteThe Endocannabinoid System as A Target for Novel Anxiolytic and Antidepressant Drugs, Chapter 5 S. Gaetani, P. Dipasquale, A. Romano, L. Righetti, T. Cassano, D. Piomelli, V. Cuomo, International Review of Neurobiology, 2009, 85, 57-72 DOI: 10.1016/S0074-7742(09)85005-8 https://www.researchgate.net/publication/26675793_Chapter_5_The_Endocannabinoid_System_as_A_Target_for_Novel_Anxiolytic_and_Antidepressant_Drugs I. The Endogenous Cannabinoid System II. Endocannabinoid Role in Emotional Reactivity and Mood Tone III. EVects of Exogenously Administered Cannabinoid Agonists and Antagonists IV. Enhancement of the Endogenous Cannabinoid Tone V. Faah-Knockout Phenotype VI. Conclusions References Observational studies in humans suggest that exposure to marijuana and other cannabis-derived drugs produces a wide range of subjective eVects on mood tone and emotionality. These observations have their counterpart in animal studies, showing that cannabinoid agonists strongly [...]
Lire la suiteThe endocannabinoid system as a target for novel anxiolytic drugs S. Patel, M.N. Hill, J.F. Cheer, C.T. Wotjak, A. Holmes, Neuroscience and Biobehavioral Reviews, 2017, 76, 56-66. https://doi.org/10.1016/j.neubiorev.2016.12.033 Abstract The endocannabinoid (eCB) system has attracted attention for its role in various behavioral and brain functions, and as a therapeutic target in neuropsychiatric disease states, including anxiety disorders and other conditions resulting from dysfunctional responses to stress. In this mini-review, we highlight components of the eCB system that offer potential ‘druggable’ targets for new anxiolytic medications, emphasizing some of the less well-discussed options. We discuss how selectively amplifying eCBs recruitment by interfering with eCB-degradation, via fatty [...]
Lire la suitehttps://www.ncbi.nlm.nih.gov/books/NBK425767/ The Health Effects of Cannabis and Cannabinoids The Current State of Evidence and Recommendations for Research National Academies of Sciences, Engineering, and Medicine; Health and Medicine Division; Board on Population Health and Public Health Practice; Committee on the Health Effects of Marijuana: An Evidence Review and Research Agenda. Washington (DC): National Academies Press (US); 2017 Jan 12. ISBN-13: 978-0-309-45304-2ISBN-10: 0-309-45304-6 Copyright and Permissions Hardcopy Version at National Academies Press Significant changes have taken place in the policy landscape surrounding cannabis legalization, production, and use. During the past 20 years, 25 states and the District of Columbia have legalized cannabis and/or cannabidiol (a component of cannabis) for [...]
Lire la suitehttps://www.canada.ca/fr/sante-canada/services/drogues-medicaments/cannabis/renseignements-medecins/renseignements-destines-professionnels-sante-cannabis-cannabinoides.html Renseignements destinés aux professionnels de la santé : Le cannabis (marijuana, marihuana) et les cannabinoïdes (Version PDF - 2,690 Ko) Plante séchée ou fraîche et huile destinées à l'administration par ingestion ou par d'autres moyens Agent psychoactif Le présent document a été préparé par la Direction générale de la légalisation et réglementation du cannabis de Santé Canada pour fournir des renseignements sur l'usage du cannabis (marihuana) et des cannabinoïdes à des fins médicales. Le présent document est un résumé d'articles scientifiques examinés par les pairs et de revues internationales sur les utilisations thérapeutiques possibles et sur les effets néfastes du cannabis et des [...]
Lire la suite