Étiquette : effets indésirables

Medical Marijuana Use in Oncology : A Review, Gianna Wilkie et al., 2016

Medical Marijuana Use in Oncology : A Review Gianna Wilkie,  Bachir Sakr, Tina Rizack JAMA Oncology, 2016, 2, (5), 670-675. doi:10.1001/jamaoncol.2016.0155   IMPORTANCE : Medicinal marijuana use is currently legal in 23 states and the District of Columbia. As more states approve marijuana use for medical indications, physicians will be asked by their patients for more information regarding the risks and benefits of use. This article reviews the history, adverse effects, and proposed mechanisms of action of marijuana and summarizes the available literature regarding symptom relief and therapeutic value in patients with cancer. OBSERVATIONS : Marijuana in oncologymay have potential for use as an antiemetic, for [...]

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LSD before Leary – Sidney Cohen’ s Critique of 1950s Psychedelic Drug Research, Steven J. Novak, 1997

LSD before Leary - Sidney Cohen' s Critique of 1950s Psychedelic Drug Research Steven J. Novak Isis, 1997, Vol. 88, No. 1, pp. 87-110. http://links.jstor.org/sici?sici=0021-1753%28199703%2988%3A1%3C87%3ALBLSCC%3E2.0.CO%3B2-W   ABSTRACT In 1962 Sidney Cohen presented the medical community with its first warning about the dangers of the drug LSD. LSD had arrived in the United States in 1949 and was originally perceived as a psychoto-mimetic capable of producing a model psychosis. But in the mid 1950s intellectuals in Southern California redefined LSD as a psychedelic capable of producing mystical enlightenment. Though LSD was an investigational drug, authorized only for experimental use, by the late 1950s psychiatrists and psychologists were [...]

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Neurotoxicity and LSD treatment: a follow-up study of 151 patients in Denmark, Jens Knud Larsen, 2016

Neurotoxicity and LSD treatment : a follow-up study of 151 patients in Denmark Jens Knud Larsen University Hospital of Aarhus, Risskov, Denmark History of Psychiatry, 2016, Vol. 27, (2), 172–189 DOI: 10.1177/0957154X16629902   Abstract LSD was introduced in psychiatry in the 1950s. Between 1960 and 1973, nearly 400 patients were treated with LSD in Denmark. By 1964, one homicide, two suicides and four suicide attempts had been reported. In 1986 the Danish LSD Damages Law was passed after complaints by only one patient. According to the Law, all 154 applicants received financial compensation for LSD-inflicted harm. The Danish State Archives has preserved the case material of 151 [...]

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The Association of Salvia divinorum and Psychotic Disorders: A Review of the Literature and Case Series, Joseph El-Khoury & Nayiri Sahakian, 2015

The Association of Salvia divinorum and Psychotic Disorders: A Review of the Literature and Case Series Joseph El-Khoury & Nayiri Sahakian Journal of Psychoactive Drugs, 2015, 47, 4, 286-292 https://doi.org/10.1080/02791072.2015.1073815   Abstract The association of substance abuse and psychotic disorders is of interest to clinicians, academics, and lawmakers. Commonly abused substances, such as cannabis, cocaine, amphetamines, and alcohol, have all been associated with substance-induced psychosis. Hallucinogens can induce desired psychedelic effects and undesirable psychomimetic reactions. These are usually transient and resolve once the duration of action is over. Sometimes, these effects persist, causing distress and requiring intervention. This article focuses on the hallucinogenic substance Salvia divinorum, [...]

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Motives and Side-Effects of Microdosing With Psychedelics Among Users, Nadia R. P. W. Hutten et al., 2019

Motives and Side-Effects of Microdosing With Psychedelics Among Users Nadia R. P. W. Hutten, Natasha L. Mason, Patrick C. Dolder, Kim P. C. Kuypers International Journal of Neuropsychopharmacology, 2019, 1–9 doi:10.1093/ijnp/pyz029   Abstract Background : Microdosing with psychedelics has gained considerable media attention where it is portrayed as a performance enhancer, especially popular on the work floor. While reports are in general positive, scientific evidence about potential negative effects is lacking aside from the prevalence and motives for use. The present study addressed this gap by surveying psychedelic users about their experience with microdosing including their dosing schedule, motivation, and potential experienced negative effects. Methods : An [...]

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The abuse potential of medical psilocybin according to the 8 factors of the Controlled Substances Act, Matthew W. Johnson et al., 2018

The abuse potential of medical psilocybin according to the 8 factors of the Controlled Substances Act Matthew W. Johnson, Roland R. Griffiths, Peter S. Hendricks, Jack E. Henningfiel Neuropharmacology, 2018, 142, 143-166. https://doi.org/10.1016/j.neuropharm.2018.05.012 a b s t r a c t This review assesses the abuse potential of medically-administered psilocybin, following the structure of the 8 factors of the US Controlled Substances Act (CSA). Research suggests the potential safety and efficacy of psilocybin in treating cancer-related psychiatric distress and substance use disorders, setting the occasion for this review. A more extensive assessment of abuse potential according to an 8-factor analysis would eventually be required to [...]

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Associations between Adolescent Cannabis Use and Neuropsychological Decline : A Longitudinal Co-Twin Control Study, Madeline H. Meier et al., 2018

Associations between Adolescent Cannabis Use and Neuropsychological Decline : A Longitudinal Co-Twin Control Study Madeline H. Meier, Avshalom Caspi, Andrea Danese, Helen L. Fisher, Renate Houts, Louise Arseneault, & Terrie E. Moffitt Addiction. 2018, 113, (2), 257-265. doi: 10.1111/add.13946.   Abstract Aims : This study tested whether adolescents who used cannabis or met criteria for cannabis dependence showed neuropsychological impairment prior to cannabis initiation and neuropsychological decline from before to after cannabis initiation. Design : A longitudinal co-twin control study. Setting and Participants : Participants were 1,989 twins from the Environmental Risk (E-Risk) Longitudinal Twin Study, a nationally representative birth cohort of twins born in England and Wales [...]

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Potential Therapeutic Effects of Psilocybin, Matthew W. Johnson & Roland R. Griffiths, 2017

Potential Therapeutic Effects of Psilocybin Matthew W. Johnson & Roland R. Griffiths Neurotherapeutics, 2017, 14, 734–740 DOI 10.1007/s13311-017-0542-y Abstract Psilocybin and other 5-hydroxytryptamine2A agonist classic psychedelics have been used for centuries as sacraments within indigenous cultures. In the mid-twentieth century they were a focus within psychiatry as both probes of brain function and experimental therapeutics. By the late 1960s and early 1970s these scientific inquires fell out of favor because classic psychedelics were being used outside of medical research and in association with the emerging counter culture. However, in the twenty-first century, scientific interest in classic psychedelics has returned and grown as a result of [...]

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Lysergic acid diethylamide : a drug of ‘use’?, Saibal Das et al., 2016

Lysergic acid diethylamide : a drug of ‘use’ ? Saibal Das, Preeti Barnwal, Anand Ramasamy, Sumalya Sen and Somnath Mondal Therapeutic Advances in Psychopharmacology, 2016, Vol. 6, (3), 214–228 DOI: 10.1177/2045125316640440   Abstract : Lysergic acid diethylamide (LSD), described as a classical hallucinogen, began its journey from the middle of the last century following an accidental discovery. Since then, it was used as a popular and notorious substance of abuse in various parts of the world. Its beneficial role as an adjunct to psychotherapy was much unknown, until some ‘benevolent’ experiments were carried out over time to explore some of its potential uses. But, many [...]

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Psychedelic drug use in healthy individuals: a review of benefits, costs, and implications for drug policy, James W.B. Elsey, 2017

Psychedelic drug use in healthy individuals : a review of benefits, costs, and implications for drug policy, James W.B. Elsey Roeterseiland Campus, Building G, 129 Nieuwe Achtergracht, Amsterdam, Postbus 15933, Noord Holland, 1001 NK, the Netherlands. Drug Science, Policy and Law, 2017, 3, 1–11. doi: 10.1177/2050324517723232   Abstract The potential of psychedelic drugs in the treatment of mental health problems is increasingly being recognized. However, relatively little thrust has been given to the suggestion that individuals without any mental health problems may benefit from using psychedelic drugs, and that they may have a right to do so. This review considers contemporary research into the use of psychedelic [...]

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