Étiquette : toxicité

Neuroprotective Effect of Cannabidiol Against Hydrogen Peroxide in Hippocampal Neuron Culture, Jungnam Kim et al. 2020

Neuroprotective Effect of Cannabidiol Against Hydrogen Peroxide in Hippocampal Neuron Culture Jungnam Kim, Ji Yu Choi, Jeongyeon Seo, and Insung S. Choi Cannabis and Cannabinoid Research, 2020,Volume X, Number X, Doi : 10.1089/can.2019.0102   Abstract Introduction: Reports on the neurotoxic and neuroprotective effects of cannabidiol (CBD) have not been in complete accord, showing different and somewhat contradictory results depending upon the brain cell types and experimental conditions employed. This work systematically examines the neuroprotective capability of CBD against oxidative stress (i.e., hydrogen peroxide [H2O2]) as well as its toxicity profile in the in vitro culture platform of primary hippocampal neurons. Materials and Methods: The low cell-density (100 neurons [...]

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Harmful Effects of Smoking Cannabis : A Cerebrovascular and Neurological Perspective, Sabrina Rahman Archie et al., 2019

Harmful Effects of Smoking Cannabis : A Cerebrovascular and Neurological Perspective Sabrina Rahman Archie and Luca Cucullo Frontiers in Pharmacology, 2019, 10, Article 1481. doi : 10.3389/fphar.2019.01481   Apart from being used as a medicine, cannabis or marijuana is the most widely abused recreational drug all over the world. The legalization and decriminalization of cannabis in Canada and various states of USA may be the underlying reason of the widespread popularity of it among young population. Various studies have reported about the relationship between cannabis use and different detrimental effects like cardiovascular, cerebrovascular, and neurological complications among different age groups. Specifically, the young population is [...]

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Neurocognitive Consequences of Chronic CannabisUse : A Systematic Review and Meta-Analysis, Pedro Rafael Figueiredo et al., 2019

Neurocognitive Consequences of Chronic CannabisUse : A Systematic Review and Meta-Analysis Pedro Rafael Figueiredo, Serenella Tolomeo, J. Douglas Steele, Alexander Baldacchino Neuroscience and Biobehavioral Reviews, 2019 Doi : 10.1016/j.neubiorev.2019.10.014   "Une méta-analyse échoue à mettre en évidence une "toxicité" de l'usage du cannabis à long terme, sur les fonctions neuropsychologiques cognitives"   Highlights  A meta-analysis was conducted to assess the neuropsychological impact of cannabis.  A limited association was found between chronic cannabis use and neurocognitive deficits.  Memory and chronic cannabis smoking were linked. ABSTRACT Cannabis is currently the most used illicit substance in the world with a global widespread distribution. Although its acute neurocognitive effects on human behaviour have [...]

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Clinical and Toxicological Profile of NBOMes : A Systematic Review, Nino Cesar Marchi et al., 2019

Clinical and Toxicological Profile of NBOMes : A Systematic Review Nino Cesar Marchi, Juliana Nichterwitz Scherer, Letícia Schwanck Fara, Lysa Remy, Rafaela Ornel, Monique Reis, Amanda Zamboni, Mariana Paim, Taís Regina Fiorentin, Carlos Alberto Yasin Wayhs, Lisia Von Diemen, Flavio Pechansky, Felix Henrique Paim Kessler, Renata Pereira Limberger Psychosomatics, 2019 Mar - Apr, 60, (2), 129-138. doi : 10.1016/j.psym.2018.11.002   Background : NBOMes are a new class of potent hallucinogens widely present in illicit drugs. Little is known about this class of drugs, regarding its detection and clinical manifestations of intoxication. Objective : This study aims to enhance care involving NBOMes by reviewing the literature on their [...]

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Que (Devrait-on) Savoir sur la Pharmacologie du Cannabidiol ?, Addictovigilance, 2020

Que (Devrait-on) Savoir sur la Pharmacologie du Cannabidiol ? Article rédigé par les Centres d’Addictovigilance de Grenoble, Marseille, Paris Addictovigilance, Bulletin de l’Association des Centres d’Addictovigilance, 2020, 13. www.addictovigilance.fr Messages clefs Les phyto-cannabinoïdes et les cannabinoïdes de synthèse ont des effets très variés,utiles à caractériser d’un point devue pharmacologique pour mieux préciser les effets de chacun et leurs éventuelles interactions chez l’Homme, a fortiori dans un contexte de large diffusion. Le cannabidiol (CBD) est l’un des principaux phyto-cannabinoïdes présent dans Cannabis sativa, avec le tétrahydrocannabinol (THC). Le CBD a une action pléiotropique notamment sur les récepteurs à la sérotonine, à la dopamine et pas ou très peu [...]

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Interaction of maternal choline levels and prenatal Marijuana’s effects on the offspring, Camille Hoffman et al., 2019

Interaction of maternal choline levels and prenatal Marijuana's effects on the offspring Camille Hoffman, Sharon K. Hunter, Angelo D'Alessandro, KathleenNoonan et al. Psychological Medicine, 2019 Doi : https://doi.org/10.1017/S003329171900179X Published online by Cambridge University Press: 31 July 2019 Abstract Background : This study investigated whether higher maternal choline levels mitigate effects of marijuana on fetal brain development. Choline transported into the amniotic fluid from the mother activates α7-nicotinic acetylcholine receptors on fetal cerebro-cortical inhibitory neurons, whose development is impeded by cannabis blockade of their cannabinoid-1(CB1) receptors. Methods : Marijuana use was assessed during pregnancy from women who later brought their newborns for study. Mothers were informed about [...]

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Stroke in young cannabis users (18-49 years) : National trends in hospitalizations and outcomes, Rupak Desai et al., 2019

Stroke in young cannabis users (18-49 years) : National trends in hospitalizations and outcomes Rupak Desai, Sandeep Singh, Krupa Patel, Hemant Goyal, Manan Shah, Zeeshan Mansuri, Smit Patel, Zabeen K Mahuwala, Larry B Goldstein and Adnan I Qureshi International Journal of Stroke, 2019, doi: 10.1177/1747493019895651 Abstract BACKGROUND : Recent legalization of therapeutic and recreational cannabis use makes it imperative to have an insight into odds and trends in young-onset stroke-related hospitalizations among cannabis users (18-49 years). METHODS : The National Inpatient Sample dataset (2007-2014) was utilized to assess national trends, odds of young-onset stroke-related hospitalizations, and outcomes among cannabis users vs. nonusers using provided discharge weights, [...]

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No Link Between Marijuana Use and Cancer, Except TGCT, Nick Mulcahy, 2019

No Link Between Marijuana Use and Cancer, Except TGCT Nick Mulcahy Medscape Psychiatry, November 27, 2019 https://www.medscape.com/viewarticle/921889?nlid=132907_2052&src=WNL_mdplsnews_191206_mscpedit_psyc&uac=292598PZ&spon=12&impID=2194053&faf=1 More than 10 years of marijuana use is associated with the development of testicular germ cell tumor (TGCT), but the quality of the evidence is "low strength" and there is insufficient evidence to support an association between ever having used marijuana and other types of cancer. These are the conclusions from a new systematic review and meta-analysis published online today in JAMA Open Network. Lead author Mehrnaz Ghasemiesfe, MD, Northern California Institute of Research and Education, San Francisco, and colleagues explain that they wondered if marijuana smoke might cause [...]

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Emergency department presentations related to acute toxicity following recreational use of cannabis products in Switzerland, Yasmin Schmid et al., 2019

Emergency department presentations related to acute toxicity following recreational use of cannabis products in Switzerland Yasmin Schmid, Irene Scholz, Laura Mueller, Aristomenis K. Exadaktylos, Alessandro Ceschi, Matthias E. Liechti, Evangelia Liakoni Drug and Alcohol Dependence, 2019. https://doi.org/10.1016/j.drugalcdep.2019.107726   A B S T R A C T Background : Concomitant use of cannabis and other psychoactive substances is common and it is often difficult to differentiate its acute effects from those of other substances. This study aimed to characterize the acute toxicity of cannabis with and without co-use of other substances. Methods : Retrospective analysis of cases presenting at the emergency departments of three large hospitals in Switzerland due [...]

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An update on cannabis use disorder with comment on the impact of policy related to therapeutic and recreational cannabis use, Alan J. Budney et al., 2019

An update on cannabis use disorder with comment on the impact of policy related to therapeutic and recreational cannabis use Alan J. Budney,· Michael J. Sofis,· Jacob T. Borodovsky European Archives of Psychiatry and Clinical Neuroscience, 2019 https://doi.org/10.1007/s00406-018-0976-1 © Springer-Verlag GmbH Germany, part of Springer Nature 2019   Abstract : Confusion and controversy related to the potential for cannabis use to cause harm, or alternatively to provide benefit, continues globally. This issue has grown in intensity and importance with the increased recognition of the public health implications related to the escalation of the legalization of cannabis and cannabinoid products. This selective overview and commentary attempt to succinctly [...]

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