Neuroimaging Studies of Acute Effects of THC and CBD in Humans and Animals : a Systematic Review A. Batalla, J.A. Crippa, G.F. Busatto, F.S. Guimarães, A.W. Zuardi, O. Valverde, Z. Atakan, P.K. McGuire, S. Bhattacharyya and R. Martín-Santos Current Pharmaceutical Design, 2014, 20, 2168-2185 DOI : 10.2174/13816128113199990432 Available from: https://www.researchgate.net/publication/247154314_Neuroimaging_Studies_of_Acute_Effects_of_THC_and_CBD_in_Humans_and_Animals_a_Systematic_Review [accessed May 19, 2019]. Abstract : Background : In recent years, growing concerns about the effects of cannabis use on mental health have renewed interest in cannabis research. In particular, there has been a marked increase in the number of neuroimaging studies of the effects of cannabinoids. We conducted a systematic review to assess the [...]
Lire la suiteCharacterization of Endocannabinoid-Metabolizing Enzymes in Human Peripheral Blood Mononuclear Cells under Inflammatory Conditions Brittany N. Szafran, Jung Hwa Lee, Abdolsamad Borazjani, Peter Morrison, Grace Zimmerman, Kelly L. Andrzejewski, Matthew K. Ross and Barbara L.F. Kaplan Molecules, 2018, 23, 3167 DOI : 10.3390/molecules23123167 Abstract: Endocannabinoid-metabolizing enzymes are downregulated in response to lipopolysaccharide (LPS) induced inflammation in mice, which may serve as a negative feedback mechanism to increase endocannabinoid levels and reduce inflammation. Increased plasma levels of the pro-inflammatory cytokine interleukin-6 (IL-6) and decreased fatty acid amide hydrolase (FAAH) activity in peripheral lymphocytes from individuals diagnosed with Huntington’s disease (HD) suggests that a similar negative feedback system [...]
Lire la suiteA Review of 3,4-methylenedioxymethamphetamine (MDMA)-Assisted Psychotherapy Ben Sessa, Laurie Higbed and David Nutt Frontiers in Psychiatry, 2019, Vol. 10, article 138 DOI : 10.3389/fpsyt.2019.00138 Neuropsychopharmacology Unit, Department of Medicine, Imperial College London, London, United Kingdom Abstract : This paper provides a brief review of the history, proposed pharmacological mechanisms, safety issues, and clinical applications of the medicine 3,4-methylenedioxymethamphetamine (MDMA). Most clinical MDMA research in patients to date has focused on MDMA-assisted psychotherapy to treat posttraumatic stress disorder (PTSD). In this review paper other potential therapeutic applications for MDMA therapy are described, including contemporary studies treating anxiety associated with autism and the authors’ ongoing study exploring the potential [...]
Lire la suite“To learn healing knowledge”: Philosophy, psychedelic studies and transformation David A. Pittaway South African Journal of Philosophy, 2018, 37, 4, 438-451 DOI : 10.1080/02580136.2018.1532186 Abstract : “Philosophical learning” may be summarised in Sobiecki’s fitting catchphrase “to learn healing knowledge”. This catchphrase is taken from an article on the use of psychoactive plants among southern African diviners. In the spirit of this link, I aim to challenge contemporary negative attitudes to the topic of psychedelics, and argue that there are good reasons for philosophers to pay attention to the role that the psychedelic experience can play in promoting philosophical perception. I argue first that the results [...]
Lire la suiteInvestigational Cannabinoids in Seizure Disorders, what have we learned thus far ? Dejana Ružić Zečević, Ziyad Tantoush, Marko Folić, Goran Babić, Milan Radovanović and Slobodan M. Janković may 2018, 23 pages ABSTRACT Introduction : Anticonvulsant activity of cannabinoid attracted much attention in the last decade. Cannabinoids that are currently investigated with intention to become drugs for treatment of epilepsy are cannabidiol, cannabidivarin, Δ9-tetrahydrocannabivarin and Δ9-tetrahydrocannabinolic acid. Areas covered : Topic of this review are results of pre-clinical and clinical studies with investigational cannabinoids. Relevant literature was searched for in MEDLINE, SCOPUS, EBSCO, GOOGLE SCHOLAR and SCINDEX databases. Expert opinion : Pre-clinical studies confirmed anticonvulsant activity of [...]
Lire la suitePRÉ-PROGRAMME : USAGES CLINIQUES des CANNABINOÏDES 24es PROFESSIONNELLES RENCONTRES DU RESPADD RÉSEAU DES ÉTABLISSEMENTS DE SANTÉ POUR LA PRÉVENTION DES ADDICTIONS En collaboration avec le GRECC (Groupe de Recherche et d’Etudes Cliniques sur les Cannabinoïdes) 20 et 21 JUIN 2019 PARIS ESPACE DU CENTENAIRE Quai de la Rapée 75012 Paris 9h30 – Accueil 10h00-12h30> Session Groupe de Recherche et d’Etudes Cliniques sur les Cannabinoïdes Président de séance : Christian Sueur, président du GRECC 10h00 – 10h30> Ouverture Ville de Paris, (sous réserve) ARS Ile-de-France, (sous réserve) Christian Sueur, président du GRECC 10h30 – 12h30 ÉTAT DES LIEUX DES ESSAIS CLINIQUES SUR LES CANNABINOÏDES EN FRANCE Discutant : Rodolphe Ingold, GRECC > Utilisation du Marinol en France : enquête [...]
Lire la suite#INSIGHT 2019 - Integrating science and practice of psychedelic states: International Conference (Sept 5th-7th, Berlin) INSIGHT 2019 - International Conference in Berlin: New Website online The INSIGHT 2019 conference website launched! Get your tickets now. Great international line-up (more to come). Tracks: Basic research, Therapy, Public Health, Philosophy at the Langenbeck-Virchow House Berlin-Mitte. https://insight-conference.eu #INSIGHT2019 #MINDacademy #Berlin Research about the psychedelic state and its applications in medical and other contexts has entered a new phase. Dozens of international Universities are involved in basic, clinical and public health research about classical psychedelics, novel substances and the contexts that facilitate positive, sustainable or negative outcomes. The [...]
Lire la suiteCannabinoïde Signaling in the Skin : Therapeutic Potential of the “C(ut)annabinoid” System Kinga Fanni Tóth, Dorottya Ádám, Tamás Bíró, and Attila Oláh Molecules 2019, 24(5), 918; https://doi.org/10.3390/molecules24050918 Abstract : The endocannabinoid system (ECS) has lately been proven to be an important, multifaceted homeostatic regulator, which influences a wide-variety of physiological processes all over the body. Its members, the endocannabinoids (eCBs; e.g., anandamide), the eCB-responsive receptors (e.g., CB1, CB2), as well as the complex enzyme and transporter apparatus involved in the metabolism of the ligands were shown to be expressed in several tissues, including the skin. Although the best studied functions over the ECS are [...]
Lire la suiteStreets of the ‘spice zombies’: Dependence and poverty stigma in times of austerity Liviu Alexandrescu School of History, Philosophy and Culture, Oxford Brookes University Crime Media Culture, 2019 Abstract Following the 2016 general ban on new psychoactive substances, synthetic cannabinoids (‘spice’-type drugs) have moved into unregulated street markets and have become popular among homeless populations in the United Kingdom. Images of so-called ‘spice zombies’, rough sleepers in public spaces experiencing severe substance-induced fits, have been used by local and national media to suggest the growing scale of the problem. This article proposes that such depictions should be read through a cultural analysis rooted in the [...]
Lire la suiteAssociation of Cannabis Use in Adolescence and Risk of Depression, Anxiety, and Suicidality in Young Adulthood - A Systematic Review and Meta-analysis Gabriella Gobbi, Tobias Atkin, Tomasz Zytynski, Shouao Wang, Sorayya Askari, Jill Boruff, Mark Ware, Naomi Marmorstein, Andrea Cipriani, Nandini Dendukuri, Nancy Mayo JAMA Psychiatry, 2019, 76, 4, 426-434. doi:10.1001/jamapsychiatry.2018.4500 Published online February 13, 2019. Corrected on March 13, 2019. https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2723657?guestAccessKey=c2ffca43-46c1-4563-8949-c1625bfbdefa&utm_source=silverchair&utm_medium=email&utm_campaign=article_alert-jamanetwork&utm_content=weekly_highlights&utm_term=051919 IMPORTANCE : Cannabis is the most commonly used drug of abuse by adolescents in the world. While the impact of adolescent cannabis use on the development of psychosis has been investigated in depth, little is known about the impact of cannabis use on mood [...]
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