The Rapid Rise in Investment in Psychedelics— Cart Before the Horse

The Rapid Rise in Investment in Psychedelics— Cart Before the Horse

Joshua PHELPS, Ravi N. SHAH, Jeffrey A. LIEBERMAN,

JAMA Psychiatry, 2022, 79, (3), 189-190.

Doi : 10.1001/jamapsychiatry.2021.3972


Anticipating a renaissance, many psychedelic medicine companies have conducted initial public offerings, where in private companies first issue news hares of stock for sale to the public, making the companies publicly traded entities.1 As of this writing, there are more than 50 publicly traded companies related to the development or administration of psychedelic like drugs in the US, with at least 3 valued at more than $1 billion. The market for psychedelic substances is projected to grow from $2 billion in 2020 to $10.75 billion by 2027, a growth rate that may even outpace the legal US cannabis market.2
In the Table, we summarize the largest publicly traded psychedelic companies, all of which filed their initial public offerings in 2020or 2021.4,5 In this Viewpoint, we examined key issues to better understand whether this wave of industry-sponsored drug development is being conducted in a manner that can reliably assess the effectiveness of psychedelic drugs.

How Did We Get Here ?

The resurgence of interest in psychedelic medicine has been fueled by the popular desire for access and by commercial investment in the hope that psychedelics will be the next blockbuster class of medications. This trend has extended to policy and legislation. Efforts to decriminalizepsychedelic
substances at the local levelhave succeeded in Denver, Colorado;Washington, DC;Oakland,
California; and other locations. Oregon passed legislation that legalizes access to psilocybin for mental health treatment despite insufficient evidence to support this practice.These regulatory changesmay adversely affect the quality and rigor of biomedical research that are usually associated with the development of a new class of drugs.

Several factors attest to this concern. To our knowledge, there is very little research in psychedelics supported by the National Institutes of Mental Health (NIMH) or major pharmaceutical or biotechnology companies, and the pharmaceutical industry has, in many cases, been decreasing or even withdrawing funding from psychotropic research in recent years.6 At the same time, interest has been spurred by an expanding body of research demonstrating promising results for psychedelicl ike
drugs in a range of conditions, including end of-life anxiety, treatment-refractory depression, posttraumatic stress disorder, and substance use disorder.7 In 2018, the US Food and Drug Administration designated psilocybin a breakthrough therapy, after which the pharmaceutical company COMPASS Pathways PLC began phase 2B clinical trials evaluating use of the substance for treatment-refractory depression.8 This commercial momentum, coupled with the lack of activity on the part of established pharmaceutical firms, created a gap in the market now eagerly being filled by a cadre
of entrepreneurs promising new, effective treatments for an array of mental health concerns.

Reliance on Intellectual Property

For-profit psychedelic companies are under pressure to generate large financial returns to their investors, and the most straightforward path to doing so is by obtaining patents for unique substances or delivery systems. Psilocybin, mescaline, and dimethyltryptamine are all naturally occurring compounds; therefore, they cannot be patented. To generate patents, these firms strive to generate a unique angle in their treatment paradigm, such as a unique indication, delivery platform (eg, sublingual, aerosolized, oral dissolving tablet), proprietary synthetic compound (eg, COMP360, COMPASS Pathway’s proprietary psilocybin), or combination drug (eg, Mind Medicine Inc’s 3,4-methylenedioxymethamphetamine [MDMA]–lysergic acid diethylamide [LSD] combination medication). This approach will help for profit
companies satisfy investors, but it will simultaneously limit the generalizability of any clinical outcomes

The Role of Academic Medical Centers

As the activities undertaken by these companies expand, we must acknowledge that their influence will only increase. These companies are so large that they are funding their own research, which is often conducted at academic medical centers. This is effectively a new iteration of industry-sponsored research, which could introduce bias at the earliest stages of study development, including even influencing the questions that are asked and answered in a given trial.

That said, academic medical centers are not in a position to conduct fully independent research. Funding
from private foundations is orders ofmagnitude less than that available for this sort of industry sponsored research. For example, the Johns Hopkins Center forPsychedelic and Consciousness Researchwas started with roughly $17 million in private funding, whereas the market cap for ATAI Life Sciences is currently around $1.9 billion.3

These effects have been exacerbated by the lack of investment in this area on the part of the NIMH, and
the NIMH has not proactively initiated the research needed to establish the requisite body of knowledge
regarding the mechanisms of action and clinical effectiveness of this unique and potentially valuable class of drugs. This contrasts with the extensive research conducted on cannabis and the numerous ketamine studies sponsored by leading federal agencies, including the NIMH.



Although popular excitement, policy momentum, and financial investment in psychedelics continue to increase, it is imperative that research maintains scientific rigor and dispassion to outcomes in the
pursuitofimprovedtherapeuticsandnewinsightsintothemind,brain, and consciousness that this class of moleculesmaywell afford in the coming years. The presence of large-scale, newly established public
companies as an unprecedented category of stakeholder may help to further understanding of these molecules and their possible clinical applications, but these firms also have a unique set of self-interests
that must be understood and considered. Research enabled by these firms must still meet the same rigorous standards that are expected elsewhere, even if breakthrough status iswarranted.

There may be tension between avid advocates of this class of compounds and the deliberately slower pace of adoption encouraged by the scientific method, but rigorous research is necessary to more fully understand the risks and benefits involved in any presumptive clinical application. The first wave of psychedelic research was disrupted by conflict between cultural and political forces. The current wave of psychedelic research could be susceptible to an emerging conflict between entrepreneurial enthusiasm and scientific deliberation.