Cannabinoids and the endocannabinoid system in reward processing and addiction: from mechanisms to interventions Rainer Spanagel, PhD Dialogues in Clinical Neuroscience, 2020, 22, (3), 241-250. doi : 10.31887/DCNS.2020.22.3/rspanagel The last decades have seen a major gain in understanding the action of cannabinoids and the endocannabinoid system in reward processing and the development of addictive behavior. Cannabis-derived psychoactive compounds such as Δ9-tetrahydrocannabinol and synthetic cannabinoids directly interact with the reward system and thereby have addictive properties. Cannabinoids induce their reinforcing properties by an increase in tonic dopamine levels through a cannabinoid type 1 (CB1) receptor–dependent mechanism within the ventral tegmental area. Cues that are conditioned [...]
Lire la suiteCB2 Receptor Involvement in the Treatment of Substance Use Disorders Francisco Navarrete, María S. García-Gutiérrez, Ani Gasparyan, Daniela Navarro and Jorge Manzanares Biomolecules, 2021, 11, 1556, 1-18. Doi : 10.3390/biom11111556 Abstract The pharmacological modulation of the cannabinoid receptor 2 (CB2r) has emerged as a promising potential therapeutic option in addiction. The purpose of this review was to determine the functional involvement of CB2r in the effects produced by drugs of abuse at the central nervous system (CNS) level by assessing evidence from preclinical and clinical studies. In rodents, several reports suggest the functional involvement of CB2r in the effects produced by drugs of abuse such [...]
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