Serotonergic psychedelics and personality: a systematic review of contemporary research José Carlos Bouso, Rafael G. dos Santos, Miguel Ángel Alcázar-Córcoles, Jaime E. C. Hallak Neuroscience and Biobehavioral Reviews, 2018 PII: S0149-7634(17)30301-9 DOI: https://doi.org/10.1016/j.neubiorev.2018.02.004 Highlights Serotonergic psychedelics act as agonists at cortical 5-HT2A receptors 5-HT2A receptors are expressed in fronto-temporo-parieto-occipital areas Some personality traits seem to be related to 5-HT2A receptor expression Acute and long-term use of psychedelics is associated with personality changes Personality changes induced by psychedelics may have therapeutic effects Abstract Serotonergic psychedelics act as agonists at cortical 5-HT2A receptors and seem to induce personality changes. We conducted a systematic review of studies assessing the effects [...]
Lire la suitePsychological variables implied in the therapeutic effect of ayahuasca : a contextual approach. Alba Franquesa, Alberto Sainz-Cort, Sam Gandy, Joaquim Soler, Miguel Ángel Alcázar-Córcoles, José Carlos Bouso Psychiatry Research, 2017 PII: S0165-1781(17)31377-X DOI: 10.1016/j.psychres.2018.04.012 Abstract Ayahuasca is a psychedelic decoction originating from Amazonia. The ayahuasca-induced introspective experience has been shown to have potential benefits in the treatment of several pathologies, to protect mental health and to improve neuropsychological functions and creativity, and boost mindfulness. The underlying psychological processes related to the use of ayahuasca in a psychotherapeutic context are not yet well described in the scientific literature, but there is some evidence to suggest that psychological [...]
Lire la suiteLong-term effects of ayahuasca in patients with recurrent depression : a 5-year qualitative follow-up Rafael G. dos Santos, Rafael Faria Sanches, Flávia de Lima Osório, Jaime E.C. Hallak Archive of Clinical Psychiatry, 2018, 45, 1, 22-4 DOI: 10.1590/0101-60830000000149 Abstract Background : Ayahuasca is a botanical hallucinogenic preparation traditionally used by indigenous populations of Northwestern Amazonian countries for ritual and therapeutic purposes. It is rich in β-carboline alkaloids and N,N-dimethyltryptamine (DMT). Preclinical, observational, and experimental studies suggest that ayahuasca and its alkaloids have anxiolytic and antidepressive effects. We recently reported in an open-label trial that ayahuasca administration was associated with significant decreases in depression symptoms for [...]
Lire la suiteN, N-Dimethyltryptamine (DMT), an Endogenous Hallucinogen : Past, Present, and Future Research to Determine Its Role and Function Steven A. Barker Frontiers in Neuroscience, 2018, 12, 536. doi: 10.3389/fnins.2018.00536 This report provides a historical overview of research concerning the endogenous hallucinogen N, N-dimethyltryptamine (DMT), focusing on data regarding its biosynthesis and metabolism in the brain and peripheral tissues, methods and results for DMT detection in body fluids and brain, new sites of action for DMT, and new data regarding its possible physiological and therapeutic roles. Research that further elaborates its consideration as a putative neurotransmitter is also addressed. Taking these studies together, the report [...]
Lire la suiteAssessing the psychedelic “after-glow” in ayahuasca users: post-acute neurometabolic and functional connectivity changes are associated with enhanced mindfulness capacities. Ayahuasca post-acute effects Regular Research Article Frederic Sampedro, Mario de la Fuente Revenga, Marta Valle, Natalia Roberto, Elisabet Domínguez-Clavé, Matilde Elices, Luís Eduardo Luna, José Alexandre S. Crippa, Jaime E. C. Hallak, Draulio B. de Araujo, Pablo Friedlander, Steven A. Barker, Enrique Álvarez, Joaquim Soler, Juan C. Pascual, Amanda Feilding and Jordi Riba © The Author 2017. Published by Oxford University Press on behalf of CINP. The International Journal of Neuropsychopharmacology, 2017, 20, 9 DOI : 10.1093/ijnp/pyx036 Significance Statement Psychedelics are intriguing drugs that induce transient but intense [...]
Lire la suiteLysergic acid diethylamide (LSD) for alcoholism : meta-analysis of randomized controlled trials Teri S Krebs and Pål-Ørjan Johansen Journal of Psychopharmacology, 2012, 1–9 DOI: 10.1177/0269881112439253 jop.sagepub.com Abstract Assessments of lysergic acid diethylamide (LSD) in the treatment of alcoholism have not been based on quantitative meta-analysis. Hence, we performed a meta-analysis of randomized controlled trials in order to evaluate the clinical efficacy of LSD in the treatment of alcoholism. Two reviewers independently extracted the data, pooling the effects using odds ratios (ORs) by a generic inverse variance, random effects model. We identified six eligible trials, including 536 participants. There was evidence for a beneficial effect of LSD [...]
Lire la suitePsychedelic therapy in the Czech Republic : A theoretical concept or a realistic goal ? Zuzana Postranecka, Čestmir Vejmola and Filip Tyls Journal of Psychedelic Studies DOI: 10.1556/2054.2019.003 Abstract Psychedelic research has been associated with the Czech Republic since the early 19th century and, after a long period of involuntary dormancy, it has recently gained new opportunities to follow up on its roots and evolve. This article briefly describes the history of psychedelic research in the Czech Republic, summarizes the role of the UN Drug Conventions, and discusses the Czech and international legislation pertaining to psychedelics. The discussion focuses on the dependence/abuse potential of classical [...]
Lire la suiteRapid antidepressant effects of the psychedelic ayahuasca in treatment-resistant depression : a randomized placebo-controlled trial Fernanda Palhano-Fontes, Dayanna Barreto, Heloisa Onias, Katia C. Andrade, Morgana M. Novaes, Jessica A. Pessoa, Sergio A. Mota-Rolim, Flávia L. Osório, Rafael Sanches, Rafael G. dos Santos, Luís Fernando Tófoli, Gabriela de Oliveira Silveira, Mauricio Yonamine7, Jordi Riba, Francisco R. Santos, Antonio A. Silva-Junior, João C. Alchieri10, Nicole L. Galvão-Coelho5,11, Bruno Lobão-Soares5,12, Jaime E. C. Hallak, Emerson Arcoverde, João P. Maia-de-Oliveira and Dráulio B. Araújo Psychological Medicine, June 2018, 1-9 https://www.cambridge.org/core doi.org/10.1017/S0033291718001356 Abstract Background. Recent open-label trials show that psychedelics, such as ayahuasca, hold promise as fast-onset antidepressants in treatment-resistant depression. Methods. [...]
Lire la suiteDans la Silicon Valley, le retour des drogues psychédéliques Cinquante ans après le Summer of love, les ingénieurs et programmeurs de la Silicon Valley ont renoué avec les drogues psychédéliques, censées accroître la créativité et la performance. Les employeurs ferment les yeux, voire les encouragent. Par Elsa CONESA Publié le 04/04 à 06h00 https://www.lesechos.fr/tech-medias/hightech/dans-la-silicon-valley-le-retour-des-drogues-psychedeliques-1006461 Tous les matins, c'est le même rituel. « Je me lève, je bois un thé vert, je prends ma dose, puis je médite un peu. Sous la douche, déjà, je commence à sentir les bénéfices, j'ai plein d'idées qui apparaissent. » Lové dans un fauteuil de l'hôtel Rosewood Sand Hill, le QG officieux [...]
Lire la suiteDark Classics in chemical Neuroscience : Lysergic Acid Diethylamide (LSD), David E. Nichols, ACS Chemical Neuroscience, 2018, 9, 10, 2331-2334. doi: 10.1021/acschemneuro.8b00043. Abstract : LSD is one of the most potent psychoactive agents known, producing dramatic alterations of consciousness after submilligram (≥20 g) oral doses. Following the accidental discovery of its potent psychoactive effects in 1943, it was supplied by Sandoz Laboratories as an experimental drug that might be useful as an adjunct for psychotherapy, or to give psychiatrists insight into the mental processes in their patients. The finding of serotonin in the mammalian brain in 1953, and its structural resemblance to LSD, quickly led [...]
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