Effects of Cannabidiol and a Novel Cannabidiol Analog against Tactile Allodynia in a Murine Model of Cisplatin-Induced Neuropathy: Enhanced Effects of Sub-Analgesic Doses of Morphine Hannah Marie Harris, Waseem Gul, Mahmoud A. ElSohly, Kenneth J. Sufka Medical Cannabis and Cannabinoids, 2018, 1, 54–59 Preclinical Science and Clinical Studies – Research Article DOI: 10.1159/000489077 Abstract Objective : This research examined whether a cannabidiol (CBD)-opioid pharmacotherapy could attenuate cisplatin-induced tactile allodynia. Methods : Mice (C57BL/6) were given 6 doses of 2.3 mg/kg cisplatin intraperitoneally (IP) on alternating days to induce tactile allodynia as quantified using an electric von Frey (eVF). Test groups in Experiment 1 received either vehicle, 0.1 [...]
Lire la suiteL’amende forfaitaire pour usage de drogues doit être censurée par le Conseil constitutionnel Dix-neuf organisations demandent aux Sages de censurer l’article 58 de la loi de programmation 2018-2022 de réforme pour la justice qui est contraire à la Constitution. Cet article prévoit que le délit d’usage de stupéfiants peut désormais faire l’objet d’une amende forfaitaire de 200€. Monsieur le Président du Conseil constitutionnel, Mesdames et Messieurs les Membres du Conseil constitutionnel 2, rue Montpensier 75001 Paris. Paris, le 28 février 2019 Objet : Affaire n° 2019-778 DC Monsieur le Président du Conseil constitutionnel, Mesdames et Messieurs les membres du Conseil constitutionnel, Nous, organisations non-gouvernementales françaises, vous adressons ce jour notre [...]
Lire la suiteAmerican Story ! De la prohibition des opiacés (1914) à la crise des opioïdes (1995-2018) Dr Bertrand Lebeau Leibovici, CSAPA Valjean, Montfermeil (93), 2018. Du Harrison Act (1914) aux années 30 La grande vague de prohibition née dans les années 1880 dans le monde occidental aboutit aux premières conférences internationales (Shanghaï, 1909, et La Haye, 1912). Dans le même temps, les premières législations nationales apparaissent aux Etats-Unis (1914), en France (1916), en Grande-Bretagne (1920). Précédant de 5 ans la « loi sèche » (Volstead Act) de 1919 qui prohibera l’alcool durant 15 ans, le Harisson Act vise à interdire la production, l’importation et la [...]
Lire la suitePills to Pot : Observational Analyses of Cannabis Substitution Among Medical Cannabis Users With Chronic Pain Kevin F. Boehnke, J. Ryan Scott, Evangelos Litinas, Suzanne Sisley, David A. Williams, Daniel J. Clauw The Journal of Pain, 2019 https://www.jpain.org/article/S1526-5900(18)30735-1/fulltext DOI : https://doi.org/10.1016/j.jpain.2019.01.010 Highlights •Medical cannabis users reported substituting cannabis for pain medications. •User rationale for substitution was fewer side effects and better pain management. •Most users reported improved pain and health since using cannabis. •Intentions behind and duration of cannabis use affected substitution behavior. •Unlike previous studies, >50% of participants were women and adults >50 years old. Abstract Chronic pain is common, costly, and challenging to treat. Many [...]
Lire la suiteCannabis as a Substitute for Opioid-Based Pain Medication: Patient Self-Report Amanda REIMAN, Mark WELTY, Perry SOLOMON Cannabis and Cannabinoid Research, 2017, Vol 2, n°1 Abstract Introduction: Prescription drug overdoses are the leading cause of accidental death in the United States. Alternatives to opioids for the treatment of pain are necessary to address this issue. Cannabis can be an effective treatment for pain, greatly reduces the chance of dependence, and eliminates the risk of fatal overdose compared to opioid-based medications. Medical cannabis patients report that cannabis is just as effective, if not more, than opioid-based medications for pain. Materials and Methods: The current study examined the [...]
Lire la suiteThe neurobiology of addiction George R. Uhl, George F. Koob, and Jennifer Cable ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 2019 Special Issue: Addiction Reviews https://doi.org/10.1111/nyas.13989 Substance and alcohol use disorders impose large health and economic burdens on individuals, families, communities, and society. Neither prevention nor treatment efforts are effective in all individuals. Results are often modest. Advances in neuroscience and addiction research have helped to describe the neurobiological changes that occur when a person transitions from recreational substance use to a substance use disorder or addiction. Understanding both the drivers and consequences of substance use in vulnerable populations, including those whose brains are [...]
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