Année : 2020

COVID-19 and Substance Use Disorders: Recommendations to a Comprehensive Healthcare Response, Ali Farhoudian et al., 2020

COVID-19 and Substance Use Disorders: Recommendations to a Comprehensive Healthcare Response Ali Farhoudian, Alexander Baldacchino, Nicolas Clark, Gilberto Gerra, Hamed Ekhtiari, Geert Dom, Azarakhsh Mokri, Mandana Sadeghi, Pardis Nematollahi,  Maryanne Demasi, Christian G. Schütz, Seyed Mohammadreza Hashemian, Payam Tabarsi, Susanna Galea-singer, Giuseppe Carrà, Thomas Clausen, Christos Kouimtsidis, Serenella Tolomeo, Seyed Ramin Radfar, Emran Mohammad Razaghi An International Society of Addiction Medicine (ISAM) Practice and Policy Interest Group Position Paper 29 mars 2020   Abstract : Coronavirus disease 2019 (COVID-19) is escalating across the world with higher morbidities and mortalities in certain vulnerable populations. People who use drugs (PWUD) are a marginalized and stigmatized group with [...]

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Short- and Long-Term Effects of Cannabis on Headache and Migraine, Carrie Cuttler et al., 2019

Short- and Long-Term Effects of Cannabis on Headache and Migraine Carrie Cuttler, Alexander Spradlin, Michael J. Cleveland, and Rebecca M. Craft Journal of Pain, 2019. doi : 10.1016/j.jpain.2019.11.001   Highlights  Headache and migraine ratings were reduced by nearly 50% after using cannabis  Men reported larger reductions in headache after cannabis use than women  Cannabis concentrates were related to larger reductions in headache than flower  Evidence for tolerance to effects of cannabis on headache and migraine was detected  Evidence for medication overuse headache was not detected   Abstract Use of cannabis to alleviate headache and migraine is relatively common, yet research on its effectiveness remains sparse. We sought to [...]

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Cannabidiol regulates behavioural alterations and gene expression changes induced by spontaneous cannabinoid withdrawal, Francisco Navarrete et al., 2018

Cannabidiol regulates behavioural alterations and gene expression changes induced by spontaneous cannabinoid withdrawal Francisco Navarrete, Auxiliadora Aracil-Fernández and Jorge Manzanares British Journal of Pharmacology, 2018. Doi : 10.1111/bph.14226   BACKGROUND AND PURPOSE Cannabidiol (CBD) represents a promising therapeutic tool for treating cannabis use disorder (CUD). This study aimed to evaluate the effects of CBD on the behavioural and gene expression alterations induced by spontaneous cannabinoid withdrawal. EXPERIMENTAL APPROACH Spontaneous cannabinoid withdrawal was evaluated 12 h after cessation of CP-55,940 treatment (0.5 mg·kg1 every 12 h, i.p.; 7 days) in C57BL/6J mice. The effects of CBD (5, 10 and 20 mg·kg1, i.p.) on withdrawal-related behavioural signs were evaluated by [...]

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Cannabis is Not a Suitable Human Coronavirus Treatment, Marc Moulin, Rxleaf.com, 2020

Cannabis is Not a Suitable Human Coronavirus Treatment Marc Moulin March 20, 2020 https://www.rxleaf.com/cannabis-not-good-human-coronavirus-treatment/ Using cannabis as a human coronavirus treatment may make symptoms worse.  Cannabis is great for a lot of things. For example, many physical conditions see symptom abatement with cannabinoid treatment. Additionally, there is adequate, and in some cases, strong, scientific evidence to support consuming cannabis for therapeutic relief. Unfortunately, fighting off influenza-like viruses is not one of them. It’s important to note that there is absolutely no evidence to suggest that cannabis is an effective human coronavirus treatment. On the contrary, researchers from Michigan State University provide recent evidence to demonstrate potentially harmful [...]

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Addiction au cannabis, confinement et détention, Jean Michel Delile et al., Fédération Addiction, mars 2020

Addiction au cannabis, confinement et détention Jean Michel Delile, David Saint Vincent, Laurent Michel, Patrick Veteau Fédération Addiction, mars 2020 Cannabis et dépendance Longtemps, beaucoup ont pensé que le cannabis n’était pas une drogue (dangereuse), ou alors seulement une drogue « douce », au sens où il n’entrainait pas de syndrome physique de manque, à la différence de l’alcool, des opiacés ou des benzodiazépines… Il a fallu beaucoup de temps aux usagers et aux médecins pour réaliser que l’évidence de la souffrance des patients démontrait que la clef de l’addiction en tant que trouble était plus dans le désir/besoin irrépressible de consommer que dans [...]

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Immune Responses Regulated by Cannabidiol, James M. Nichols and Barbara L.F. Kaplan, 2019

Immune Responses Regulated by Cannabidiol James M. Nichols and Barbara L.F. Kaplan Cannabis and Cannabinoid Research, 2019, Volume X, Number X Doi : 10.1089/can.2018.0073   Abstract Introduction : Cannabidiol (CBD) as Epidiolex (GW Pharmaceuticals) was recently approved by the U.S. Food and Drug Administration (FDA) to treat rare forms of epilepsy in patients 2 years of age and older. Together with the increased societal acceptance of recreational cannabis and CBD oil for putative medical use in many states, the exposure to CBD is increasing, even though all of its biological effects are not understood. Once such example is the ability of CBD to be anti-inflammatory and [...]

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LSD Increases Primary Process Thinking via Serotonin 2A Receptor Activation, Rainer Kraehenmann et al., 2017

LSD Increases Primary Process Thinking via Serotonin 2A Receptor Activation Rainer Kraehenmann, Dan Pokorny, Helena Aicher, Katrin H. Preller, Thomas Pokorny, Oliver G. Bosch, Erich Seifritz and Franz X. Vollenweider Frontiers in Pharmacology, 2017, Volume 8, Article 814, 1-9. Doi : 10.3389/fphar.2017.00814   Rationale : Stimulation of serotonin 2A (5-HT2A) receptors by lysergic acid diethylamide (LSD) and related compounds such as psilocybin has previously been shown to increase primary process thinking – an ontologically and evolutionary early, implicit, associative, and automatic mode of thinking which is typically occurring during altered states of consciousness such as dreaming. However, it is still largely unknown whether LSD induces [...]

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MDMA-Induced Dissociative State not Mediated by the 5-HT2A Receptor, Drew J. Puxty et al., 2017

MDMA-Induced Dissociative State not Mediated by the 5-HT2A Receptor Drew J. Puxty, Johannes G. Ramaekers, Rafael de la Torre, Magí Farré, Neus Pizarro, Mitona Pujadas and Kim P. C. Kuypers Frontiers in Pharmacology, 2017, Volume 8, Article 455 Doi : 10.3389/fphar.2017.00455   Previous research has shown that a single dose of MDMA induce a dissociative state, by elevating feelings of depersonalization and derealization. Typically, it is assumed that action on the 5-HT2A receptor is the mechanism underlying these psychedelic experiences. In addition, other studies have shown associations between dissociative states and biological parameters (heart rate, cortisol), which are elevated by MDMA. In order to investigate [...]

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Cannabis and Coronavirus : What Cannabis Patients Want to Know, Rxleaf.com, February 17, 2020

Cannabis and Coronavirus : What Cannabis Patients Want to Know Jennifer Grant https://www.rxleaf.com/cannabis-and-coronavirus-what-cannabis-patients-want-to-know/ February 17, 2020 There is evidence that cannabis can reduce viral load in HIV, can it help COVID-19 patients? At the time of writing, there were 69, 287 confirmed cases of the coronavirus and 1670 deaths. With the rapid escalation of the outbreak, these numbers will surely be outdated by the time of publication. With several regions heading into states of emergencies, including quarantine, nervous travelers are looking for anti viral herbs to reduce the chance of infection. Patients have asked us: What about cannabis? There have been rumors about successful treatments for coronavirus, [...]

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Drogue : touché par le virus, le trafic en pleine mutation, Emmanuel Fansten et Charles Delouche, Libération, 26 mars 2020 à 19:56

Drogue : touché par le virus, le trafic en pleine mutation Par Emmanuel Fansten et Charles Delouche — 26 mars 2020 à 19:56 Libération, 26 mars 2020 à 19:56 https://www.liberation.fr/france/2020/03/26/drogue-touche-par-le-virus-le-trafic-en-pleine-mutation_1783229?xtor=EREC-25&actId=ebwp0YMB8s1_OGEGSsDRkNUcvuQDVN7a57ET3fWtrS8ltxjKGe9elSCGoITXqyaf&actCampaignType=CAMPAIGN_MAIL&actSource=501802 Malgré la pénurie qui guette avec le confinement, les dealers s’adaptent pour poursuivre leur activité : offres sur le Darknet, livraisons via des plateformes d’appels… Et profitent de la saturation des services de police et de justice, débordés par les affaires prioritaires. Drogue : touché par le virus, le trafic en pleine mutation En bordure du périphérique parisien, les allées du marché aux puces de Saint-Ouen, en Seine-Saint-Denis, sont quasi désertes mardi après-midi, une semaine [...]

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