Étiquette : états modifiés de conscience

The neurobiology of psychedelic drugs : implications for the treatment of mood disorders, Franz X. Vollenweider and Michael Kometer, 2010

The neurobiology of psychedelic drugs : implications for the treatment of mood disorders Franz X. Vollenweider and Michael Kometer Perspectives, www.nature.com, 2010, 11, 642-651.   Abstract After a pause of nearly 40 years in research into the effects of psychedelic drugs, recent advances in our understanding of the neurobiology of psychedelics, such as lysergic acid diethylamide (LSD), psilocybin and ketamine have led to renewed interest in the clinical potential of psychedelics in the treatment of various psychiatric disorders. Recent behavioural and neuroimaging data show that psychedelics modulate neural circuits that have been implicated in mood and affective disorders, and can reduce the clinical symptoms of [...]

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Adverse Reactions to Psychedelic Drugs. A Review of the Literature, Rick J. STRASSMAN, 1984.

Adverse Reactions to Psychedelic Drugs. A Review of the Literature Rick J. STRASSMAN, M.D. THE JOURNAL OF NERVOUS AND MENTAL DISEASE, 1984, VOL. 172, NO. 10, 577-595. DOI : 10.1097/00005053-198410000-00001   The use of naturally occurring and synthetically derived compounds for their "psychedelic" effects has been a part of human culture for thousands of years. The basic pharmacology of the major synthetic psychedelic compounds primarily lysergic acid diethylamide [LSD]-25 is described and reference is made to their potentially beneficial psychological effects. Adverse reactions, defined as dysphoric and/or maladaptive/dysfunctional responses to the use of these drugs, sometimes require careful clinical judgment in order to diagnose. These reactions [...]

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The Consciousness Research of Stanislav Grof, Richard Yensen & Donna Dryer, 1998

The Consciousness Research of Stanislav Grof : A Cosmic Portal Beyond Individuality By Richard Yensen, Ph.D. and Donna A. Dryer, M.D., M.P.H. ©1998 Richard Yensen & Donna Dryer     I. Introduction Stanislav Grof began his research in Prague, Czechoslovakia, as a psychiatric resident, in the late 1950’s. His initial observations seemed to confirm and offer a laboratory proof for many of the basic tenets of Freudian psychoanalytic thought. At that time his conclusion was politically unsettling because psychoanalysis was repressed in the iron curtain countries. Forty years later the outcome of Grof’s continued research is a theoretical framework for understanding human consciousness. His theory has [...]

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De Cannabis Bono, François-Rodolphe Ingold et al., 2020

De Cannabis Bono François-Rodolphe INGOLD, Charlis D. KAPLAN, Christian SUEUR Annales Médico-Psychologiques, 2020, 178, 296-302 Doi : 10.16/j.amp.2020.01.018   Résumé Les usages du cannabis, en médecine et dans les traditions populaires, sont divers et anciens, ils ont été freinés depuis un siècle par la prohibition. Nous assistons depuis une trentaine d’années à un renouveau des pratiques sociales – production, distribution, usages – liées au cannabis. La découverte du système endocannabinoïde introduit un élément nouveau en faveur de l’utilisation médicale de cette plante. Les indications des cannabinoïdes en psychiatrie sont potentiellement nombreuses et demandent à être discutées. Il en va de même pour les mécanismes à l’œuvre qui restent à identifier, [...]

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Therapeutic Potential of Psychedelic Drugs, Justin Briglio, 2015

Therapeutic Potential of Psychedelic Drugs Justin Briglio University of Maine, 2015, 31 p.   Table of Contents Introduction......................................................................................................................................3 History of Psychedelic Research.....................................................................................................6 Recent Research...............................................................................................................................8 Neurobiology of Psychedelics.........................................................................................................9 Therapeutic Potential of Psilocybin...............................................................................................12 Therapeutic Potential of LSD........................................................................................................15 Therapeutic Potential of Ayahuasca..............................................................................................19 Therapeutic Potential of Ibogaine..................................................................................................22 Conclusion.....................................................................................................................................26 References......................................................................................................................................28 A psychedelic compound is a psychoactive drug whose main action is to alter perception and cognition. Psychedelics are distinctive from other psychoactive drugs in that they alter the mind, whereas opiates or stimulants alter the mood (Meyer & Quenzer, 2013). Psychedelics affect nature of consciousness itself and access otherwise unknown states of consciousness, as opposed to affecting the degree or extent of one's consciousness and inducing proverbial moods such as [...]

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The effects of microdose LSD on time perception: a randomised, double-blind, placebo-controlled trial, Steliana Yanakieva et al., 2018

The effects of microdose LSD on time perception: a randomised, double-blind, placebo-controlled trial Steliana Yanakieva, Naya Polychroni, Neiloufar Family, Luke T. J. Williams, David P. Luke, Devin B. Terhune Psychopharmacology, 2018 Doi : 10.1007/s00213-018-5119-x   Abstract Rationale : Previous research demonstrating that lysergic acid diethylamide (LSD) produces alterations in time perception has implications for its impact on conscious states and a range of psychological functions that necessitate precise interval timing. However, interpretation of this research is hindered by methodological limitations and an inability to dissociate direct neurochemical effects on interval timing from indirect effects attributable to altered states of consciousness. Methods : We conducted a randomised, double-blind, [...]

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A Comparative Review of the Neuro- Psychopharmacology of Hallucinogen-Induced Altered States of Consciousness : The Uniqueness of Some Hallucinogens, Ümit Sayin, 2012

A Comparative Review of the Neuro- Psychopharmacology of Hallucinogen-Induced Altered States of Consciousness : The Uniqueness of Some Hallucinogens Ümit Sayin NeuroQuantology, June 2012, Volume 10, Issue 2,  316-340. eISSN 1303-5150   ABSTRACT Altered states of consciousness induced by hallucinogens (H-ASC) is still a vaguely understood phenomenon. Taken the diverse psychological effects they exert, the main mechanism of action of hallucinogens; LSD, ibogaine, THC, PCP, MDMA, methamphetamine, mescaline, psilocybin and DMT, of which psychological effects are discussed in the article, are not properly understood and explained by the modern methods of neuroscience due to the lack of vigorous research. The involvement of some receptors, such as, [...]

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Psychedelics and music : neuroscience and therapeutic implications, Frederick S. Barrett et al., 2018

Psychedelics and music : neuroscience and therapeutic implications Frederick S. Barrett, Katrin H. Preller & Mendel Kaelen International Review of Psychiatry, 2018 https://doi.org/10.1080/09540261.2018.1484342   ABSTRACT From the beginning of therapeutic research with psychedelics, music listening has been consistently used as a method to guide or support therapeutic experiences during the acute effects of psychedelic drugs. Recent findings point to the potential of music to support meaning-making, emotionality, and mental imagery after the administration of psychedelics, and suggest that music plays an important role in facilitating positive clinical outcomes of psychedelic therapy. This review explores the history of, contemporary research on, and future directions regarding the use [...]

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CBD & the Psychedelic Receptor, Lex Pelger, projectCBD.org, 2019

CBD & the Psychedelic Receptor Lex Pelger On March 11, 2018 (Updated on April 16, 2019) https://www.projectcbd.org/science/cbd-psychedelic-receptor CBD and LSD bind to the same serotonin receptor, which mediates psychedelic altered states. But cannabidiol has anti-psychotic properties and doesn't cause hallucinations. In a shorthand that drives scientists mad, serotonin is often called ‘the neurotransmitter of happiness.’ This tag is especially troublesome as more and more flaws become apparent in the ‘serotonin hypothesis’ of depression – the idea that depression is caused by a serotonin deficit, which a pill (a serotonin reuptake inhibitor) could correct.1  Serotonin is a complex molecule in the brain and the [...]

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The Varieties of Psychedelic Epistemology, Chris Letheby, 2019

The Varieties of Psychedelic Epistemology Chris Letheby Published in N. Wyrd, D. Luke, A. Tollan, C. Adams, and D. King (eds.) : "Psychedelicacies: more food for thought from Breaking Convention", Strange Attractor Press, 2019.   INTRODUCTION Is it possible to gain knowledge1 by taking psychedelic2 drugs? One influential answer is ‘yes’: according to this conception, by inducing mystical states of consciousness, psychedelics afford direct knowledge of supernatural, transcendent dimensions of reality. This is an entheogenic conception of the drugs as agents that “generate the divine within”. A second influential answer is ‘no’: since materialism or physicalism3 is true, there are no transcendent realities, and psychedelics [...]

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