Étiquette : opioid crisis

Emerging Evidence for Cannabis’ Role in Opioid Use Disorder, Nicolas J. Schlienz et al., 2018

Emerging Evidence for Cannabis’ Role in Opioid Use Disorder Beth Wiese and Adrianne R. Wilson-Poe Cannabis and Cannabinoid Research, 2018, Volume 3.1, 179-189. Doi : 10.1089/can.2018.0022   Abstract Introduction : The opioid epidemic has become an immense problem in North America, and despite decades of research on the most effective means to treat opioid use disorder (OUD), overdose deaths are at an all-time high, and relapse remains pervasive. Discussion : Although there are a number of FDA-approved opioid replacement therapies and maintenance medications to help ease the severity of opioid withdrawal symptoms and aid in relapse prevention, these medications are not risk free nor are they successful [...]

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Prescription Opioid Distribution after the Legalization of Recreational Marijuana in Colorado, Amalie K. Kropp Lopez et al., 2020

Prescription Opioid Distribution after the Legalization of Recreational Marijuana in Colorado Amalie K. Kropp Lopez, Stephanie D. Nichols, Daniel Y. Chung, Daniel E. Kaufman, Kenneth L. McCall  and Brian J. Piper International Journal of Environmental Research and Public Health, 2020, 17, 3251 doi : 10.3390/ijerph17093251   Abstract : There have been dynamic changes in prescription opioid use in the US but the state level policy factors contributing to these are incompletely understood. We examined the association between the legalization of recreational marijuana and prescription opioid distribution in Colorado. Utah and Maryland, two states that had not legalized recreational marijuana, were selected for comparison. Prescription data reported to [...]

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Rationale for cannabis-based interventions in the opioid overdose crisis, Philippe Lucas, 2017

Rationale for cannabis-based interventions in the opioid overdose crisis Philippe Lucas Harm Reduction Journal, 2017, 14, 58 Doi : 10.1186/s12954-017-0183-9   Abstract Background : North America is currently in the grips of a crisis rooted in the use of licit and illicit opioid-based analgesics. Drug overdose is the leading cause of accidental death in Canada and the US, and the growing toll of opioid-related morbidity and mortality requires a diversity of novel therapeutic and harm reduction-based interventions. Research suggests that increasing adult access to both medical and recreational cannabis has significant positive impacts on public health and safety as a result of substitution effect. Observational and [...]

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What does the ecological and epidemiological evidence indicate about the potential for cannabinoids to reduce opioid use and harms ? A comprehensive review, Gabrielle Campbell, 2018

What does the ecological and epidemiological evidence indicate about the potential for cannabinoids to reduce opioid use and harms ? A comprehensive review Gabrielle Campbell, Wayne Hall and Suzanne Nielsen International Review of Psychiatry, 2018, 1-16. Doi : 10.1080/09540261.2018.1509842   ABSTRACT Pre-clinical research supports that cannabinoids reduce opioid dose requirements, but few studies have tested this in humans. This review evaluates ecological and epidemiological studies that have been cited as evidence that medical cannabis use may reduce opioid use and opioidrelated harms. Medline and Embase were searched for relevant articles. Data were extracted on study setting, analyses approach, covariates, and outcomes. Eleven ecological and 14 epidemiological [...]

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Cannabis Use Motivations among Adults Prescribed Opioids for Pain versus Opioid Addiction, Selena N. Clem et al., 2019

Cannabis Use Motivations among Adults Prescribed Opioids for Pain versus Opioid Addiction Selena N. Clem, Teresa L. Bigand, Marian Wilson Pain Management Nursing, 2019, 1-5. Doi : 10.1016/j.pmn.2019.06.009   a b s t r a c t Background : Cannabis has been linked to reduced opioid use, although reasons for cannabis use among adults prescribed opioids are unclear. Aims : The purpose of this study was to determine whether motivations for cannabis use differ between adults prescribed opioids for persistent pain versus those receiving opioids as medication-assisted treatment for opioid use disorder. Design : A cross-sectional survey design was used. Participants : Adults prescribed opioids for persistent pain (n [...]

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Opioid mortality following implementation of medical marijuana programs (1999-2017) in the United States, Daniel E. Kaufman et al., 2019

Opioid mortality following implementation of medical marijuana programs (1999-2017) in the United States Daniel E. Kaufman, Asawer M. Nihal, Janan D. Leppo, Kelly M. Staples, Kenneth L. McCall, Brian J. Piper BioRxiv preprint, June 14, 2019. Doi : 10.1101/670059   Abstract The United States is in the midst of an opioid overdose epidemic. A prior report using the Center for Disease Control’s Wide-ranging Online Data for Epidemiologic Research (WONDER) database discovered that opioid overdoses decreased by 24.8% from 1999 to 2010 in states with medical cannabis (MC+) relative to those without (MC-). The present study evaluated any differences following MC legislation on WONDER reported opioid overdoses, [...]

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Cannabis Use and Cognition in Adults Prescribed Opioids for Persistent Pain, Megan Wildes et al., 2019

Cannabis Use and Cognition in Adults Prescribed Opioids for Persistent Pain Megan Wildes, Teresa L. Bigand, Matthew E. Layton, , Marian Wilson Pain Management Nursing, 2019, 1-6. Doi : 10.1016/j.pmn.2019.06.014   a b s t r a c t Background : Adults with persistent pain frequently report cannabis use to help manage their symptoms. The impact of cannabis use on cognition in the presence of concurrent symptoms of depression and anxiety is poorly understood. Aims : Our study explored how cannabis use affects relationships among symptoms of depression, anxiety, and cognition. Design : A cross-sectional survey study was conducted. Settings : Surveys were distributed at outpatient clinics treating adults [...]

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Impact of co-administration of oxycodone and smoked cannabis on analgesia and abuse liability, Ziva D. Cooper et al., 2018

Impact of co-administration of oxycodone and smoked cannabis on analgesia and abuse liability Ziva D. Cooper, Gillinder Bedi, Divya Ramesh, Rebecca Balter, Sandra D. Comer and Margaret Haney Neuropsychopharmacology, 2018, 0, 1–10 Doi : 10.1038/s41386-018-0011-2   Cannabinoids combined with opioids produce synergistic antinociceptive effects, decreasing the lowest effective antinociceptive opioid dose (i.e., opioid-sparing effects) in laboratory animals. Although pain patients report greater analgesia when cannabis is used with opioids, no placebo-controlled studies have assessed the direct effects of opioids combined with cannabis in humans or the impact of the combination on abuse liability. This double-blind, placebo-controlled, within-subject study determined if cannabis enhances the analgesic effects [...]

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Medical cannibus as an alternative for opioids for chronic pain : A case report, Franklin E. Caldera, 2020

Medical cannibus as an alternative for opioids for chronic pain : A case report Franklin E. Caldera SAGE Open Medical Case Reports, 2020, Volume 8, 1–3 DOI : 10.1177/2050313X20907015   Abstract Opioid medication–related deaths have increased to epidemic proportions in the last decade. This report describes a case of 43-year-old female with a traumatic brain injury who developed chronic pain and opioid dependence. The patient expressed concerns and wanted weaning off opioids. Recent legalization of medical marijuana in Pennsylvania allows us to try it as an alternative to opioids for chronic pain. Medical cannibus has risks associated with administration but is safer than opioids. Our patient [...]

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Mapping cannabis potency in medical and recreational programs in the United States, Mary Catherine Cash et al., 2020

Mapping cannabis potency in medical and recreational programs in the United States Mary Catherine Cash, Katharine Cunnane, Chuyin Fan, E. Alfonso Romero-Sandoval PLoS ONE, 2020, 15, (3), e0230167. Doi : 10.1371/journal.pone.0230167     Opinion d'expert: Les allégations sur l'infaisabilité du cannabis avec des concentrations élevées de THC à des fins médicales ne sont pas étayées par la science En mars 2020, le conseil d'administration de l'IACM a décidé d'installer une nouvelle catégorie dans le Bulletin de l’IACM, qui encourage à rédiger des opinions et des déclarations de chercheurs sur les rapports scientifiques actuels et des déclarations de collègues. Ces avis visent à stimuler la discussion sur [...]

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