Molecular Targets of the Phytocannabinoids-A Complex Picture Paula Morales, Dow P. Hurst, Patricia H. Reggio Progress in the Chemistry of Organic Natural Products, 2017 ; 103: 103–131. doi:10.1007/978-3-319-45541-9_4. 1 Introduction For centuries, hashish and marihuana, both derived from the Indian hemp Cannabis sativa L., have been used for their medicinal, as well as, their psychotropic effects. Phytocannabinoids are oxygen containing C21 aromatic hydrocarbons found in Cannabis sativa L. To date, over 120 phytocannabinoids have been isolated from Cannabis, including two compounds, (−)-trans-Δ9-tetrahydrocannabinol (Δ9-THC) and (−)-trans-Δ8-THC (Δ8-THC) that have been shown to bind to cannabinoid receptors and elicit the characteristic psychotropic effect associated with Cannabis [1]. [...]
Lire la suiteMolecular Pharmacology of Phytocannabinoids Sarah E. Turner, Claire M. Williams, Leslie Iversen, and Benjamin J. Whalley © Springer International Publishing Switzerland 2017 A.D. Kinghorn, H. Falk, S. Gibbons, J. Kobayashi (eds.), Phytocannabinoids, Progress in the Chemistry of Organic Natural Products 103, 61-100. DOI 10.1007/978-3-319-45541-9_3 Contents 1 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . [...]
Lire la suiteThe origins of cannabis smoking : Chemical residue evidence from the first millennium BCE in the Pamirs Meng Ren, Zihua Tang, Xinhua Wu, Robert Spengler, Hongen Jiang, Yimin Yang, Nicole Boivin Science Advances, 2019, 5 : eaaw1391 (12 June 2019) DOI: 10.1126/sciadv.aaw1391 Cannabis is one of the oldest cultivated plants in East Asia, grown for grain and fiber as well as for recreational, medical, and ritual purposes. It is one of the most widely used psychoactive drugs in the world today, but little is known about its early psychoactive use or when plants under cultivation evolved the phenotypical trait of increased specialized compound production. [...]
Lire la suitePhytochemical and genetic analyses of ancient cannabis from Central Asia Ethan B. Russo, Hong-En Jiang, Xiao Li, Alan Sutton, Andrea Carboni, Francesca del Bianco, Giuseppe Mandolino, David J. Potter, You-Xing Zhao, Subir Bera, Yong-Bing Zhang, En Guo Lu, David K. Ferguson, Francis Hueber, Liang-Cheng Zhao, Chang-Jiang Liu, Yu-Fei Wang and Cheng-Sen Li Journal of Experimental Botany, 2008, Vol. 59, No. 15, pp. 4171–4182, doi:10.1093/jxb/ern260 Abstract The Yanghai Tombs near Turpan, Xinjiang-Uighur Autonomous Region, China have recently been excavated to reveal the 2700-year-old grave of a Caucasoid shaman whose accoutrements included a large cache of cannabis, superbly preserved by climatic and burial conditions. A multidisciplinary international [...]
Lire la suiteA reliable and validated LC-MS/MS method for the simultaneous quantification of 4 cannabinoids in 40 consumer products Qingfang Meng, Beth Buchanan, Jonathan Zuccolo, Mathieu-Marc Poulin, Joseph Gabriele, David Charles Baranowski PLoS ONE, 2018, 13, 5, e0196396. https://doi.org/10.1371/journal.pone.0196396 Abstract In the past 50 years, Cannabis sativa (C. sativa) has gone from a substance essentially prohibited worldwide to one that is gaining acceptance both culturally and legally in many countries for medicinal and recreational use. As additional jurisdictions legalize Cannabis products and the variety and complexity of these products surpass the classical dried plant material, appropriate methods for measuring the biologically active constituents is paramount to ensure [...]
Lire la suiteCannabis sativa L. and Nonpsychoactive Cannabinoids : Their Chemistry and Role against Oxidative Stress, Inflammation, and Cancer Federica Pellati, Vittoria Borgonetti, Virginia Brighenti, Marco Biagi, Stefania Benvenuti, and Lorenzo Corsi Hindawi, BioMed Research International, 2018, Volume 2018, Article ID 1691428, 15 pages https://doi.org/10.1155/2018/1691428 Abstract In the last decades, a lot of attention has been paid to the compounds present in medicinal Cannabis sativa L., such as Δ9- tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD), and their effects on inflammation and cancer-related pain.The National Cancer Institute (NCI) currently recognizes medicinal C. sativa as an effective treatment for providing relief in a number of symptoms associatedwith cancer, including pain, [...]
Lire la suiteKetamine Promising in Cocaine Addiction Batya Swift Yasgur, MA, LSW American Journal of Psychiatry, July 05, 2019 https://doi.org/10.1176/appi.ajp.2019.18101123 A single ketamine infusion combined with mindfulness-based relapse prevention therapy (MBRP) improves abstinence and cuts cravings in cocaine-dependent adults, new research suggests. Results of a randomized control trial show that rates of abstinence were significiantly higher in patients who received ketamine plus MBRP compared to control patients. Moreover, those in the group that received ketamine were significantly less likely to experience relapse compared to control persons, and cravings were also significantly lower in the ketamine group throughout the trial. "In individuals receiving MBRP, a single ketamine infusion led to significantly greater [...]
Lire la suiteREBUS and the Anarchic Brain: Toward a Unified Model of the Brain Action of Psychedelics R. L. Carhart-Harris and K. J. Friston Pharmacological Reviews, 2019, 71, 316–344 https://doi.org/10.1124/pr.118.017160 Significance Statement . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 317 I. Introduction. . . . . . . . . . . . . . . . . . . . . . . . . [...]
Lire la suiteSpectral signatures of serotonergic psychedelics and glutamatergic dissociatives Carla Pallavicini, Martina G. Vilas, Mirta Villarreal, Federico Zamberlan, Suresh Muthukumaraswamy, David Nutt, Robin Carhart-Harris, Enzo Tagliazucchi NeuroImage, 2019 https://doi.org/10.1016/j.neuroimage.2019.06.053 Abstract Classic serotonergic psychedelics are remarkable for their capacity to induce reversible alterations in consciousness of the self and the surroundings, mediated by agonism at serotonin 5-HT2A receptors. The subjective effects elicited by dissociative drugs acting as N-methyl-D-aspartate (NMDA) antagonists (e.g. ketamine and phencyclidine) overlap in certain domains with those of serotonergic psychedelics, suggesting some potential similarities in the brain activity patterns induced by both classes of drugs, despite different pharmacological mechanisms of action. We investigated source-localized [...]
Lire la suiteCANNABIS PEER REVIEW 1964-2016 Over 650 Peer Reviewed Reports & Studies On Cannabis A Free Jeff Prager Publication Health benefits, cancer fighting qualities and many other medicinal advantages can be attributed to the Cannabis Plant. Likewise, diseases and disorders are also related to smoking, vaping and ingesting components of the Cannabis Plant. Cannabis users should be aware and well informed regarding both the positive effects and the negative consequences of regular Cannabis use and this eBook accomplishes that goal by employing over 400 current peer reviewed reports and studies—their findings— with active hyper links to each report. A Free Jeff Prager No-Copyright Publication for [...]
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