As CBD Oil Flirts with Mainstream, Questions Mount Kathleen Doheny Medscape, June 11, 2018 Anxiety is a given for Jessica Singer, 25, who juggles her job at a marijuana dispensary with her night-time gigs as a stand-up comedian in Los Angeles. So when it’s time for bed, "I can't turn off my brain,'' she says. Now she does, with the help of a new bedtime ritual -- a ''snack" of two gummy bears containing CBD. CBD, or cannabidiol, is a substance from marijuana that lacks the ''high'' of the THC (tetrahydro-cannabinol) also found in marijuana. The remedy is affordable for her -- about $35 [...]
Lire la suiteBibliographie CANNABINOÏDES et Traitement des Nausées et Vomissements Docteur Christian SUEUR, GRECC, 2e édition, janvier 2020. Le Cannabis comme anti-émétique : Les prescriptions médicales, chez les adultes (THC naturel ou synthétique - Nabilone) comme chez les enfants (delta 8-THC, Abrahamov et al, 1995), ont débutées dès 1975. L’efficacité a été prouvée dans de nombreux essais cliniques, et de nombreuses méta-analyses (8/9 pour le cannabis et 3/3 pour le Nabilone, Penta et al, 1981). Par contre les effets psychotropiques peuvent être mal supportés par de nombreux patients, et justifie l’arrêt, ou la diminution des doses. Les associations variables THC/CBD présente un intérêt probable. Aucun effet indésirable persistant ou fatal [...]
Lire la suiteBibliographie CANNABINOÏDES et Soins Palliatifs dans les pathologies cancéreuses Docteur Christian SUEUR, GRECC, janvier 2020. ("Work in Progress".... vos contributions seraient les bienvenues !) voir également : Bibliographie : Cannabinoides et traitement des nausées et vomissements
Lire la suiteCannabis in Cancer Care D.I. Abrams and M. Guzman Clinical Pharmacology & Therapeutics, 2015, 97, (6), 575-586. Doi : 10.1002/cpt.108 Cannabis has been used inmedicine for thousands of years prior to achieving its current illicit substance status. Cannabinoids, the active components of Cannabis sativa,mimic the effects of the endogenous cannabinoids (endocannabinoids), activating specific cannabinoid receptors, particularly CB1 found predominantly in the central nervous system and CB2 found predominantly in cells involved with immune function. Delta-9-tetrahydrocannabinol, themain bioactive cannabinoid in the plant, has been available as a prescriptionmedication approved for treatment of cancer chemotherapy-induced nausea and vomiting and anorexia associated with the AIDS wasting syndrome. Cannabinoidsmay [...]
Lire la suiteRegulation of nausea and vomiting by cannabinoids Linda A Parker, Erin M Rock and Cheryl L Limebeer British Journal of Pharmacology, 2011, 163, 1411-1422. Doi : 10.1111/j.1476-5381.2010.01176.x Abstract Considerable evidence demonstrates that manipulation of the endocannabinoid system regulates nausea and vomiting in humans and other animals. The anti-emetic effect of cannabinoids has been shown across a wide variety of animals that are capable of vomiting in response to a toxic challenge. CB1 agonism suppresses vomiting, which is reversed by CB1 antagonism, and CB1 inverse agonism promotes vomiting. Recently, evidence from animal experiments suggests that cannabinoids may be especially useful in treating the more difficult to control [...]
Lire la suiteRegulation of nausea and vomiting by cannabinoids and the endocannabinoid system Keith A. Sharkey, Nissar A. Darmani, and Linda A. Parker European Journal of Pharmacology, 2014 January 5; 722. doi : 10.1016/j.ejphar.2013.09.068. Abstract Nausea and vomiting (emesis) are important elements in defensive or protective responses that animals use to avoid ingestion or digestion of potentially harmful substances. However, these neurally-mediated responses are at times manifested as symptoms of disease and they are frequently observed as side-effects of a variety of medications, notably those used to treat cancer. Cannabis has long been known to limit or prevent nausea and vomiting from a variety of causes.This has [...]
Lire la suiteA reliable and validated LC-MS/MS method for the simultaneous quantification of 4 cannabinoids in 40 consumer products Qingfang Meng, Beth Buchanan, Jonathan Zuccolo, Mathieu-Marc Poulin, Joseph Gabriele, David Charles Baranowski PLoS ONE, 2018, 13, (5), e0196396. https://doi.org/10.1371/journal.pone.0196396 Abstract In the past 50 years, Cannabis sativa (C. sativa) has gone from a substance essentially prohibited worldwide to one that is gaining acceptance both culturally and legally in many countries for medicinal and recreational use. As additional jurisdictions legalize Cannabis products and the variety and complexity of these products surpass the classical dried plant material, appropriate methods for measuring the biologically active constituents is paramount to ensure [...]
Lire la suiteIACM-Bulletin du 13 Janvier 2020 Italie: Selon la Haute Cour, cultiver de petites quantités de cannabis à la maison n'est pas un crime Science/Homme: L'apport oral de graisse peut augmenter de deux fois la biodisponibilité systémique du THC Science/Homme: L'exercice a réduit le nombre de maux de tête et les niveaux d'anandamide chez les personnes souffrant de migraine Science/Homme: Selon une enquête les patients atteints du syndrome de la Tourette préfèrent le cannabis médical au THC pur et au Sativex En bref Un coup d'œil sur le passé Italie: Selon la [...]
Lire la suiteCannabis thérapeutique : la France tente l’expérience Le Quotidien du Pharmacien, 6 janvier 2020 - N°3567 By Damien Coulomb https://reputation.kantar.com//Public/IndexReview?ticket=B0676A6A0861C43FAA8FF14D942445F772837649EBF3AE141B18755109B597E279FDFAD2E9DA3F6A339F855835E70A2BA4435547C70966B06357667834105870033911B7545D63C0FA495FAE3543451038F55FF11906571C7AF35F378C6A16BAD3ED49B0933F8B41D99A90532AE551334818943393DA3A4BB381D488EDF9A29E Le 3 décembre dernier, les députés adoptaient définitivement la loi de financement de la sécurité sociale 2020. Un des amendements du texte, proposé par le député de l'Isère Olivier Véran, inscrit dans la loi l’expérimentation du cannabis thérapeutique dans le traitement d’un certain nombre d’indications. À partir du premier semestre 2020, les patients Français pourront se voir prescrire du cannabis thérapeutique dans le cadre d’une expérimentation de 2 ans.Selon le descriptif fourni par le comité scientifique spécialisé temporaire (CSST) rassemblé par l’Agence nationale de [...]
Lire la suiteCannabis Use Rising Faster Among Depressed Americans Lisa Rapaport Medscape - Dec 26, 2019. https://www.medscape.com/viewarticle/923160?nlid=133282_2052&src=WNL_mdplsnews_200103_mscpedit_psyc&uac=292598PZ&spon=12&impID=2232271&faf=1 (Reuters Health) - Regular cannabis use has risen more quickly among people with depression, and they're less likely to perceive it as risky, compared with people who aren't depressed, a U.S. study suggests. Researchers examined data collected from a total of almost 729,000 people aged 12 years and older between 2005 and 2017, including any prior-month cannabis use and any depression experienced over the previous year. By the final year of the study, about 19% of people with depression reported at least some cannabis use, compared with 8.7% of individuals without a recent history of [...]
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