Marijuana for Symptoms of PTSD in U.S. Veterans Category: MAPS-Sponsored Medical Marijuana Research https://maps.org/research/mmj/marijuana-us/ Placebo-Controlled, Triple-Blind, Randomized Crossover Pilot Study of the Safety and Efficacy of Four Different Potencies of Smoked Marijuana in 76 Veterans with Chronic, Treatment-Resistant Posttraumatic Stress Disorder (PTSD) Site Principal Investigator: Sue Sisley, M.D. Coordinating Principal Investigator: Marcel Bonn-Miller, Ph.D. Co-Investigator: Paula Riggs, M.D. This study has completed enrollment. This study will explore whether smoked marijuana can help reduce PTSD symptoms in 76 U.S. veterans with chronic, treatment-resistant posttraumatic stress disorder (PTSD). Participants must be U.S. veterans, men or women, aged 18 or older with a diagnosis of PTSD that has not improved after [...]
Lire la suiteEffects of cannabidiol on brain excitation and inhibition systems; a randomised placebo-controlled single dose trial during magnetic resonance spectroscopy in adults with and without autism spectrum disorder Charlotte Marie Pretzsch, Jan Freyberg, Bogdan Voinescu, David Lythgoe, Jamie Horder, Maria Andreina Mendez, Robert Wichers, Laura Ajram, Glynis Ivin, Martin Heasman, Richard A. E. Edden, Steven Williams, Declan G. M. Murphy, Eileen Daly and Gráinne M. McAlonan Neuropsychopharmacology, 2019, 0, 1–8; https://doi.org/10.1038/s41386-019-0333-8 Abstract : There is increasing interest in the use of cannabis and its major non-intoxicating component cannabidiol (CBD) as a treatment for mental health and neurodevelopmental disorders, such as autism spectrum disorder (ASD). However, before [...]
Lire la suiteTherapeutic effects of cannabinoids in animal models of seizures, epilepsy, epileptogenesis, and epilepsy-related neuroprotection. Evan C. Rosenberg, Pabitra H. Patra, and Benjamin J. Whalley Epilepsy & Behavior, 2017 May ; 70(Pt B), 319–327 PMID : 28190698 PMCID : PMC5651410 DOI : 10.1016/j.yebeh.2016.11.006 Abstract : The isolation and identification of the discrete plant cannabinoids in marijuana revived interest in analyzing historical therapeutic claims made for cannabis in clinical case studies and anecdotes. In particular, sources as old as the 11th and 15th centuries claimed efficacy for crude marijuana extracts in the treatment of convulsive disorders, prompting a particularly active area of preclinical research into [...]
Lire la suiteEtudes cliniques et précliniques Applications cliniques pour l’usage du cannabis et des cannabinoïdes en médecine Cette page est une traduction de la septième édition (2016) du « Clinical Applications for Cannabis and Cannabinoids » un document original de NORML USA édité à destination des médecins américains par Paul Armentano. Une actualisation en a été faite en 2017, mise à jour en français par nos soins en 2018. Alzheimer Sclérose Latérale Amyotrophique Douleur chronique Diabète sucré Dystonie Épilepsie Fibromyalgie Troubles gasto-intestinaux Gliomes / Cancers Hépatite C VIH – Virus de l’Immunodéficience Humaine Maladie de Huntington Hypertension Incontinence Migraine Staphylocoque doré méthycillino-résistant Sclérose en Plaques – SEP Ostéoporose [...]
Lire la suiteThe current state and future perspectives of cannabinoids in cancer biology Paweł Śledziński, Joanna Zeyland, Ryszard Słomski & Agnieszka Nowak Cancer Medicine, 2018 © 2018 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. doi: 10.1002/cam4.1312 Abstract : To date, cannabinoids have been allowed in the palliative medicine due to their analgesic and antiemetic effects, but increasing number of preclinical studies indicates their anticancer properties. Cannabinoids exhibit their action by a modulation of the signaling pathways crucial in the control of cell proliferation and survival. Many in vitro and in vivo experiments have shown that cannabinoids inhibit proliferation of cancer cells, stimulate autophagy and [...]
Lire la suiteTranslational Investigation of the Therapeutic Potential of Cannabidiol (CBD) : Toward a New Age José A. Crippa, Francisco S. Guimaraes, Alline C. Campos, Antonio W. Zuardi Frontiers in Immunology, 21 september 2018. https://doi.org/10.3389/fimmu.2018.02009 Background: Among the many cannabinoids in the cannabis plant, cannabidiol (CBD) is a compound that does not produce the typical subjective effects of marijuana. Objectives: The aim of the present review is to describe the main advances in the development of the experimental and clinical use of cannabidiol CBD in neuropsychiatry. Methods: A non-systematic search was performed for studies dealing with therapeutic applications of CBD, especially performed by Brazilian researchers. Results: CBD was shown [...]
Lire la suiteAutism Spectrum Disorder and Cannabidiol : Have We Seen This Movie Before? Carlos A. Salgado, and Daniel Castellanos, Glob Pediatr Health. 2018; 5: 2333794X18815412 doi: 10.1177/2333794X18815412 Received July 5, 2018. Received revised October 9, 2018. Accepted for publication October 23, 2018. Recently, the use of marijuana and cannabidiol (CBD) in children with autism spectrum disorder (ASD) has received increasing attention in the media with articles sensationally titled “Marijuana may be a miracle treatment for children with autism.” An absence of empirical data appears to have resulted in a growing body of anecdotal evidence espousing the benefits of CBD for children with ASD. Some reports describe the [...]
Lire la suiteCannabinoids for Behavioral Problems in Children With ASD (CBA) ClinicalTrials.gov Identifier : NCT02956226 Recruitment Status : Completed First Posted : November 7, 2016 Last Update Posted : December 27, 2018 https://clinicaltrials.gov/ct2/show/NCT02956226?term=cannabidiol&cond=Autism+Spectrum+Disorder Sponsor : Shaare Zedek Medical Center Information provided by (Responsible Party) : Dr. Adi Aran, Shaare Zedek Medical Center Study Description Brief Summary : This study aims to assess the safety, tolerability and efficacy of cannabinoids mix [cannabidiol (CBD), Δ9-tetrahydrocannabinol (THC) in a 20:1 ratio, BOL Pharma, Israel] for behavioral problems in children and youth with ASD. Condition or disease Intervention/treatment Phase Autistic Disorder Drug: Cannabinoids - 99% pure cannabinoids mixDrug: PlaceboDrug: Cannabinoids - whole plant extract Study Design Study [...]
Lire la suiteCannabidivarin (CBDV) vs. Placebo in Children With Autism Spectrum Disorder (ASD) ClinicalTrials.gov Identifier : NCT03202303 Recruitment Status : Not yet recruiting First Posted : June 28, 2017 Last Update Posted : April 2, 2019 https://clinicaltrials.gov/ct2/show/NCT03202303?term=cannabinoids&cond=Autism+Spectrum+Disorder&rank=2 Sponsor : Eric Hollander Collaborators : United States Department of Defense, GW Pharmaceuticals Information provided by (Responsible Party) : Eric Hollander, Montefiore Medical Center, USA Study Design Study Type : Interventional (Clinical Trial) Estimated Enrollment : 100 participants Allocation: Randomized Intervention Model: Parallel Assignment Intervention Model Description: Phase 2, 12-week double-blind, randomized, placebo-controlled trial Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor) Masking Description: Double-Blind Primary Purpose: Treatment Official Title: Cannabidivarin (CBDV) vs. Placebo in Children With Autism Spectrum Disorder (ASD) Estimated Study Start Date : June 2019 Estimated [...]
Lire la suiteA protocol for the delivery of cannabidiol (CBD) and combined CBD and ∆9-tetrahydrocannabinol (THC) by vaporisation Nadia SOLOWIJ, Samantha J. BROYD, Hendrika H. Van HELL, Arno HAZEKAMP BMC Pharmacol Toxicol, 2014, 15, 58 Published online 2014 Oct 16. doi: 10.1186/2050-6511-15-58 PMCID: PMC4274767 PMID: 25319497 Abstract Background Significant interest has emerged in the therapeutic and interactive effects of different cannabinoids. Cannabidiol (CBD) has been shown to have anxiolytic and antipsychotic effects with high doses administered orally. We report a series of studies conducted to determine the vaporisation efficiency of high doses of CBD, alone and in combination with ∆9-tetrahydrocannabinol (THC), to achieve faster onset effects in experimental and clinical [...]
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