Cannabidiol Reduces Brain Damage and Improves Functional Recovery After Acute Hypoxia-Ischemia in Newborn Pigs Hector LAFUENTE, Francisco J. ALVAREZ, M. Ruth PAZOS, Antonia ALVAREZ, M. Carmen REY-SANTANO, Victoria MIELGO, Xabier MURGIA-ESTEVE, Enrique HILARIO, and Jose MARTINEZ-ORGADO Pediatric Research, 2011, 70, 272–277. ABSTRACT : Newborn piglets exposed to acute hypoxia-ischemia (HI) received i.v. cannabidiol (HI CBD) or vehicle (HI VEH). In HI VEH, 72 h post-HI brain activity as assessed by amplitudeintegrated EEG (aEEG) had only recovered to 42 9% of baseline, near-infrared spectroscopy (NIRS) parameters remained lower than normal, and neurobehavioral performance was abnormal (27.8 2.3 points, normal 36). [...]
Lire la suiteMarijuana use and coronary artery disease in young adults Jeremy R. Burt, Ali M. Agha, Basel Yacoub, Aryan Zahergivar, Julie Pepe PLoS ONE, 2020, 15, (1), e0228326, 1-8. Doi : 10.1371/journal.pone.0228326 Abstract Background Marijuana is the most popular drug of abuse in the United States. The association between its use and coronary artery disease has not yet been fully elucidated. This study aims to determine the frequency of coronary artery disease among young to middle aged adults presenting with chest pain who currently use marijuana as compared to nonusers. Methods In this retrospective study, 1,420 patients with chest pain or angina equivalent were studied. Only men between 18 [...]
Lire la suiteModern Clinical Research on LSD Matthias E Liechti Neuropsychopharmacology, 2017, 42, 2114–2127. doi : 10.1038/npp.2017.86 All modern clinical studies using the classic hallucinogen lysergic acid diethylamide (LSD) in healthy subjects or patients in the last 25 years are reviewed herein. There were five recent studies in healthy participants and one in patients. In a controlled setting, LSD acutely induced bliss, audiovisual synesthesia, altered meaning of perceptions, derealization, depersonalization, and mystical experiences. These subjective effects of LSD were mediated by the 5-HT2A receptor. LSD increased feelings of closeness to others, openness, trust, and suggestibility. LSD impaired the recognition of sad and fearful faces, reduced left [...]
Lire la suitePsychedelics and potential benefits in “healthy normals”: A review of the literature Sam GANDY Journal of Psychedelic Studies, 2019, 3, (3), 280–287. Doi : 10.1556/2054.2019.029 We are in the midst of a psychedelic research renaissance. With research examining the efficacy of psychedelics as a treatment for a range of mental health indications still in its early stages, there is an increasing body of research to show that careful use of psychedelics can yield a variety of benefits in “healthy normals” and so lead to “the betterment of well people.” Psychedelics have been found to modulate neuroplasticity, and usage in a supportive setting can result [...]
Lire la suiteNeurocognitive performance and serial intravenous subanesthetic ketamine in treatment-resistant depression Paulo R. Shiroma, C. Sophia Albott, Brian Johns, Paul Thuras, Joseph Wels and Kelvin O. Lim The International Journal of Neuropsychopharmacology, 2014, Volume 17, Issue 11, 1805–1813, Doi : 10.1017/S1461145714001011 Abstract The N-methyl-D-aspartate glutamate receptor antagonist ketamine has demonstrated rapid anti-depressant effects in treatment-resistant depression (TRD). However, evaluation of ketamine's neurocognitive aspects in TRD has started to be explored. This study aims to (1) examine baseline neurocognitive performance and change in severity of depressive symptoms through six ketamine infusions, (2) examine the neurocognitive effects after completion of serial infusions and whether changes were associated to [...]
Lire la suiteA phenomenology of subjectively relevant experiences induced by ayahuasca in Upper Amazon vegetalismo tourism Tom John Wolff, Simon Ruffell, Nigel Netzband and Torsten Passie Journal of Psychedelic Studies, 2018 Doi : 10.1556/2054.2019.007 Aims : This heuristic study reports observations on the phenomenology of ayahuasca experiences of nine foreign tourist participants of an ayahuasca retreat in Peru. Methods : Narrative interviews, reflecting individual experiences after ayahuasca “night ceremony,” have been analyzed by qualitative content analysis using a data-driven strategy in order to extract themes and categories inherent in the interviews. Previously, a demographic questionnaire was given. The dose–response connection was uncontrolled, which is typical for this [...]
Lire la suiteThe effects of microdose LSD on time perception: a randomised, double-blind, placebo-controlled trial Steliana Yanakieva, Naya Polychroni, Neiloufar Family, Luke T. J. Williams, David P. Luke, Devin B. Terhune Psychopharmacology, 2018 Doi : 10.1007/s00213-018-5119-x Abstract Rationale : Previous research demonstrating that lysergic acid diethylamide (LSD) produces alterations in time perception has implications for its impact on conscious states and a range of psychological functions that necessitate precise interval timing. However, interpretation of this research is hindered by methodological limitations and an inability to dissociate direct neurochemical effects on interval timing from indirect effects attributable to altered states of consciousness. Methods : We conducted a randomised, double-blind, [...]
Lire la suiteA systematic study of microdosing psychedelics RESEARCH ARTICLE Vince Polito, Richard J. Stevenson PLoS ONE, 2019, 14, (2), e0211023. Doi : 10.1371/journal.pone.0211023 Abstract The phenomenon of ‘microdosing’, that is, regular ingestion of very small quantities of psychedelic substances, has seen a rapid explosion of popularity in recent years. Individuals who microdose report minimal acute effects from these substances yet claim a range of long-term general health and wellbeing benefits. There have been no published empirical studies of microdosing and the current legal and bureaucratic climate makes direct empirical investigation of the effects of psychedelics difficult. In Study One we conducted a systematic, observational investigation of individuals [...]
Lire la suitePsilocybin Benefits in Cancer Sustained Nearly 5 Years Later Nancy A. Melville Medscape, January 28, 2020 Medscape Medical News © 2020 Cancer patients who were treated with a one-time, single dose of the psychedelic drug psilocybin, combined with psychotherapy, showed significant benefits on measures of emotional and existential distress nearly 5 years after receiving the therapy, new research indicates. In addition to reporting improved well-being or life satisfaction, some patients rated the treatment as being "among the most personally meaningful and spiritually significant experiences of their lives," the authors note. The study, the longest-spanning evaluation to date of the effects of psilocybin in the treatment of cancer-related psychiatric distress, was [...]
Lire la suiteChanges in Spirituality Among Ayahuasca Ceremony Novice Participants Stephen M. Trichter A Clinical Research Project Submitted to the Faculty of Argosy University, San Francisco Bay Area In partial fulfillment of the requirements for The degree of Doctor of Psychology Point Richmond, California Copyright May 2006 _____________________________ CHAPTER I : INTRODUCTION Context of the Problem Psychiatry and clinical psychology have developed with the aim of relieving maladaptive psychological symptoms, partially through the use of medical technology. Presently, the field encourages the use of anti-depressants, anti-anxiety agents, and antipsychotics to relieve symptoms from which patients suffer. Despite continuous breakthroughs in psychiatric medicine, many writers feel that this approach is questionable. For [...]
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