Étiquette : terpènes

Cannabinoids, Phenolics, Terpenes and Alkaloids of Cannabis, Mohamed M. Radwan et al., 2021

Cannabinoids, Phenolics, Terpenes and Alkaloids of Cannabis Mohamed M. Radwan, Suman Chandra, Shahbaz Gul and Mahmoud A. ElSohly Molecules, 2021, 26, 2774. Doi : 10.3390/molecules26092774   Abstract : Cannabis sativa is one of the oldest medicinal plants in the world. It was introduced into western medicine during the early 19th century. It contains a complex mixture of secondary metabolites, including cannabinoids and non-cannabinoid-type constituents. More than 500 compounds have been reported from C. sativa, of which 125 cannabinoids have been isolated and/or identified as cannabinoids. Cannabinoids are C21 terpeno phenolic compounds specific to Cannabis. The non-cannabinoid constituents include: non-cannabinoid phenols, flavonoids, terpenes, alkaloids and others. This review discusses [...]

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Absence of Entourage : Terpenoids Commonly Found in Cannabis sativa Do Not Modulate the Functional Activity of Δ9-THC at Human CB1 and CB2 Receptors, Marina Santiago et al., 2019

Absence of Entourage : Terpenoids Commonly Found in Cannabis sativa Do Not Modulate the Functional Activity of Δ9-THC at Human CB1 and CB2 Receptors Marina Santiago, Shivani C. Arnold, Iain S., McGregor and Mark Connor Cannabis and Cannabinoid Research, 2019, Vol. 4, No. 3 doi : 10.1089/can.2019.0016 Abstract Introduction: Compounds present in Cannabis sativa such as phytocannabinoids and terpenoids may act in concert to elicit therapeutic effects. Cannabinoids such as Δ9-tetrahydrocannabinol (Δ9-THC) directly activate cannabinoid receptor 1 (CB1) and cannabinoid receptor 2 (CB2); however, it is not known if terpenoids present in Cannabis also affect cannabinoid receptor signaling. Therefore, we examined six common terpenoids alone, [...]

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Cannabis sativa L. as a Natural Drug Meeting the Criteria of a Multitarget Approach to Treatment, Anna Stasiłowicz et al., 2021

Cannabis sativa L. as a Natural Drug Meeting the Criteria of a Multitarget Approach to Treatment Anna Stasiłowicz, Anna Tomala, Irma Podolak and Judyta Cielecka-Piontek International Journal of Molecular Sciences, 2021, 22, 778. Doi : 10.3390/ijms22020778 Abstract : Cannabis sativa L. turned out to be a valuable source of chemical compounds of various structures, showing pharmacological activity. The most important groups of compounds include phytocannabinoids and terpenes. The pharmacological activity of Cannabis (in epilepsy, sclerosis multiplex (SM), vomiting and nausea, pain, appetite loss, inflammatory bowel diseases (IBDs), Parkinson’s disease, Tourette’s syndrome, schizophrenia, glaucoma, and coronavirus disease 2019 (COVID-19)), which has been proven so far, results [...]

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Cannabis : From Cultivar to Chemovar II—A Metabolomics. Approach to Cannabis Classification, Arno Hazekamp et al, 2016,

Cannabis : From Cultivar to Chemovar II—A Metabolomics. Approach to Cannabis Classification Arno Hazekamp, Katerina Tejkalova, and Stelios Papadimitriou Cannabis and Cannabinoid Research, 2016, Volume 1, (1) Doi : 10.1089/can.2016.0017 Abstract Introduction : There is a large disparity between the ‘‘cultural’’ language used by patients using cannabis for selfmedication and the ‘‘chemical’’ language applied by scientists to get a deeper understanding of cannabis effects in laboratory and clinical studies. The distinction between Sativa and Indica types of cannabis, and the different biological effects associated with them, is a major example of this. Despite the widespread use of cannabis by selfmedicating patients, scientific studies are yet [...]

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L’Italie classe les fleurs de chanvre parmi les plantes médicinales, Aurélien BERNARD, NEWSWEED.fr, 8 octobre 2020

L’Italie classe les fleurs de chanvre parmi les plantes médicinales Aurélien BERNARD NEWSWEED.fr, 8 octobre 2020 https://www.newsweed.fr/italie-classe-fleurs-chanvre-plantes-medicinales/   Un arrêté du Ministère italien des Politiques agricoles, alimentaires et forestières publié en août a classé la fleur de chanvre à usage extractif (« canapa infiorescenza a uso estrattivo« ) parmi les plantes médicinales. Quelles conséquences pour le marché italien du chanvre ? Selon Giacomo Bulleri, avocat au conseil d’administration de l’association italienne de chanvre Federcanapa, les conséquences pour le secteur chanvrier italien sont importantes. D’une part, l’inclusion de la fleur de chanvre sur la liste des plantes médicinales suggère que la plante est sur le point d’être reconnue comme un produit agricole. D’autre [...]

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Comment les terpènes affectent les effets d’une variété de cannabis ?, Aurélien Bernard, Newsweed.fr, 12 mai 2010

Comment les terpènes affectent les effets d’une variété de cannabis ? Publié le 12 mai 2020 NEWSWEED.fr , Par Aurélien BERNARD https://www.newsweed.fr/comment-terpenes-affectent-effets-variete-cannabis/     Lorsqu’on entend le mot terpène, la première idée qui vient à l’esprit est l’odeur d’une plante. La recherche scientifique a pourtant montré que les terpènes remplissent plus qu’une unique fonction sensorielle. Les terpènes produisent ainsi des effets spécifiques sur le corps, qu’ils soient anti-inflammatoires, antibactériens, relaxants ou anxiolytiques. C’est d’ailleurs aussi pour cette raison que certaines variétés procurent un sentiment de calme et de bien-être, alors que d’autres favorisent l’énergie. Les terpènes s’insèrent ainsi complètement dans l’effet d’entourage, qui suppose que les composants [...]

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Effet d’entourage contre douleur neuropathique, PrincipesActifs.org, 22 Mai 2020

Effet d’entourage contre douleur neuropathique Publié le 22 Mai 2020 https://www.principesactifs.org/effet-dentourage-contre-douleur-neuropathique/     Cette huile de cannabidiol est efficace contre la douleur neuropathique chronique, conclut cette étude pré-clinique de l’University of New Mexico (UNM). L’étude présentée dans la revue Life suggère que l’huile permet de diviser par 10 la sensibilité à la douleur mécanique et pendant plusieurs heures. Ici chez la souris modèle de douleur neuropathique postopératoire chronique. Ces données présentées dans la revue Life illustrent ce que les experts nomment l’effet d’entourage ou l’action synergique de différents composés du cannabis qui apporte cet effet thérapeutique. Dans cette expérience, il s’agit d’une huile de cannabis contenant [...]

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Terpenoids From Cannabis Do Not Mediate an Entourage Effect by Acting at Cannabinoid Receptors, David B. Finlay et al., 2020

Terpenoids From Cannabis Do Not Mediate an Entourage Effect by Acting at Cannabinoid Receptors David B. Finlay, Kathleen J. Sircombe, Mhairi Nimick, Callum Jones and Michelle Glass Frontiers in Pharmacology, 2020, Volume 11, Article 359, 1-9. doi : 10.3389/fphar.2020.00359   The entourage effect was a proposed explanation for biological observations that endocannabinoid ligand activities can be modified by other lipids released from cells at the same time. An increasing volume of anecdotal reports and interest in the plant have provoked research into the activity of minor chemical constituents of the plant—including volatile terpenoids such as myrcene, a- and b- pinene, b-caryophyllene, and limonene. However, to [...]

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A cross-sectional examination of choice and behavior of veterans with access to free medicinal cannabis, Mallory J. E. Loflin et al., 2019

A cross-sectional examination of choice and behavior of veterans with access to free medicinal cannabis Mallory J E Loflin, Kimberly Babson, James Sottile, Sonya B Norman, Staci Gruber, and Marcel O Bonn-Miller The American Journal of Drug and Alcohol Abuse, 2019, VOL. 45, NO. 5, 506–513. Doi : 10.1080/00952990.2019.1604722   ABSTRACT Background : With a rise in public pressure to increase veteran access to medicinal cannabis, free cannabis collectives for military veterans are proliferating across the US. Objectives : The aim of the current study was to document which cannabis formulations and routes of administration are chosen by veterans with increased access to cannabis, and to determine [...]

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Comprehensive classification of USA cannabis samples based on chemical profiles of major cannabinoids and terpenoids, Ramia Z. Al Bakain et al., 2019

Comprehensive classification of USA cannabis samples based on chemical profiles of major cannabinoids and terpenoids Ramia Z. Al Bakain, Yahya S. Al-Degs, James V. Cizdziel and Mahmoud A. Elsohly Journal of Liquid Chromatography & Related Technologies, 2019 Doi : 10.1080/10826076.2019.1701015   ABSTRACT Different USA-origin cannabis samples were analyzed by GC-FID to quantify all possible cannabinoids and terpenoids prior to their clustering. Chromatographic analysis confirmed the presence of seven cannabinoids and sixteen terpenoids with variable levels. Among tested cannabinoids, D9-Tetrahydro-cannabinol D9-THC and cannabinol CBN were available in excess amounts (1.2–8.0 wt%) and (0.22–1.1 wt%), respectively. Fenchol was the most abundant terpenoid with a range of (0.03–1.0 wt%). [...]

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