Neuroprotective Effect of Cannabidiol Against Hydrogen Peroxide in Hippocampal Neuron Culture Jungnam Kim, Ji Yu Choi, Jeongyeon Seo, and Insung S. Choi Cannabis and Cannabinoid Research, 2020,Volume X, Number X, Doi : 10.1089/can.2019.0102 Abstract Introduction: Reports on the neurotoxic and neuroprotective effects of cannabidiol (CBD) have not been in complete accord, showing different and somewhat contradictory results depending upon the brain cell types and experimental conditions employed. This work systematically examines the neuroprotective capability of CBD against oxidative stress (i.e., hydrogen peroxide [H2O2]) as well as its toxicity profile in the in vitro culture platform of primary hippocampal neurons. Materials and Methods: The low cell-density (100 neurons [...]
Lire la suiteBibliographie CANNABINOÏDES et Neuroprotection Docteur Christian Sueur, GRECC, février 2020.
Lire la suiteCannabidiol Reduces Brain Damage and Improves Functional Recovery After Acute Hypoxia-Ischemia in Newborn Pigs Hector LAFUENTE, Francisco J. ALVAREZ, M. Ruth PAZOS, Antonia ALVAREZ, M. Carmen REY-SANTANO, Victoria MIELGO, Xabier MURGIA-ESTEVE, Enrique HILARIO, and Jose MARTINEZ-ORGADO Pediatric Research, 2011, 70, 272–277. ABSTRACT : Newborn piglets exposed to acute hypoxia-ischemia (HI) received i.v. cannabidiol (HI CBD) or vehicle (HI VEH). In HI VEH, 72 h post-HI brain activity as assessed by amplitudeintegrated EEG (aEEG) had only recovered to 42 9% of baseline, near-infrared spectroscopy (NIRS) parameters remained lower than normal, and neurobehavioral performance was abnormal (27.8 2.3 points, normal 36). [...]
Lire la suiteCannabidiol protects an in vitro model of the blood–brain barrier from oxygen-glucose deprivation via PPARγ and 5-HT1A receptors William H Hind, Timothy J England and Saoirse E O’Sullivan British Journal of Pharmacology, 2016, 173, 815–825. Doi : 10.1111/bph.13368 BACKGROUND AND PURPOSE In vivo and in vitro studies have demonstrated a protective effect of cannabidiol (CBD) in reducing infarct size in stroke models and against epithelial barrier damage in numerous disease models. We aimed to investigate whether CBD also affects blood–brain barrier (BBB) permeability following ischaemia. EXPERIMENTAL APPROACH Human brain microvascular endothelial cell (HBMEC) and human astrocyte co-cultures modelled the BBB. Ischaemia was modelled by oxygen–glucose deprivation (OGD) [...]
Lire la suiteCannabis as Medicine: How CBD (Cannabidiol) Benefits the Brain and Nervous System Audrey Lefebvre wakeup-world.com/2016/03/20/cannabis-as-medicine-how-cbd-cannabidiol-benefits-the-human-brainand-nervous-system/ Cannabidiol (CBD) is an active cannabinoid found in cannabis which, unlike THC (tetrahydro-cannabinol), does not produce a psychoactive effect in the brain. For this reason, CBD has become a primary focus of medicinal cannabis studies. CBD has been found to have a wide range of benefits, including lowering blood sugar levels, promoting bone growth, and importantly, protecting the human brain and nervous system from degeneration. How CBD Protects the Nervous System The nervous system is comprised of two main parts: the peripheral nervous system, which includes the nerves and ganglia on [...]
Lire la suiteCannabis Exposure is Associated With a Lower Likelihood of Neurocognitive Impairment in People Living With HIV Caitlin Wei-Ming Watson, Emily W. Paolillo, Erin E. Morgan, Anya Umlauf, Erin E. Sundermann, Ronald J. Ellis, MD, Scott Letendre, Thomas D. Marcotte, Robert K. Heaton, and Igor Grant Journal of Acquired Immune Deficiency Syndromes, 2020, 83, (1), 56–64. Doi : 10.1097/QAI.0000000000002211 Background : Aging and HIV have adverse effects on the central nervous system, including increased inflammation and neural injury and confer risk of neurocognitive impairment (NCI). Previous research suggests the nonacute neurocognitive effects of cannabis in the general population are adverse or null. However, in the [...]
Lire la suiteLe cannabidiol, un agent thérapeutique prometteur ? Benjamin Rolland , Mathieu Chappuy, Patrizia Carrieri SWAPS, 3e et 4e trimestre 2019, n° 92-93, , 5-6. Deuxième cannabinoïde le plus étudié après le THC, sans effet psychoactif, le cannabidiol dispose de propriétés thérapeutiques intéressantes, notamment en psychiatrie. Le point sur les recherches La grande famille des cannabinoïdes Les cannabinoïdes sont un ensemble de substances capables d’activer les récepteurs du même nom (« récepteurs cannabinoïdes »). Il existe deux grandes familles de récepteurs cannabinoïdes, CB1 et CB2. Dans le système nerveux central, c’est surtout CB1 qui est exprimé, alors que CB2 est principalement présent dans le système immunitaire. [...]
Lire la suite6 variétés de cannabis pleines de THCV Aurélien BERNARD Newsweed.fr, 30 janvier 2020 https://www.newsweed.fr/5-varietes-cannabis-thcv/ À mesure que les connaissances scientifiques sur le cannabis se développent, la composition chimique du cannabis et la manière dont il interagit avec le corps se dévoilent. Et si le CBD ou le THC sont largement étudiés, certains cannabinoïdes plus rares comme le THCV (tetrahydocannabivarine) intéressent de plus en plus les scientifiques. Au cours de la dernière décennie, des études sur des humains et des animaux ont identifié le potentiel du THCV pour réduire l’appétit chez les personnes qui luttent pour perdre du poids, réguler la glycémie chez les personnes atteintes [...]
Lire la suiteThe cannabinoids : An overview. Therapeutic implications in vomiting and nausea after cancer chemotherapy, in appetite promotion, in multiple sclerosis and in neuroprotection R. Mechoulam PhD, L Hanus PhD Pain Research Management, 2001, 6, (2), 67-73. Doi : 10.1155/2001/183057 The present paper describes the historical use of cannabis, starting with its use in Assyria and China. Recent advances in the understanding of the molecular basis of cannabis action are explained, including the identification of the cannabinoid receptors CB1 and CB2, as well as the isolation of endogenous cannabinoids from the brain and periphery. The use of delta9-tetrahydrocannabinol as an antivomiting and antinausea drug for cancer [...]
Lire la suiteBIBLIOGRAPHIE : Beta-Carbolines Harmine, Harmane, Harmaline, Nor-harmane, Harmol, Harmalol, Tetrahydroharmine β-Carbolines et Thérapeutique en Psychiatrie, p. 6. (cf également Bibliographie : Peganum harmala, p. 7 ci-dessous, et Bibliographie : Amanita muscaria, et Bibliographie : Ayahuasca) Dr Christian SUEUR, GRECC, décembre 2019.
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