Consideration of Ayahuasca for the Treatment of Posttraumatic Stress Disorder, Jessica L. NIELSON, & Julie D. MEGLER, 2012

Consideration of Ayahuasca for the Treatment of Post-traumatic Stress Disorder

Jessica L. NIELSON, & Julie D. MEGLER

MAPS Bulletin Annual Report, Winter 2012, 29-31.


THERE IS A GROWING AMOUNT OF RESEARCH on the development of PTSD and its various treatments. The fact that many people who su!er from PTSD struggle with the currently approved therapeutic options that are available to them suggests that we need to start exploring alternative strategies to treat this disorder.1 With the large number of veterans returning home from war that may have or will develop PTSD, we must have a diverse framework of therapy and integration in place for them.

Alternative options that are currently being explored for the treatment of PTSD include MDMA assisted psychotherapy 2 and marijuana.3 Current research indicates that ayahuasca mimics mechanisms of currently accepted treatments to PTSD, and its use as an alternative treatment for other types of disorders are also being considered.4

However, in order to understand the implications of ayahuasca in the treatment of PTSD, we need to understand how PTSD develops, which involves memory formation.

Memory can be divided into three types: perceptual memory, episodic memory, and semantic memory.5 Before it reaches conscious awareness, information from the outside world “rst passes through the sensory cortices of our brain. This is perceptual memory. Sensory input then travels up to higher processing regions. Within our limbic system lies the hippocampus and amygdala. The cognitive aspect of memory occurs in the hippocampus. There we are able to perceive the sensory information and form “episodic” memories. The amygdala links the episodic memory to the associated emotions. 5 At this stage, when an event is recalled the original sensations and emotions are replayed with it.

Over time, relevant information from episodic memory is transferred to the neocortex to create semantic memory networks. Here the information is integrated into your general knowledge, and becomes available for understanding events in the future. It is in the cortex that we assign meaning to our memories. A feedback loop from the cortex to the hippocampus then tells it to weaken the episodic memory.5 The memory can then be recalled without provoking the original sensations and emotions.

In PTSD, the brain fails to appropriately consolidate and integrate episodic memories into the semantic memory system.5 The memory and its associated emotions become trapped in the hippocampus, so that whenever the adverse memory is triggered it is recalled as if the traumatic event is being re-experienced.

The resulting hyperarousal leads many trauma victims to develop maladaptive coping mechanisms. In an attempt to prevent stimulation of intense fear, they seek ways, such as substance abuse, to avoid or numb out to triggers.

The American Psychiatric Association (APA) outlines three approaches to the treatment of PTSD: psychopharmacology, psychotherapy, and education and support. The goal of treatment is to eliminate or decrease flashbacks, nightmares, and other intrusive symptoms, allowing avoidance and arousal symptoms to subside.6 Successful recovery requires the disrupted process of cortical memory consolidation and integration to be reestablished. The patient must be able to discuss the traumatic event without replaying the original emotional intensity.

Once the images are no longer intrusive the event can be integrated into regular life. Only then will the victim come to understand their past trauma, and thus come to terms with it.7 In PTSD, the blockade of hippocampal outflow to the cortex needs to be reestablished so that the episodic memory can be weakened and the semantic memory created. Because it is limited to the cortical level of the brain, simple catharsis (expression of the traumatic event) is not sufficient to successfully treat PTSD symptoms. Effective treatments must target the limbic system.

When using psychotherapeutic treatments, many professionals in the field believe fear must be experienced before it can be reduced or eliminated. Exposure therapy is considered to be any therapy where the client is exposed to a fear memory as part of the therapy.7 With su”cient exposure, clients adapt to the trauma by altering its meaning in a way that desensitizes them to trauma-related triggers, thus reducing their experienced fear.6

Three types of exposure therapies that are recognized as evidence-based practice for treatment of PTSD include: prolonged exposure (flooding), cognitive restructuring, and eye movement desensitization and reprocessing (EMDR) therapy.8 These exposure therapies target the emotional aspects of fear memories mediated by the amygdala. Stimulation to these areas releases the memories to the cortex so they can #nally be processed and integrated into the victim’s life with meaning.

From the psychotherapeutic standpoint, ayahuasca is similar to exposure therapy. Intention-setting is a common ritual in many ayahuasca practices. Users with traumatic histories have the opportunity to set their intentions to their traumas. Recent studies indicate that the amygdala, and other brain areas associated with emotional processing, is activated with the administration of ayahuasca.9 Activation of the amygdala, the very region of the brain that is the source of fear-associated symptoms of PTSD, is seen with ayahuasca as well as exposure-based approaches.