Cannabis and the developing brain : Insights from behavior Viviana Trezza, Vincenzo Cuomo, Louk J.M.J. Vanderschuren European Journal of Pharmacology, 2008, 585, 441-452. Doi : 10.1016/j.ejphar.2008.01.058 A B S T R A C T The isolation and identification, in 1964, of delta-9-tetrahydrocannabinol (THC), the primary psycho-active compound in cannabis, opened the door to a whole new field of medical research. The exploration of the therapeutic potential of THC and other natural and synthetic cannabinoid compounds was paralleled by the discovery of the endocannabinoid system, comprising cannabinoid receptors and their endogenous ligands, which offered exciting new insights into brain function. Besides its well-known involvement in specific [...]
Lire la suiteDevelopmental consequences of perinatal cannabis exposure : behavioral and neuroendocrine effects in adult rodents Patrizia Campolongo, Viviana Trezza, Patrizia Ratano, Maura Palmery & Vincenzo Cuomo Psychopharmacology, 2011, 214, 5–15 Doi : 10.1007/s00213-010-1892-x Abstract Rationale : Cannabis is the most commonly used illicit drug among pregnant women. Since the endocannabinoid system plays a crucial role in brain development, maternal exposure to cannabis derivatives might result in longlasting neurobehavioral abnormalities in the exposed offspring. It is difficult to detect these effects, and their underlying neurobiological mechanisms, in clinical cohorts, because of their intrinsic methodological and interpretative issues. Objectives : The present paper reviews relevant rodent studies examining the [...]
Lire la suiteMalades de Parkinson à Marseille, ils vont tester le cannabis thérapeutique La Provence, 24/1/2020 https://www.laprovence.com/article/societe/5858706/avant-premiere-malades-de-parkinson-a-marseille-ils-vont-tester-le-cannabis-therapeutique.html transmis par principesactifs.fr La prise de cannabis peut-elle soulager certains symptômes moteurs et non-moteurs de la maladie de Parkinson ? "Nous avons de bonnes raisons de le penser mais nous avons besoin de données robustes pour le démontrer", sourit le Pr Olivier Blin, chef du service de pharmacologie clinique de la Timone, à Marseille. Grâce au soutien du centre d’excellence Dhune et de l’association France-Parkinson, son équipe, avec le service de neurologie et de pathologie du mouvement, le CNRS et l’Institut de neurosciences du CHU s’apprêtent à tester la prise de [...]
Lire la suiteAn ontology of psychedelic entity experiences in evolutionary psychology and neurophenomenology Michael James WINKELMAN Journal of Psychedelic Studies, 2018. Doi : 10.1556/2054.2018.002 Background and aims : Psychedelic entity experiences are examined from perspectives of evolutionary psychology and neurophenomenology. Their similarities with other entity experiences illustrate the need for a general biological explanation of entity experiences. Mechanisms are proposed to involve innate modules, operators, and intelligences that underlie ordinary cognitive inferences and provide the basis for supernatural thought. Methods : Comparisons of ayahuasca and dimethyltryptamine (DMT) entity experiences with other types of entity experiences show their fundamental similarities to conceptions of spirit guides, mythological beings, divinities, [...]
Lire la suitePsychedelics in History and World Religions, Editorial Michael James Winkelman Journal of Psychedelic Studies, 2019, 3, (2), pp. 41–42 Doi : 10.1556/2054.2019.021 Recent research has given new hope that psychedelics might provide important tools for treating some of our more intractable ailments. Assessment of the therapeutic applications of psychedelics for various conditions (Winkelman & Sessa, 2019) offers tantalizing promises of what may be seen as miracle cures for their immediate results and effectiveness. As new technologies expand our understandings of the effects of these substances, we are entering a new epoch of understanding the systemic effects of psychedelics on the brain. These findings regarding the [...]
Lire la suiteTherapeutic Applications of Ayahuasca and Other Sacred Medicines Michael J. Winkelman chapter 1, in B. Caiuby Labate and C. Cavnar (eds.) : "The Therapeutic Use of Ayahuasca", Springer-Verlag Berlin Heidelberg 2014 Doi : 10.1007/978-3-642-40426-9_1 Abstract : Therapeutic applications of the psychedelics or hallucinogens found cross-culturally involve treatment of a variety of physical, psychological, and social maladies. Modern medicine has similarly found that a range of conditions may be successfully treated with these agents. The ability to treat a wide variety of conditions derives from variation in active ingredients, doses and modes of application, and factors of set and setting manipulated in ritual. Similarities in effects reported [...]
Lire la suiteTherapeutic Bases of Psychedelic Medicines : Psycho-integrative Effects Michael J. WINKELMAN chapter 1, in "PSYCHEDELIC MEDICINE: SOCIAL, CLINICAL, AND LEGAL PERSPECTIVES" january 2007, pp 1-19. INTRODUCTION For thousands of years, human beings have used medicinal plants to enhance their health and well-being. In cultures around the world, plants commonly referred to as psychedelic, hallucinogens, and entheogens have played central roles in their healing practices. These vision-inducing plants have also played important roles in the religious and spiritual practices of many societies, evoking powerful emotional, cognitive, and therapeutic reactions. These plants that were central to concepts of health, spirituality, and well-being were, however, demonized and rejected [...]
Lire la suiteA novel phytocannabinoid isolated from Cannabis sativa L. with an in vivo cannabimimetic activity higher than Δ9-tetrahydrocannabinol : Δ9-Tetrahydrocannabiphorol Cinzia Citti, Pasquale Linciano, Fabiana Russo, Livio Luongo, Monica Iannotta, Sabatino Maione, Aldo Laganà, Anna Laura Capriotti, Flavio Forni, Maria Angela Vandelli, Giuseppe Gigli & Giuseppe Cannazza Scientific Reports, 2019, 9, 20335 doi : 10.1038/s41598-019-56785-1 2 (-)-Trans-Δ9-tetrahydrocannabinol (Δ9-THC) is the main compound responsible for the intoxicant activity of Cannabis sativa L. The length of the side alkyl chain influences the biological activity of this cannabinoid. In particular, synthetic analogues of Δ9-THC with a longer side chain have shown cannabimimetic properties far higher than Δ9-THC itself. [...]
Lire la suiteBibliographie Cannabinoïdes et Opiacés Dr Christian Sueur, GRECC, janvier 2020.
Lire la suiteHenri Michaux et les gouffres (à propos de l’expérience mescalinienne) François Emmanuel « Moi n’est jamais que provisoire » (Plume). « J’écris pour me parcourir… » annonçait Henri Michaux. À l’hiver 1954 (il a cinquante-cinq ans) il a amplement parcouru le monde, descendu en pirogue un affluent de l’Amazone, promené son étrangeté en Inde, en Chine, en Malaisie…, ramené de ces pays lointains des notations buissonnières, éparses, décalées, des fables drolatiques. Çà et là il s’est fait entomologiste fantasque ou zoologiste d’animaux fantastiques. Toujours curieux de l’ailleurs mais toujours un peu déçu, il a délaissé ces contrées réelles pour d’autres imaginaires, s’est lancé [...]
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