Reefer Madness : A Case of Cannabis-Induced Psychosis Matthew C. Ballenberger, Robert D. Glatter, Daniel P. Klein, Steven Mandel, Medscape Psychiatry, August 15, 2019 Clinical Presentation A 32-year-old woman with a history of iron-deficiency anemia was brought in by ambulance because of altered mental status. The patient's sister and boyfriend reported that 1 day before presentation, the patient had ingested a marijuana edible and a few hours later developed fatigue and nausea, followed by at least 15 episodes of nonbloody, nonbilious, projectile vomiting throughout the night. In the morning, she became very pale, her lips turned blue, and she became stiff, losing consciousness for [...]
Lire la suiteOpioïdes : le cannabidiol pour réduire la dépendance ? Le cannabidiol (CBD) réduit le craving et l'anxiété chez les personnes ayant des antécédents d'abus d'héroïne/opioïdes, suggérant un rôle possible du cannabis ou de son agent le cannabidiol dans la réduction de la dépendance aux opioïdes. C’est la conclusion de cette étude réalisée à l’Icahn School of Medicine du Mont Sinaï (New York), présentée dans l'American Journal of Psychiatry. L'étude confirme également les effets anti-stress du CBD avec une baisse de la fréquence cardiaque et du taux de cortisol induites par les stimuli de drogues. La grande disponibilité des opioïdes sur prescription ces [...]
Lire la suiteAssociations between Adolescent Cannabis Use and Neuropsychological Decline : A Longitudinal Co-Twin Control Study Madeline H. Meier, Avshalom Caspi, Andrea Danese, Helen L. Fisher, Renate Houts, Louise Arseneault, & Terrie E. Moffitt Addiction. 2018, 113, (2), 257-265. doi: 10.1111/add.13946. Abstract Aims : This study tested whether adolescents who used cannabis or met criteria for cannabis dependence showed neuropsychological impairment prior to cannabis initiation and neuropsychological decline from before to after cannabis initiation. Design : A longitudinal co-twin control study. Setting and Participants : Participants were 1,989 twins from the Environmental Risk (E-Risk) Longitudinal Twin Study, a nationally representative birth cohort of twins born in England and Wales [...]
Lire la suiteAssociations between adolescent cannabis use frequency and adult brain structure : A prospective study of boys followed to adulthood. Madeline H. Meier, Roberta A. Schriber, Jordan Beardslee, Jamie Hanson, Dustin Pardini Drug and Alcohol Dependence, 2019, 202, 191-199 Copyright © 2019. Published by Elsevier B.V. PMID : 31357120 DOI : 10.1016/j.drugalcdep.2019.05.012 Abstract BACKGROUND : Few studies have tested the hypothesis that adolescent cannabis users show structural brain alterations in adulthood. The present study tested associations between prospectively-assessed trajectories of adolescent cannabis use and adult brain structure in a sample of boys followed to adulthood. METHODS : Data came from the Pittsburgh Youth Study - a longitudinal [...]
Lire la suiteConsommer du cannabis à l’adolescence n’aurait pas d’impact sur la structure du cerveau à l’âge adulte 31 juillet 2019 Floriane Ramfos © DR La dangerosité du cannabis pour le développement neuronal des adolescents est un argument courant chez les partisans de la prohibition. Pourtant, selon une étude du Drug and Alcohol Dependence, la consommation de cannabis pendant l’adolescence n’est pas associée à des différences structurelles dans le cerveau à l’âge adulte. Méthodologie et résultats L’étude a été réalisée auprès de 1000 hommes, auxquels les chercheurs ont demandé de déclarer leur consommation de cannabis lorsqu’ils avaient entre 13 à 19 ans. Cela a permis aux scientifiques d’identifier différentes [...]
Lire la suitePrevalence and Correlates of Cannabis Use in Outpatients with Serious Mental Illness Receiving Treatment for Alcohol Use Disorders Jordan Skalisky, Emily Leickly, Oladunni Oluwoye, Sterling M. McPherson, Debra Srebnik, John M. Roll, Richard K. Ries, and Michael G. McDonell Cannabis and Cannabinoid Research, 2017, 2, (1), 133-138 DOI: 10.1089/can.2017.0006 Abstract Introduction : People with serious mental illness (SMI) use cannabis more than any other illicit drug. Cannabis use is associated with increased psychotic symptoms and is highly comorbid with alcohol use disorders (AUDs). Despite the national trend toward decriminalization, little is known about the prevalence, correlates, and impact of cannabis use on those with SMI [...]
Lire la suiteHow Adolescents with Autism Spectrum Disorder (ASD) Spontaneously Attend to Real-World Scenes : Use of a Change Blindness Paradigm Michal Hochhauser, Adi Aran, Ouriel Grynszpan Journal of Autism and Developmental Disorders, 2018, 48, 502–510 DOI 10.1007/s10803-017-3343-6 https://www.researchgate.net/publication/320647151_How_Adolescents_with_Autism_Spectrum_Disorder_ASD_Spontaneously_Attend_to_Real-World_Scenes_Use_of_a_Change_Blindness_Paradigm [accessed Jul 16 2019]. Abstract Visual attention of adolescents with autism spectrum disorder (ASD) was assessed using a change blind-ness paradigm. Twenty-five adolescents with ASD aged 12–18 years and 25 matched typically developing (TD) adolescents viewed 36 pairs of digitized real-world images. Each pair of images was displayed in a ‘flicker paradigm’ whereby a particular item alternately appeared and disappeared. This item was either a central or a marginal [...]
Lire la suiteLe cannabidiol en traitement «anti-addictif» chez les patients alcooliques : l’étude CARAMEL PHRC-N 2018 n°0198 Investigateur principal B. Rolland François Bailly, service d’hépatologie et d’addictologie, Hôpital de la Croix Rousse, Lyon. Le cannabidiol en traitement « anti-addictif » chez les patients alcooliques : l’étude CARAMEL François Bailly Hôpital de la Croix-Rousse, Lyon Le protocole CARAMEL, qui devrait démarrer début 2020, est destiné à étudier l’intérêt du cannabidiol dans la dépendance alcoolique. Le projet d’étude est centré sur les effets du CBD sur le système nerveux central et les neuroprotecteurs et antioxydants, qui ont un impact sur la toxicité de l’alcool au niveau du cerveau et du foie, [...]
Lire la suitePrescribing Health Care Providers’ Attitudes, Experiences, and Practices Surrounding Cannabis Use in Patients with Anxiety Disorders and Post-Traumatic Stress Disorder Jake Rosenberg, Mallory J.E. Loflin, Yasmin L. Hurd, and Marcel O. Bonn-Miller Cannabis and Cannabinoid Research, 2019, Volume 4, Number 2, DOI: 10.1089/can.2018.0008 Abstract Background : Preliminary evidence suggests that certain cannabinoids may be beneficial for the treatment of anxiety and post-traumatic stress disorder (PTSD). However, it is unclear whether prescribing health care professionals view medicinal cannabis as a safe and effective option for treatment of these disorders. Methods : Three hundred fifty-two prescribing health care professionals across the United States completed an online survey assessing [...]
Lire la suiteHow effective and safe is medical cannabis as a treatment of mental disorder ? A systematic review HOCH E., NIEMANN D., von KELLER R., SCHNEIDER M., FRIEMEL C.M., PREUSS U.W., HASAN A., POGARELL O. European Archives of Psychiatry and Clinical Neuroscience, 2019 https://doi.org/10.1007/s00406-019-00984-4 Abstract We conducted a review of systematic reviews (SRs) and randomized-controlled trials (RCTs) to analyze efficacy and safety of cannabis-based medication in patients with mental disorders. Five data bases were systematically searched (2006—August 2018); 4 SRs (of 11 RCTs) and 14 RCTs (1629 participants) were included. Diagnoses were: dementia, cannabis and opioid dependence, psychoses/schizophrenia, general social anxiety, posttraumatic stress disorder, anorexia nervosa, [...]
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