EMA Panel Backs Esketamine Nasal Spray for Resistant Depression Megan Brooks Medscape Medical News, October 18, 2019 The Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) has recommended approval of esketamine nasal spray (Spravato, Janssen-Cilag) in combination with a selective serotonin reuptake inhibitor (SSRI) or serotonin and norepinephrine reuptake inhibitor (SNRI) for adults with treatment-resistant major depressive disorder (TRD). Patients are considered to have TRD if they have not responded to at least two different treatments with antidepressants in the current moderate to severe depressive episode. Spravato will be available as a 28 mg nasal spray solution. The safety and [...]
Lire la suiteThe therapeutic potential of harmine and ayahuasca in depression : Evidence from exploratory animal and human studies Flávia de Lima Osório, Ligia Ribeiro Horta de Macedo, João Paulo Machado de Sousa, Joel Porfírio Pinto, João Quevedo, José Alexandre de Souza Crippa and Jaime Eduardo C. Hallak The Ethnopharmacology of Ayahuasca, chapitre 5, 2011, 75-85 Editor : Rafael Guimarães dos Santos ISBN: 978-81-7895-526-1 Abstract The high prevalence and the socio-functional impairment associated with depressive disorders, added to the limitations of currently available treatments, justify the search for novel pharmacological strategies for the management of depression. This chapter presents the major results of animal and human studies conducted [...]
Lire la suiteAyahuasca for Addiction ? That's a Trip Ayahuasca has long been used to heal the spirit, so what about addiction? Adi Jaffe, Psychology Today Posted Dec 10, 2018 https://www.psychologytoday.com/us/blog/all-about-addiction/201812/ayahuasca-addiction-thats-trip Doctors have been prescribing drugs to treat substance addictions for decades. Most commonly known is the use of buprenorphine and naloxone (Suboxone) in opioid addiction which provides some opioid activation, helping with withdrawal and cravings, without the same “high” and many of the associated psychosocial effects of illicit drug use. But Suboxone isn’t the only one – methadone, modafinil, naltrexone, ketamine, and many more examples exist in which the use of a chemical has been prescribed to help [...]
Lire la suiteAyahuasca in Adolescence : A Neuropsychological Assessment Evelyn Doering-Silveira, Enrique Lopez, Charles S. Grob, Marlene Dobkin de Rios, Luisa K. Alonso, Cristiane Tacla,Itiro Shirakawa, Paulo H. Bertolucci, & Dartiu X. Da Silveira Journal of Psychoactive Drugs, 2005, 37, (2), 123-128. Abstract The purpose of the study was to evaluate neuropsychologically adolescents who use ayahuasca in a religious context. A battery of neuropsychological tests was administered to adolescents who use ayahuasca. These subjects were compared to a matched control group of adolescents who did not use ayahuasca. The controls were matched with regards to sex, age, and education. The neuropsychological battery included tests of speeded [...]
Lire la suiteAyahuasca in Adolescence : A Preliminary Psychiatric Assessment Dartiu Xavier Da Silveira; Charles S. Grob; Marlene Dobkin de Rios; Enrique Lopez; Luisa K. Alonso; Cristiane Tacla & Evelyn Doering-Silveira Journal of Psychoactive Drugs, 2005, 37, (2), 129-133. www.neip.info Abstract Ayahuasca is believed to be harmless for those (including adolescents) drinking it within a religious setting. Nevertheless controlled studies on the mental/ psychiatric status of ritual hallucinogenic ayahuasca concoction consumers are still lacking. In this study, 40 adolescents from a Brazilian ayahuasca sect were compared with 40 controls matched on sex, age, and educational background for psychiatric symptomatology. Screening scales for depression, anxiety, alcohol consumption patterns (abuse), [...]
Lire la suiteEffects of a Psychedelic, Tropical Tea, Ayahuasca, on the Electroencephalographic (EEG) Activity of the Human Brain during a Shamanistic Ritual Erik Hoffmann, Jan M. Keppel Hesselink, Yatra-W.M. da Silveira Barbosa MAPS Bulletin, Multidisciplinary Association for Psychedelic Studies, USA, Spring 2001, pp 25-30 Abstract Eight channels of EEG from 12 volunteers participating in a workshop in Brazil were recorded under field conditions before and after a shamanistic ritual in which the psychoactive tea, ayahuasca, was consumed. Following three doses of the tea, the subjects showed strong and statistically significant increases of both EEG alpha (8-13Hz) and theta (4-8Hz) mean amplitudes compared to baseline while beta [...]
Lire la suiteBook Review : The psychedelic religion of mystical consciousness, Rick Strassman William A. Richards Sacred Knowledge: Psychedelics and Religious Experiences Columbia University Press, New York, 2016, 244 pp. Hardback ISBN: 978-0-231-17406-0 Journal of Psychedelic Studies, 2018 Doi : 10.1556/2054.2018.003 With an extreme range of terms for psychedelic drugs – from “schizotoxic” to “entheogenic” – “psychedelic,” nonetheless remains the most salient one. These substances manifest or disclose aspects of the mind of those who take them as well as the mind of those who study them. Proponents for the innumerable terms for these drugs are all able to adduce supportive evidence. Necessarily, this evidence is a subjective experience, [...]
Lire la suiteA History of Drug Use : Mind-Altering Drugs in Social Context Eric Shepperd January 21, 2017, 26 p. It seems that an intrinsic property of consciousness is a desire to alter itself. The natural world is full of tools for changing the functioning of the mind, and both humans and nonhuman animals have used many different drugs throughout history. Some are derived directly from plant or animal sources, while others are refined extracts, or synthesized by purely chemical methods. Many of the drugs in use today are applied primarily for physiologically therapeutic purposes, while others have primarily psychological components, or a combination thereof. Psychoactive [...]
Lire la suiteLa recherche sur les microdoses de substances psychédéliques. James Fadiman, Sophie Korbe et les « micro-doses » Vittorio Biancardi Chimères, 2017/1 N° 91 | pages 139 à148 Les programmes de recherche qui ont été menés légalement sur des dizaines de milliers de patients, à partir de la moitié du vingtième siècle, ont démontré qu’un usage soigneusement réduit de lsd peut se révéler efficace contre certaines psychopathologies, et bénéfique pour le développement personnel et spirituel. En outre, de récentes études ont mis en évidence que la prise de petites doses de lsd peut permettre entre autres une augmentation des capacités cognitives chez des sujets [...]
Lire la suiteLe microdosage de substances psychédéliques : bref historique et nouveaux axes de recherche Vittorio Biancardi Revue CIRCE, 2019, 11, Résumé Le micro-dosage est un phénomène social de plus en plus répandu parmi la communauté des consommateurs et consommatrices des substances dites psychédéliques. Il consiste une consommation d’un dixième de la dose typique de substance (principalement LSD ou Psilocybine) de façon fréquente, deux ou trois fois par semaine, pour améliorer les capacités cognitives ou comme auto-thérapie. L’analyse de ce phénomène est actuellement très fragmentaire et inconsistante, tant du point de vue des sciences humaines que du point de vue des sciences dites «dures». L’objectif de [...]
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