Étiquette : analyses

An Analysis of Over-the-Counter Cannabidiol Products in the United Kingdom, Jonathan Paul Liebling et al., 2020

An Analysis of Over-the-Counter Cannabidiol Products in the United Kingdom Jonathan Paul Liebling, Nicholas James Clarkson, Blair William Gibbs, Andrew Stephen Yates, and Saoirse Elizabeth O’Sullivan Cannabis and Cannabinoid Research, 2020, 1-7. DOI: 10.1089/can.2019.0078   Abstract Introduction : Over-the-counter cannabidiol (CBD) products have seen unprecedented recent growth in the United Kingdom. However, analysis of these predominantly unregulated products from other countries tells us that they are often mislabeled or contain unlabeled and potentially dangerous chemicals. Thus, the aim of the present study was to analyze CBD oils available in the United Kingdom. Materials and Methods: Phytocannabinoids, residual solvent, and heavy metals were measured blinded in 29 [...]

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Cannabis : From Cultivar to Chemovar II—A Metabolomics. Approach to Cannabis Classification, Arno Hazekamp et al, 2016,

Cannabis : From Cultivar to Chemovar II—A Metabolomics. Approach to Cannabis Classification Arno Hazekamp, Katerina Tejkalova, and Stelios Papadimitriou Cannabis and Cannabinoid Research, 2016, Volume 1, (1) Doi : 10.1089/can.2016.0017 Abstract Introduction : There is a large disparity between the ‘‘cultural’’ language used by patients using cannabis for selfmedication and the ‘‘chemical’’ language applied by scientists to get a deeper understanding of cannabis effects in laboratory and clinical studies. The distinction between Sativa and Indica types of cannabis, and the different biological effects associated with them, is a major example of this. Despite the widespread use of cannabis by selfmedicating patients, scientific studies are yet [...]

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Do medical cannabis growers attempt to produce cannabis with different cannabinoid concentrations than recreational growers?, Sharon R. Sznitman et al., 2019,

Do medical cannabis growers attempt to produce cannabis with different cannabinoid concentrations than recreational growers? Sharon R. Sznitman, Monica J. Barratt, Tom Decorte, Pekka Hakkarainen, Simon Lenton, Gary Potter, Bernd Werse and Chris Wilkins Drugs and Alcohol Today, 2019, 19, (4), 251-256, Doi : 10.1108/DAT-06-2019-0021   Abstract Purpose – It is conceivable that cannabis cultivators who grow for medical purposes aim to improve the therapeutic index of their cannabis by attempting to produce particular concentrations of CBD and/or THC. The purpose of this paper is to examine whether small-scalemedical cannabis growers differ fromthose growing for recreational reasons in terms of self-assessed concentrations of THC and CBD [...]

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Developing Robust Standardised Analytical Procedures for Cannabinoid Quantification : Laying the Foundations for an Emerging Cannabis-Based Pharmaceutical Industry, Matthew T. Welling et al., 2019

Developing Robust Standardised Analytical Procedures for Cannabinoid Quantification : Laying the Foundations for an Emerging Cannabis-Based Pharmaceutical Industry Matthew T. Welling, Lei Liu, Arno Hazekamp, Ashley Dowell, Graham J. King Medical Cannabis & Cannabinoids, 2019, 2, 1–13 Doi : 10.1159/000496868   Abstract The plant genus Cannabis is a prolific producer of unique pharmaceutically relevant metabolites, commonly referred to as cannabinoids. Robust and standardised methods for the quantification of cannabinoids within botanical and drug forms is a critical step forward for an emerging Cannabis- based pharmaceutical industry, which is poised for rapid expansion. Despite a growing body of analytical methods for the quantification of cannabinoids, few have [...]

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L’huile de chanvre contient-elle du THC et du CBD ?, Newsweed, 11 février 2020, Aurélien BERNARD

L’huile de chanvre contient-elle du THC et du CBD ? Newsweed, 11 février 2020 Aurélien BERNARD https://www.newsweed.fr/huile-chanvre-contient-thc-cbd/   L’huile de chanvre, extraite des graines, est une source précieuse d’omega 3 et 6 et de nutriments dans l’alimentation quotidienne. Sa valeur nutritionnelle et thérapeutique pourrait néanmoins aussi être attribuée à sa composition en cannabinoïdes qui, si faiblement présents, existent quand même. Dans une étude de 2019, plusieurs cannabinoïdes ont été détectés dans l’huile de graines de chanvre et permettent de déterminer des différences dans leur composition chimique. Bien que le CBDA et le CBD soient prédominants dans les dix huiles étudiées, 20 autres cannabinoïdes «mineurs» ont été [...]

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Comprehensive classification of USA cannabis samples based on chemical profiles of major cannabinoids and terpenoids, Ramia Z. Al Bakain et al., 2019

Comprehensive classification of USA cannabis samples based on chemical profiles of major cannabinoids and terpenoids Ramia Z. Al Bakain, Yahya S. Al-Degs, James V. Cizdziel and Mahmoud A. Elsohly Journal of Liquid Chromatography & Related Technologies, 2019 Doi : 10.1080/10826076.2019.1701015   ABSTRACT Different USA-origin cannabis samples were analyzed by GC-FID to quantify all possible cannabinoids and terpenoids prior to their clustering. Chromatographic analysis confirmed the presence of seven cannabinoids and sixteen terpenoids with variable levels. Among tested cannabinoids, D9-Tetrahydro-cannabinol D9-THC and cannabinol CBN were available in excess amounts (1.2–8.0 wt%) and (0.22–1.1 wt%), respectively. Fenchol was the most abundant terpenoid with a range of (0.03–1.0 wt%). [...]

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Isolation and Pharmacological Evaluation of Minor Cannabinoids from High-Potency Cannabis sativa, Mohamed M. Radwan et al., 2015

Isolation and Pharmacological Evaluation of Minor Cannabinoids from High-Potency Cannabis sativa Mohamed M. Radwan, Mahmoud A. ElSohly, Abir T. El-Alfy, Safwat A. Ahmed, Desmond Slade, Afeef S. Husni, Susan P. Manly, Lisa Wilson, Suzanne Seale, Stephen J. Cutler, and Samir A. Ross Journal of Natural Products, 2015 June 26, 78, (6), 1271–1276. doi : 10.1021/acs.jnatprod.5b00065   Abstract Seven new naturally occurring hydroxylated cannabinoids (1–7), along with the known cannabiripsol (8), have been isolated from the aerial parts of high-potency Cannabis sativa. The structures of the new compounds were determined by 1D and 2D NMR spectroscopic analysis, GC-MS, and HRESIMS as 8α hydroxy-Δ9-tetrahydrocannabinol (1), 8β-hydroxy-Δ9-tetrahydrocannabinol (2), 10α-hydroxy-Δ8 [...]

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Characterising heterogeneity in the use of different cannabis products : latent class analysis with 55 000 people who use cannabis and associations with severity of cannabis dependence, Sam Craft et al., 2019

Characterising heterogeneity in the use of different cannabis products : latent class analysis with 55 000 people who use cannabis and associations with severity of cannabis dependence Sam Craft, Adam Winstock, Jason Ferris, Clare Mackie, Michael T. Lynskey and Tom P. Freeman Psychological Medicine, 2019, 1–10. doi : 10.1017/S0033291719002460   Abstract Background. As new cannabis products and administration methods proliferate, patterns of use are becoming increasingly heterogeneous. However, few studies have explored different profiles of cannabis use and their association with problematic use. Methods. Latent class analysis (LCA) was used to identify subgroups of past-year cannabis users endorsing distinct patterns of use from a large international sample [...]

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A Physician’s Guide to the Cannabidiol Craze, Angela Coombs & Diana M. Martinez, 2013

COMMENTARY A Physician's Guide to the Cannabidiol Craze Angela Coombs, MD; Diana M. Martinez, MD Medscape, May 31, 2019 Last month at the Columbia University Department of Psychiatry in upper Manhattan, Columbia chief psychiatry resident Dr Angela Coombs interviewed addiction expert Dr Diana Martinez on a number of issues related to the rising popularity and usage of cannabidiol (CBD). This transcript has been edited for clarity.   Angela Coombs, MD: Hi. My name is Dr Angela Coombs and I'm a chief resident here at Columbia. We are so happy to be able to have Dr Diana Martinez, who's a professor in psychiatry at Columbia and an expert [...]

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A reliable and validated LC-MS/MS method for the simultaneous quantification of 4 cannabinoids in 40 consumer products, Qingfang Meng et al., 2018

A reliable and validated LC-MS/MS method for the simultaneous quantification of 4 cannabinoids in 40 consumer products Qingfang Meng, Beth Buchanan, Jonathan Zuccolo, Mathieu-Marc Poulin, Joseph Gabriele, David Charles Baranowski PLoS ONE, 2018, 13, (5), e0196396. https://doi.org/10.1371/journal.pone.0196396   Abstract In the past 50 years, Cannabis sativa (C. sativa) has gone from a substance essentially prohibited worldwide to one that is gaining acceptance both culturally and legally in many countries for medicinal and recreational use. As additional jurisdictions legalize Cannabis products and the variety and complexity of these products surpass the classical dried plant material, appropriate methods for measuring the biologically active constituents is paramount to ensure [...]

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