What Is the CBD Dosing Required for Effective Pain Relief ? Medscape, 14/12/2018

What Is the CBD Dosing Required for Effective Pain Relief ?

Damian McNamara, CME, Laurie Barclay, MD

Posted: 12/14/2018

Clinical Context

The effects of cannabis in humans include euphoria, increased sensitivity to external experience, relaxation, and potential for addiction. Cannabidiol is a compound in the cannabis plant that lacks euphoric and addictive qualities and that may be useful to treat conditions including chronic pain, nausea, epilepsy, psychosis, and anxiety. The optimal therapeutic dose of CBD has not yet been determined, and it has been used in a wide dose range from 2.85 to 50 mg/kg/day.

The therapeutic effects of CBD appear to emanate from its interaction with the serotonin (5-HT) 1A receptor, but its effects on 5-HT neuronal activity and in models of neuropathic pain were previously unknown. The goals of this study by De Gregorio and colleagues were to explore the effects of acute CBD administration on modulation of dorsal raphe nucleus (DRN) 5-HT neuronal activity in naive animals and to evaluate the effect of repeated low-dose CBD treatment on mechanical allodynia, anxiety-like behaviors, and DRN 5-HT neuronal activity in the spared nerve injury model of neuropathic pain in rats.