Auteur/autrice : GRECC

DOPAMINE – Culture, Drogues et Société, #04 – Avril 2019

DOPAMINE - Culture, Drogues et Société, #04 - Avril 2019 DOPAMINE est une revue numérique mensuelle, tout public, dont les articles sont disponibles en continu sur le site. La plupart sont réservés aux abonnés qui reçoivent tous les mois la revue au format PDF. Cette parution s’adresse à tous ceux qui veulent satisfaire leur curiosité et approfondir leurs connaissances, leur regard et réflexion sur la thématique des drogues et addictions, et leurs représentations. DOPAMINE présente, chronique et décrypte un ensemble de références piochées dans l'actualité culturelle : essais, romans, récits de vie, films, séries, vidéos, revues, enquêtes, rapport ou autres documents... [...]

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Descriptive Psychopathology of the Acute Effects of Intravenous Delta-9-Tetrahydrocannabinol Administration in Humans, Marco Colizzi et al., 2019

Descriptive Psychopathology of the Acute Effects of Intravenous Delta-9-Tetrahydrocannabinol Administration in Humans Marco Colizzi, NathalieWeltens, Philip McGuire, Lukas Van Oudenhove and Sagnik Bhattacharyya Brain Sciences, 2019, 9, 93 doi:10.3390/brainsci9040093 Abstract : Background : Cannabis use can increase the risk of psychosis, and the acute administration of its key psychoactive ingredient, delta-9-tetrahydrocannabinol (D9-THC), can induce transient psychotomimetic symptoms. Methods: A double-blind, randomized, placebo-controlled crossover design was used to investigate the symptomatic eects of acute intravenous administration of D9-THC (1.19 mg/2 mL) in 16 healthy participants (seven males) with modest previous cannabis exposure. Results : In the 20 min following acute D9-THC administration, symptomatic eects of at [...]

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The effects of cannabidiol on impulsivity and memory during abstinence in cigarette dependent smokers, C. Hindocha et al., 2018

The effects of cannabidiol on impulsivity and memory during abstinence in cigarette dependent smokers C. Hindocha, T. P. Freeman, M. Grabski, H. Crudgington, A. C. Davies, J. B. Stroud, R. K. Das, W. Lawn, C. J. A. Morgan & H. V. Curran Scientific Reports, 2018, 8, 7568 DOI:10.1038/s41598-018-25846-2 Abstract : Acute nicotine abstinence in cigarette smokers results in deficits in performance on specific cognitive processes, including working memory and impulsivity which are important in relapse. Cannabidiol (CBD), the non-intoxicating cannabinoid found in cannabis, has shown pro-cognitive effects and preliminary evidence has indicated it can reduce the number of cigarettes smoked in dependent smokers. However, the effects [...]

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Les Nouveaux Produits de Synthèse : Essayer la régulation des usages…, Pierre Chappard et Martine Lacoste,

Supplément Technique : Les Nouveaux Produits de Synthèse Essayer la régulation des usages…. L’arrivée des produits que l’on appelle les « Research Chemicals » ou « legal high » n’est pas un hasard. Elle correspond à une évolution de la société addictogène qui se décline sur plusieurs éléments : - Une nouvelle génération s’est emparée de l’outil Internet et passe énormément de temps « online », dans le monde de la « toile » où continue de s’exprimer une quête de plaisir. Cette nouvelle génération d'usagers partage ses expériences d'usage de NPS à travers des forums internet d'auto-support et acquiert une réelle expertise. - [...]

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Clinical Endocannabinoid Deficiency Reconsidered: Current Research Supports the Theory in Migraine, Fibromyalgia, Irritable Bowel, and Other Treatment-Resistant Syndromes, Ethan B. Russo, 2016

Clinical Endocannabinoid Deficiency Reconsidered: Current Research Supports the Theory in Migraine, Fibromyalgia, Irritable Bowel, and Other Treatment-Resistant Syndromes Ethan B. Russo Cannabis and Cannabinoid Research, 2016, 1, 1, 154-165. DOI: 10.1089/can.2016.0009   Abstract : Medicine continues to struggle in its approaches to numerous common subjective pain syndromes that lack objective signs and remain treatment resistant. Foremost among these are migraine, fibromyalgia, and irritable bowel syndrome, disorders that may overlap in their affected populations and whose sufferers have all endured the stigma of a psychosomatic label, as well as the failure of endless pharmacotherapeutic interventions with substandard benefit. The commonality in symptomatology in these conditions displaying hyperalgesia [...]

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The Cannabis sativa Versus Cannabis indica Debate : An Interview with Ethan Russo, Daniele Piomelli , 2015

The Cannabis sativa Versus Cannabis indica Debate : An Interview with Ethan Russo Daniele Piomelli and Ethan B. Russo Cannabis and Cannabinoid Research, 2016, 1, 1, 44-46 https://doi.org/10.1089/can.2015.29003.ebr   Dr. Ethan Russo, MD, is a board-certified neurologist, psychopharmacology researcher, and Medical Director of PHYTECS, a biotechnology company researching and developing innovative approaches targeting the human endocannabinoid system. Previously, from 2003 to 2014, he served as Senior Medical Advisor and study physician to GW Pharmaceuticals for three Phase III clinical trials of Sativex for alleviation of cancer pain unresponsive to optimized opioid treatment and studies of Epidiolex for intractable epilepsy. He has held faculty appointments in [...]

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Cannabis Roots: A Traditional Therapy with Future Potential for Treating Inflammation and Pain, Natasha R. Ryz et al., 2017

Cannabis Roots: A Traditional Therapy with Future Potential for Treating Inflammation and Pain Natasha R. Ryz, David J. Remillard, Ethan B. Russo Cannabis and Cannabinoid Research, 2017, 2, 1, ReviewOpen Access https://doi.org/10.1089/can.2017.0028 Abstract Introduction: The roots of the cannabis plant have a long history of medical use stretching back millennia. However, the therapeutic potential of cannabis roots has been largely ignored in modern times. Discussion: In the first century, Pliny the Elder described in Natural Histories that a decoction of the root in water could be used to relieve stiffness in the joints, gout, and related conditions. By the 17th century, various herbalists were recommending cannabis root [...]

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The Use of Cannabis for Headache Disorders, Bryson C. Lochte et al., 2017

The Use of Cannabis for Headache Disorders Bryson C. Lochte, Alexandre Beletsky, Nebiyou K. Samuel, Igor Grant Cannabis and Cannabinoid Research, 2017, Vol. 2, No 1., 61-71   https://doi.org/10.1089/can.2016.0033 Abstract Headache disorders are common, debilitating, and, in many cases, inadequately managed by existing treatments. Although clinical trials of cannabis for neuropathic pain have shown promising results, there has been limited research on its use, specifically for headache disorders. This review considers historical prescription practices, summarizes the existing reports on the use of cannabis for headache, and examines the preclinical literature exploring the role of exogenous and endogenous cannabinoids to alter headache pathophysiology. Currently, there is not [...]

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New Therapy for Treatment-Resistant Depression, Feyza Sancar, JAMA, 2019,

New Therapy for Treatment-Resistant Depression Feyza Sancar JAMA, 2019, 321, 15, 1449. doi:10.1001/jama.2019.3596 https://jamanetwork.com/journals/jama/fullarticle/2730598   The FDA has approved esketamine nasal spray as an adjunctive therapy for adults with treatment-resistant depression (TRD), which affects approximately 30% of patients with major depressivedisorder. It’s the first regulatory approval of esketamine, the s-enantiomer of ketamine, for any psychiatric condition worldwide. “There has been a long-standing need for additional effective treatments for treatment resistant depression, a serious and lifethreateningcondition,” Tiffany Farchione,MD, acting director of the FDA’s Division of Psychiatry Products, said in a statement. Marketed as Spravato, the drug is indicated for patients whose depressive symptoms haven’t improved [...]

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Dossier : le Cannabis et la vision, Le Cannabiste.com, 2018

Dossier : le Cannabis et la vision Le Cannabiste.com https://lecannabiste.com/dossier-le-cannabis-et-la-vision/ 4 juillet 2018 jean-pierre Si vous posez la question à des utilisateurs réguliers de Cannabis, la plupart vous répondra que l’usage de cette plante constitue pour eux une source de confort et de bien-être. Pour autant nous savons tous que l’usage du Cannabis n’est pas sans incidence sur le corps humain. Les implications du Cannabis sur l’organisme sont nombreuses et parfois plus complexes qu’il n’y paraît. Dans cet article nous nous allons nous intéresser de plus près à l’état des connaissances et aux événements marquants qui ont émaillé la recherche dans le domaine si particulier, [...]

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