Cannabinoid Regulation of Fear and Anxiety : an Update Eleni P. Papagianni & Carl W. Stevenson Current Psychiatry Reports, 2019, 21, 38 doi : 10.1007/s11920-019-1026-z Abstract Purpose of Review : Anxiety- and trauma-related disorders are prevalent and debilitating mental illnesses associated with a significant socioeconomic burden. Current treatment approaches often have inadequate therapeutic responses, leading to symptom relapse. Here we review recent preclinical and clinical findings on the potential of cannabinoids as novel therapeutics for regulating fear and anxiety. Recent Findings : Evidence from preclinical studies has shown that the non-psychotropic phyto-cannabinoid cannabidiol and the endocannabinoid anandamide have acute anxiolytic effects and also regulate learned fear [...]
Lire la suiteIACM-Bulletin du 13 Janvier 2020 Italie: Selon la Haute Cour, cultiver de petites quantités de cannabis à la maison n'est pas un crime Science/Homme: L'apport oral de graisse peut augmenter de deux fois la biodisponibilité systémique du THC Science/Homme: L'exercice a réduit le nombre de maux de tête et les niveaux d'anandamide chez les personnes souffrant de migraine Science/Homme: Selon une enquête les patients atteints du syndrome de la Tourette préfèrent le cannabis médical au THC pur et au Sativex En bref Un coup d'œil sur le passé Italie: Selon la [...]
Lire la suitePatient-reported use of medical cannabis for pain, anxiety, and depression symptoms : Systematic review and meta-analysis Jesse D. Kosiba, Stephen A. Maisto, Joseph W. Ditre Social Science & Medicine, 2019, 181-192. https://doi.org/10.1016/j.socscimed.2019.06.005 This study is the first to conduct a systematic review and meta-analysis of empirical studies that assess patient-reported reasons for using medical cannabis to alleviate pain, anxiety, and depression. The present review further assessed the quality of studies and identified several methodological flaws in extant research. Highlights •Systematically reviewed studies why patients use medical cannabis. •Pain was a common reason for medical cannabis use (64%). •Anxiety (50%) and depression (34%) were [...]
Lire la suiteThe Role of Cannabis in Treating Anxiety : An Update Michael Van Ameringen; Jasmine Zhang; Beth Patterson; Jasmine Turna Current Opinion in Psychiatry, 2019, 33, (1), 1-7. DOI : 10.1097/YCO.0000000000000566 https://www.medscape.com/viewarticle/922111?nlid=133169_425&src=WNL_mdplsfeat_191224_mscpedit_psyc&uac=292598PZ&spon=12&impID=2219742&faf=1 Abstract and Introduction Abstract Purpose of review: Cannabis use for medical purposes has become increasingly common, including as treatment for mental health disorders such as anxiety. Unfortunately, the evidence examining its use in mental health has been slow to evolve, but is emerging. Given the widespread use of cannabis, it is important for both clinicians and those who suffer with anxiety to understand the effects of cannabis on symptoms of anxiety. In this review, we present [...]
Lire la suiteON THE PREPARATIONS OF THE INDIAN HEMP, OR GUNJAH, (Cannabis Indisa) Their Effects on the Animal System in Health, and their Utility in the Treatment of Tetanus and other Convulsive Diseases. By W. B. O'SHAUGHNESSY, M.D., Bengal Army, Late Professor of Chemistry and Materia Medica in the Medical College of Calcutta. PROVINCIAL MEDICAL JOURNAL and Retrospect of the Medical Science No. 123. London, Saturday, February 4, 1843. [Concluded from p. 347.] experiments by the Author-Inferences as to the Acton of the Drug on Animals and Man.
Lire la suiteEffects of CBD-Enriched Cannabis sativa Extract on Autism Spectrum Disorder Symptoms : An Observational Study of 18 Participants Undergoing Compassionate Use Paulo Fleury-Teixeira, Fabio Viegas Caixeta, Leandro Cruz Ramires da Silva, Joaquim Pereira Brasil-Neto and Renato Malcher-Lopes Frontiers in Neurology, October 2019, Volume 10, Article 1145 doi : 10.3389/fneur.2019.01145 Autism Spectrum Disorders comprise conditions that may affect cognitive development, motor skills, social interaction, communication, and behavior. This set of functional deficits often results in lack of independence for the diagnosed individuals, and severe distress for patients, families, and caregivers. There is a mounting body of evidence indicating the effectiveness of pure cannabidiol (CBD) and [...]
Lire la suiteTherapeutic Effects of Prolonged Cannabidiol Treatment on Psychological Symptoms and Cognitive Function in Regular Cannabis Users : A Pragmatic Open-Label Clinical Trial Nadia Solowij, Samantha J. Broyd, Camilla Beale, Julie-Anne Prick, Lisa-marie Greenwood, Hendrika van Hell, Chao Suo, Peter Galettis, Nagesh Pai, Shanlin Fu, Rodney J. Croft, Jennifer H. Martin, and Murat Yücel Cannabis and Cannabinoid Research, 2018, 3, 1,21-35 Doi : 10.1089/can.2017.0043 Abstract Introduction : Chronic cannabis use has been associated with impaired cognition and elevated psychological symptoms, particularly psychotic-like experiences. While D9-tetrahydrocannabinol (THC) is thought to be primarily responsible for these deleterious effects, cannabidiol (CBD) is purported to have antipsychotic properties and to [...]
Lire la suiteProlonged Cannabidiol Treatment Effects on Hippocampal Subfield Volumes in Current Cannabis Users Camilla Beale, Samantha J. Broyd, Yann Chye, Chao Suo, Mark Schira, Peter Galettis, Jennifer H. Martin, Murat Yücel and Nadia Solowij Cannabis and Cannabinoid Research, 2018, 3, 1, 94-107. Doi : 10.1089/can.2017.0047 Abstract Introduction : Chronic cannabis use is associated with neuroanatomical alterations in the hippocampus. While adverse impacts of cannabis use are generally attributed to D9 tetrahydro-cannabinol, emerging naturalistic evidence suggests cannabidiol (CBD) is neuroprotective and may ameliorate brain harms associated with cannabis use, including protection from hippocampal volume loss. This study examined whether prolonged administration of CBD to regular cannabis users [...]
Lire la suiteIACM-Bulletin du 06 Décembre 2019 Science/Homme: Le cannabis riche en CBD pourrait être utile dans l'autisme Science/Homme: Le cannabis peut être utile dans le traitement de l'endométriose Science/Homme: Un extrait de chanvre riche en CBD peut réduire l'utilisation d'opiacés chez les patients souffrant de douleur chronique États-Unis: Un Comité de la Chambre des Représentants adopte un projet de loi historique visant à décriminaliser le cannabis Royaume-Uni: 20 000 patients bénéficieront d'un essai de cannabis médical En bref Un coup d'œil sur le passé Science/Homme: Le cannabis riche en CBD pourrait être [...]
Lire la suiteCannabidiol Counteracts the Psychotropic Side-Effects of Δ-9-Tetrahydrocannabinol in the Ventral Hippocampus Through Bi-Directional Control of ERK1-2 Phosphorylation Roger Hudson, Justine Renard, Christopher Norris, Walter J. Rushlow and Steven R. Laviolette The Journal of Neuroscience, 2019 https://doi.org/10.1523/JNEUROSCI.0708-19.2019 Abstract Evidence suggests that the phytocannabinoids Δ-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) differentially regulate salience attribution and psychiatric risk. The ventral hippocampus (vHipp) relays emotional salience via control of dopamine (DA) neuronal activity states, which are dysregulated in psychosis and schizophrenia. Using in-vivo electrophysiology in male Sprague Dawley rats, we demonstrate that intra-vHipp THC strongly increases ventral tegmental area (VTA) DA neuronal frequency and bursting rates, decreases GABA frequency, and [...]
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