http://cannabis-med.org/data/pdf/en_2016_01_1.pdf Cannabinoids 2016; 11 (special issue), 1-18 © International Association for Cannabinoid Medicines Review Review on clinical studies with cannabis and cannabinoids 2010-2014 Mikael A. Kowal1, Arno Hazekamp1, Franjo Grotenhermen2 Bedrocan, Veendam, The Netherlands nova-Institut, Chemiepark Knapsack, Industriestraße, D-50354 Hürth, Germany Abstract In 2010 a review by Hazekamp and Grotenhermen covered controlled clinical trials of the years 2006-2009 on cannabis-based medicines, which followed the example of the review by Ben Amar (2006). The current review reports on the more recent clinical data available from 2010- 2014. A systematic search was performed in the scientific database of PubMed, focused on clinical studies that were randomized, (double) blinded, and placebo-controlled. The key words [...]
Lire la suiteSur l'excellent site de l'IACM (International Association for Cannabinoid Medicines), sur le lien suivant, vous trouverez tous les essais cliniques (Cannabis et cannabinoides) répertoriés par nos voisins allemands (merci au Dr Franjo Grotenhermen, fondateur de l'Association) http://www.cannabis-med.org/studies/study.php le lien suivant,répertorie ces essais cliniques, en français, par pathologies étudiées : http://www.cannabis-med.org/french/studies.htm
Lire la suitePréface à la traduction française de « Marijuana Medical Handbook, a Guide to Therapeutic Use » de Ed Rosenthal, Dale Gieringer et Tod Mikuriya, 1998, Editions du Lézard, Paris. Docteur Bertrand Lebeau C’est un plaisir pour moi de préfacer la traduction française de « Marijuana Medical Handbook, a Guide to Therapeutic Use » de Ed Rosenthal, Dale Gieringer et Tod Mikuriya. A ma connaissance, c’est, en français, le premier guide pratique pour l’utilisateur de cannabis à des fins thérapeutiques. Il vient après plusieurs ouvrages essentiels parmi lesquels « L’empereur est nu » de Jack Herer et « Cannabis, la médecine interdite » de Lester Grinspoon et James Bakalar [...]
Lire la suiteFrançais, encore un effort pour le cannabis thérapeutique ! Dr Bertrand Lebeau, texte pour Michka, mai 2008. La redécouverte des propriétés thérapeutiques du cannabis est récente dans les pays occidentaux mais, désormais, les recherches se multiplient et les cadres légaux se transforment. Pour comprendre la situation actuelle il faut faire un bref retour en arrière. Tout d’abord l’utilisation de « drogues » comme médicaments est habituelle et l’on peut affirmer que toute drogue a été, est ou sera un médicament. La morphine, et dans certains pays l’héroïne, sont utilisées pour leurs propriétés contre la douleur, la cocaïne a bouleversé la chirurgie de l’œil [...]
Lire la suiteLe cannabis médical en France Dr Bertrand Lebeau, 2014 La situation qui prévaut en France en matière de cannabis médical est profondément paradoxale. D’un côté, les pouvoirs publics font preuve d’une grande pusillanimité et l’on peut dire, sans esprit polémique, que notre pays se situe nettement en queue de peloton en Europe. Ainsi 17 pays européens nous ont précédé avant que la ministre française de la Santé, Marisol Touraine, demande en 2013 à l’instance en charge de ce type de dossier, l’Agence Nationale de Sécurité du Médicament (ANSM), d’examiner la possibilité d’une Autorisation de Mise sur le Marché (AMM) pour le Sativex [...]
Lire la suiteBibliographie CANNABINOIDES et Maladies Neurodégénératives Dr Christian Sueur, GRECC, avril 2019 (2e édition). ALTAMURA C. et al. : Elevation of Plasma 2 –Arachidonoylglycerol Levels in Alzheimer’s Disease Patients as a Potential Protective Mechanism against Neurodegenerativ Decline, Journal of Alzheimer Disease, 2015, 46, 2, 497-506. ASO E., SANCHEZ-PLA A., VEGAS-LOZANO, MALDONADO R., FERRER I. : Cannabis-based medicine reduces multiple pathological process in AβPP/PS1 mice, Journal of Alzheimer’s Disease, 2015, 43, 977-991. ASO E. et al. : Delineating the Efficacy of a Cannabis-Based Medicine at Advanced Stages of Dementia in a Murine Model, Journal of Alzheimer Disease, 2016, 54, 3, 903-912. BISOGNO T., ODDI S., PICCOLI [...]
Lire la suiteMedicinal cannabis - Potential Drug Interactions M.A. Alsherbiny, C. Guang Li, décembre 2018. www.preprints.org, doi:10.20944/preprints201812.0032.v1 https://www.researchgate.net/publication/329559938_Medicinal_Cannabis_-_Potential_Drug_Interactions Endocannabinoids system (ECS) engrossed a considerable interest as potential therapeutic targets in various carcinomas and cancer related conditions alongside with neurodegenerative diseases. Cannabinoids are implemented in several physiological processes such as appetite stimulation, energy balance, pain modulation and the control of chemotherapy induced nausea and vomiting (CINV). However, pharmacokinetics and pharmacodynamics interactions could be perceived in drug combinations, so in this short review we tried to shed the light over the potential drug interactions of medicinal cannabis. Hitherto, few data have been provided to the healthcare practitioners about [...]
Lire la suiteAntidépresseur-like effect induced by Cannabidiol is dependent on brain serotonin levels. A.J. Sales, C. C. Crestani, F. S. Guimaraes, S. R.L. Joca, Progress in Neuropsychopharmacology & Biological Psychiatry, 2018 Aug 30; 86: 255-261. Doi: 10.1016/j.pnpbp.2018.06.002 https://www.ncbi.nlm.nih.gov/pubmed/29885468 PMID : 29885468 Abstract Cannabidiol (CBD) is a compound of Cannabis sativa with relevant therapeutic potential in several neuropsychiatric disorders including depression. CBD treatment has shown significant antidepressant-like effects in different rodent preclinical models. However, the mechanisms involved in CBD-induced antidepressant effects are still poorly understood. Therefore, this work aimed at investigating the participation of serotonin (5-HT) and/or noradrenaline (NA) in CBD-induced antidepressant-like effects in [...]
Lire la suiteCannabis and the Anxiety of Fragmentation - A Systems Approach for Finding an Anxiolytic Cannabis Chemotype, B. S. Kamal, F. Kamal, D. E. Lantela, Frontiers in Neuroscience, 2018, 12, article 730. https://doi.org/10.3389/fnins.2018.00730 Abstract : Cannabis sativa is a medicinal herb with a diverse range of chemotypes that can exert both anxiolytic and anxiogenic effects on humans. Medical cannabis patients receiving organically grown cannabis from a single source were surveyed about the effectiveness of cannabis for treating anxiety. Patients rated cannabis as highly effective overall for treating anxiety with an average score of 8.03 on a Likert scale of 0 to 10 (0 = not effective, [...]
Lire la suiteThe Endocannabinoid System as A Target for Novel Anxiolytic and Antidepressant Drugs, Chapter 5 S. Gaetani, P. Dipasquale, A. Romano, L. Righetti, T. Cassano, D. Piomelli, V. Cuomo, International Review of Neurobiology, 2009, 85, 57-72 DOI: 10.1016/S0074-7742(09)85005-8 https://www.researchgate.net/publication/26675793_Chapter_5_The_Endocannabinoid_System_as_A_Target_for_Novel_Anxiolytic_and_Antidepressant_Drugs I. The Endogenous Cannabinoid System II. Endocannabinoid Role in Emotional Reactivity and Mood Tone III. EVects of Exogenously Administered Cannabinoid Agonists and Antagonists IV. Enhancement of the Endogenous Cannabinoid Tone V. Faah-Knockout Phenotype VI. Conclusions References Observational studies in humans suggest that exposure to marijuana and other cannabis-derived drugs produces a wide range of subjective eVects on mood tone and emotionality. These observations have their counterpart in animal studies, showing that cannabinoid agonists strongly [...]
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