Effects of psilocybin on hippocampal neurogenesis and extinction of trace fear conditionning CATLOW B.J., SONG S., PAREDES D.A., KIRSTEIN C.L., SANCHEZ-RAMOS J. Experimental Brain Research, 2013, 228, 481-491. Doi : 10.1007/s00221-013-3579-0 Abstract Drugs that modulate serotonin (5-HT) synaptic concentrations impact neurogenesis and hippocampal (HPC)-dependent learning. The primary objective is to determine the extent to which psilocybin (PSOP) modulates neurogenesis and thereby affects acquisition and extinction of HPC-dependent trace fear conditioning. PSOP, the 5-HT2A agonist 25I-NBMeO and the 5-HT2A/C antagonist ketanserin were administered via an acute intraperitoneal injection to mice. Trace fear conditioning was measured as the amount of time spent immobile in the presence of the conditioned [...]
Lire la suiteLysergic Acid Diethylamide and Psilocybin Revisited Mark A. Geyer Biological Psychiatry, 2015, Volume 78, Issue 8, 544-553 https://doi.org/10.1016/j.biopsych.2015.08.003 The past decade brought the beginnings of a renaissance in research on psychedelic drugs. Two articles in this issue of Biological Psychiatry signify that the resurrection of this long ignored topic has begun to mature and bear at least the promise of fruit. In the early 1970s, the onset of the “War on Drugs” brought with it a near-total hiatus in serious research on psychedelic drugs, especially in the United States. The resumption of credible work in this area has come from Switzerland, where many of [...]
Lire la suiteAcute Effects of Lysergic Acid Diethylamide in Healthy Subjects Yasmin Schmid, Florian Enzler, Peter Gasser, Eric Grouzmann, Katrin H. Preller, Franz X. Vollenweider, Rudolf Brenneisen, Felix Müller, Stefan Borgwardt, and Matthias E. Liechti Biological Psychiatry, 2014, Vol. 78, 8, 544-553 http://dx.doi.org/10.1016/j.biopsych.2014.11.015 ABSTRACT BACKGROUND : After no research in humans for .40 years, there is renewed interest in using lysergic acid diethylamide (LSD) in clinical psychiatric research and practice. There are no modern studies on the subjective and autonomic effects of LSD, and its endocrine effects are unknown. In animals, LSD disrupts prepulse inhibition (PPI) of the acoustic startle response, and patients with schizophrenia exhibit similar [...]
Lire la suiteModel Psychoses Induced by LSD-25 in Normals. I. Psychophysiological Investigations, with Special Reference to the Mechanism of the Paranoid Reaction Nicolas A. Bercel, Lee E. Travis, Leonard B. Olinger & E. Dreikurs AMA Archives of Neurology and Psychiatry, 1956, 588-611 republishing :Psychopathology: A Source Book (pp. 605–639). DOI: https://doi.org/10.4159/harvard.9780674367012 Keywords : Cardiovascular Agents, Ergot Alkaloids, adverse effects, Lysergic Acid Diethylamide, Mental Disorders, Oxytocics, Paranoid Disorders, Psychotic Disorders INTRODUCTION Experimental psychosis has a long history. It might have started with the administration of Cannabis indica boiling in wine to the ancient Hun warriors, resulting in mental obfuscation, as they were prepared for surgery because of wounds sustained in battle. [...]
Lire la suitePsychopathology and Psychophysiology of Minimal LSD-25 Dosage. A Preliminary Dosage-Response Spectrum Theodore GREINER, Neil R. BURCH, Robert EDELBERG AMA, Archives of Neurology & Psychiatry, 1958, 79, (2), 208-210. doi:10.1001/archneurpsyc.1958.02340020088016 Abstract Despite 14 years of investigation, as intensive as accorded any biologically active chemical, a gap remains in the systematic description of human response to lysergic acid diethylamide (LSD-25). The dramatic schizophrenic-like symptoms after doses of 40 μg to 100 μg have drawn the main interest. The threshold for activity is placed at 20 μg by general consensus, while perfunctory administration of smaller doses has left their effect uncertain. Accompanying those pharmacologic demonstrations has been [...]
Lire la suiteThe “Endless Trip” among the NPS Users : Psychopathology and Psychopharmacology in the Hallucinogen-Persisting Perception Disorder. A Systematic Review Laura Orsolini, Gabriele Duccio Papanti, Domenico De Berardis, Amira Guirguis, John Martin Corkery and Fabrizio Schifano Frontiers in Psychiatry, 2017, Vol. 8, article 240 doi: 10.3389/fpsyt.2017.00240 Hallucinogen-persisting perception disorder (HPPD) is a syndrome characterized by prolonged or reoccurring perceptual symptoms, reminiscent of acute hallucinogen effects. HPPD was associated with a broader range of LSD (lysergic acid diethylamide)-like substances, cannabis, methylenedioxy-methamphetamine (MDMA), psilocybin, mescaline, and psychostimulants. The recent emergence of novel psychoactive substances (NPS) posed a critical concern regarding the new onset of psychiatric symptoms/syndromes, including cases [...]
Lire la suiteSalvia divinorum : from recreational hallucinogenic use to analgesic and anti-inflammatory action Ulises Coffeen, Francisco Pellicer Journal of Pain Research, 2019, Volume 12, 1069-1076 DOI: 10.2147/JPR.S188619 Abstract : Salvia divinorum is a herbal plant native to the southwest region of Mexico. Traditional preparations of this plant have been used in illness treatments that converge with inflammatory conditions and pain. Currently, S. divinorum extracts have become popular in several countries as a recreational drug due to its hallucinogenic effects. Its main active component is a diterpene named salvinorin A (SA), a potent naturally occurring hallucinogen with a great affinity to the κ opioid receptors and with [...]
Lire la suiteLSD Psychotherapy Stanislas GROF Hunter House Ed., 1979 LIST OF CONTENTS 1. History of LSD Therapy The Discovery of LSD and its Psychedelic Effects Early Laboratory and Clinical LSD Research Therapeutic Experimentation With LSD Studies of Chemotherapeutic Properties of LSD LSD-Assisted Psychotherapy The Need for a Comprehensive Theory of LSD Therapy 2. Critical Variables in LSD Therapy Pharmacological Effects of LSD Personality of the Subject Personality of the Therapist or Guide Set and Setting of the Sessions 3. Psycholytic and Psychedelic Therapies with LSD : Towards an Integration of Approaches The Search for an Effective Technique of LSD Psychotherapy Advantages and Drawbacks of the Psycholytic Approach Pros and Cons of Psychedelic Therapy 4. Principles of LSD Psychotherapy The Preparation Period Psychedelic Sessions Integration [...]
Lire la suitePsycholytic and Psychedelic Therapy Research 1931-1995 : Introduction (A Complete International Bibliography) Torsten PASSIE Laurentius Publishers, Hannover, Germany, 1997 1 . INTRODUCTION "The future may teach us to exercise a direct influence, by means of particular chemical substances, on the amounts of energy and their distribution in the mental apparatus. It may be that there are other still undreamt of possibilities of therapy" . Sigmund Freud The present bibliography includes nearly all publications on the psychotherapeutic treatment procedures which are referred to as "psycholytic" or "psychedelic" therapy and their foundations. The methods in question use the psychic activating properties of specific substances to reinforce psychotherapeutic treatments. Some appropriate [...]
Lire la suitePsycholytic and Psychedelic Therapy Research 1931-1995 : A Complete International Bibliography Torsten Passie Laurentius Publishers, Hannover, Germany, 1997 Kleine bibliographische Reihe, vol. 3. (Ed. Raimund Dehmlow), ISSN 0941-6617 ISBN 3-931614-83-2 (cloth), ISBN 3-931614-84-0 (pbk) Preface I. Introduction 9 II. Organization of the Bibliography 21 III. Bibliography 1. General Approach and Basic Research 23 2. Psycholytic Therapy 42 3. Psychedelic Therapy 70 IV. Major Scientific Conferences on the Subject 88 V. Major Bibliographic Sources 89 Author Index 90 Subject Index 95 About the Authors 102
Lire la suite